Amlodipine Tablet

Amlodipine Tablets IP 5 mg

Each Uncoated tablet contains :

Amlodipine Besylate IP

Eq to Amlodipine 5 mg

Amlodipine Tablets IP 10 mg

Each Uncoated Tablet Contains :

Amlodipine Besylate IP

Eq To Amlodipine 10 mg

Amlodipine Besylate Tablets IP 2.5 mg

Each uncoated tablet contains :

Amlodipine Besylate IP

Eq. To Amlodipine 2.5 mg

Amlodipine Besylate Tablets IP 2.5 mg

Each Film Coated Tablet Contains:

Amlodipine Besylate IP

eq. To Amlodipine 2.5 mg

Amlodipine Besylate Tablets IP 5 mg

Each Film Coated Tablet Contains:

Amlodipine Besylate IP

eq. To Amlodipine 5 mg

AMLODIPINE & ENALAPRIL MALEATE TABLET

Each Film Coated Tablet Contains :

Amlodipine Besylate

Eq. To Amlodipine 5 mg

Enalapril Maleate 5 mg

Excipients q.s

AMLODIPINE & LISINOPRIL TABLET

Each Film Coated Tablet Contains :

Amlodipine Besylate

Eq. To Amlodipine 5 mg

Lisinopril dihydrate

Eq. To Lisinopril 5 mg

Excipients q.s

TRIPPLEACE AMLODIPINE -10 / AMLODIPINE

TABLETS 10 MG

Each uncoated tablet contains:

Amlodipine Besilate BP

Equivalent to Amlodipine 10 mg

Excipients Q.S.

Product Overview

• Vascular Selectivity: Unlike non-dihydropyridines (like Verapamil), Amlodipine has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. It relaxes the peripheral arteries, lowering peripheral vascular resistance and reducing blood pressure.
• Angina Relief:
  • Stable Angina: Reduces the "afterload" (resistance) the heart must pump against, lowering oxygen demand.
  • Prinzmetal's (Variant) Angina: Prevents spasms of the coronary arteries, restoring blood flow to the heart muscle.
• Once-Daily Dosing: With a unique long half-life (30–50 hours), it provides consistent 24-hour control with a single daily dose, avoiding the "peaks and valleys" seen with shorter-acting drugs.
• Metabolic Neutrality: Does not negatively impact lipid levels or glucose metabolism, making it safe for diabetic and dyslipidemic patients.

Product Composition & Strength

Technical & Logistics Specifications

Manufacturing Authority

• Photostability: Amlodipine is extremely sensitive to light (photolabile) and degrades into pyridine derivatives if exposed. We use opaque blisters (White PVC or Alu-Alu) to ensure the product remains stable until consumption.
• Dissolution: Our formulation ensures rapid disintegration and dissolution (>85% in 30 mins) to guarantee consistent bioavailability.

Therapeutic Indications (Human Use)

• Hypertension: Alone or in combination with other antihypertensive agents (Thiazides, ACE inhibitors, ARBs).
• Chronic Stable Angina: For symptomatic relief of chest pain.
• Vasospastic Angina (Prinzmetal's): Confirmed or suspected coronary artery spasm.
• Angiographically Documented CAD: To reduce the risk of hospitalization for angina and coronary revascularization procedures.

Dosage & Administration

• Route: Oral.
• Adults (Standard): Initiate with 5 mg once daily. Dosage may be increased to a maximum of 10 mg depending on patient response.
• Small, Fragile, or Elderly Patients: Initiate with 2.5 mg once daily.
• Hepatic Insufficiency: Amlodipine is extensively metabolized by the liver. Patients with liver failure should start at 2.5 mg.
• Timing: Can be taken without regard to meals.

• Peripheral Edema: Commonly causes swelling of the ankles/feet due to precapillary vasodilation. This is dose-dependent (more common at 10 mg).
• Hypotension: Symptomatic low blood pressure is rare but possible, especially in patients with severe aortic stenosis.
• Heart Failure: Use with caution in patients with heart failure.

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