Clotrimazole Vaginal Pessaries

Description

Clotrimazole Vaginal Pessaries (100 mg / 500 mg)

Healthy Inc is a specialized global supplier and exporter of advanced gynaecology, women’s health, and antifungal therapeutics. We provide ultra-high-purity, kinetically stable Clotrimazole Vaginal Pessaries, manufactured in WHO–GMP certified, high-precision facility. This “Broad-Spectrum Imidazole Antifungal” is a massive-volume strategic export to maternity hospitals, retail pharmacies, and international B2B distributors, serving as the globally preferred intervention for the treatment of vaginal yeast infections and fungal leucorrhoea.

Product Overview

This formulation operates as a “Direct Fungal Cytolytic.” It physically targets the integrity of the fungal cell wall to eliminate the infection at the source.

• Mechanism 1 (Ergosterol Synthesis Inhibition): Clotrimazole physically inhibits the enzyme lanosterol 14α-demethylase. This chemically blocks the synthesis of Ergosterol, the vital component of the fungal cell membrane.

• Mechanism 2 (Cellular Leakage): Without ergosterol, the fungal membrane becomes physically porous. This chemically leads to the leakage of essential intracellular phosphorus and potassium, physically causing Cell Death (Lysis).

• Mechanism 3 (Localized Bioavailability): A key physical advantage is its High Tissue Adhesion. It physically remains in the vaginal canal to provide sustained antifungal action while maintaining negligible absorption into the bloodstream.

Product Composition & Strength

We supply this product as Uncoated Vaginal Tablets (Pessaries), optimized for rapid disintegration in the moisture of the vaginal cavity.

Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments acting on the genito-urinary system / Others)

• CAS Number: 23593-75-1 (Clotrimazole)

• Dosage Form: Vaginal Pessary (Tablet)

• Packaging: 1 x 6 (100mg) or 1 x 1 (500mg) Blister Packs with a specialized Applicator. Our specialized packaging ensures 36-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Disintegration Precision: The effectiveness of a pessary depends physically on its ability to dissolve in low-moisture environments. Our manufacturing process utilizes Advanced Super-Disintegrants to ensure the tablet physically breaks down into a uniform antifungal film within minutes of insertion.

• Hormonal Containment: We utilize Dedicated Cleanroom Suites for fungal and gynaecological manufacturing to prevent cross-contamination and ensure the highest purity for sensitive patients.

• Anatomical Safety: We ensure the physical shape of the pessary is Bullet-Shaped/Ovoid with rounded edges, providing the most comfortable physical experience for the patient.

Primary Indications

• Gynaecology: Treatment of Vulvovaginal Candidiasis (Vaginal Thrush/Yeast Infection).

• Infectious Disease: Management of vaginal discharge (Leucorrhoea) caused by fungal pathogens.

• Secondary Prevention: Relief of vaginal itching, burning, and irritation associated with yeast overgrowth.

Dosage & Administration

• Standard Regimen (100mg): Typically one 100mg pessary inserted daily for 6 consecutive days (usually at night).

• Stat Regimen (500mg): Typically one 500mg pessary as a single dose for immediate high-potency treatment.

• Administration: It is physically critical to insert the pessary deep into the vagina using the provided applicator, preferably while lying on the back with knees slightly drawn up.

• Timing: It is physically best to apply the dose at bedtime to ensure the medication remains in contact with the mucosal tissue throughout the night.

Safety Warning: For Vaginal Use Only. Do Not Swallow. Pregnancy Note: In the first trimester, the pessary should physically be inserted by hand without using the applicator. Latex Note: This product may physically weaken latex condoms and diaphragms; use alternative contraception for 3 days after treatment. Contraindication: Do not use during menstruation or in patients with known hypersensitivity to Imidazoles.

Global Export & Contract Manufacturing

Healthy Inc is a premier Gynaecology and Women’s Health Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume Clotrimazole pessaries. Whether you are a National Women’s Health Program in the CIS or a B2B Pharma Marketplace partner in Africa or SE Asia, we ensure secure, WHO-GMP compliant delivery.