Abacavir Tablets

Description

Abacavir Tablets (300 mg / 600 mg)

Healthy Inc is a specialized global supplier and exporter of advanced anti-infectives, virology, and targeted immunology therapeutics. We provide ultra-high-purity, kinetically optimized Abacavir Tablets, manufactured in WHO–GMP certified, high-precision specialized antiviral facilities. This “Nucleoside Reverse Transcriptase Inhibitor (NRTI)” is a massive-volume strategic export to infectious disease hospitals, HIV/AIDS treatment centers, and government health ministries, serving as a globally mandated component for Highly Active Antiretroviral Therapy (HAART).

Product Overview

This formulation operates as a “Molecular Decoy.” It is a carbocyclic synthetic nucleoside analogue that tricks the HIV virus into using a faulty building block during its replication process.

• Mechanism 1 (Intracellular Activation): Once swallowed, Abacavir is converted inside the cell into its active form, Carbovir Triphosphate.

• Mechanism 2 (Reverse Transcriptase Inhibition): Carbovir Triphosphate competes with the natural building block (dGTP) for a spot in the viral DNA chain. The HIV enzyme Reverse Transcriptase mistakenly incorporates the drug into the DNA strand.

   

• Mechanism 3 (DNA Chain Termination): Because Abacavir lacks the necessary molecular “hook” to attach the next building block, the viral DNA synthesis physically stops (terminates). This prevents the virus from completing its genetic map and spreading to new cells.

   

Product Composition & Strength

We supply this product in standardized strengths to allow for both adult and pediatric weight-based dosing.

Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments containing other active substances – Antivirals)

   

• CAS Number: 136470-78-5 (Abacavir)

   

• Dosage Form: Film-Coated Tablet

   

• Packaging: High-Density Polyethylene (HDPE) Bottles or Alu-Alu Blisters. Our high-barrier packaging ensures 24-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Antiviral Purity Excellence: Our manufacturing process focuses on absolute chemical stability of the Sulfate salt, ensuring the NRTI remains potent and provides the predictable viral suppression required for chronic HIV management.

• Specialized Antiviral Production: We utilize Dedicated Non-Penicillin Blocks with advanced air filtration and primary containment to ensure zero cross-contamination, meeting the strictest international regulatory standards.

Primary Indications

• Infectious Disease: Treatment of HIV-1 infection in adults and pediatric patients.

   

• Combination Therapy: Must always be used in combination with other antiretroviral agents (e.g., Lamivudine, Dolutegravir).

   

Dosage & Administration

• Adults: 600 mg daily (either 300 mg twice daily or 600 mg once daily).

• Administration: Can be taken with or without food.

• Important: Dosage adjustment is required for patients with mild hepatic impairment.

Safety Warning: Hypersensitivity Reaction (HSR). Abacavir can cause serious and sometimes fatal allergic reactions. MANDATORY: All patients should be screened for the HLA-B*5701 allele before starting treatment. If a reaction occurs (fever, rash, GI symptoms, or fatigue), the drug must be stopped immediately and never restarted. Lactic Acidosis: Monitor for signs of lactic acidosis and severe hepatomegaly.

 

Global Export & Contract Manufacturing

Healthy Inc is a premier Antiviral Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume HIV therapeutics. Whether you are a Global Health Fund buyer in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.