Cefixime and Clavulanic Acid Tablets

Description

Cefixime & Potassium Clavulanate Tablets (200 mg / 125 mg)

Healthy Inc is a specialized global supplier and exporter of advanced anti-infectives, pediatrics, and targeted beta-lactamase-resistant therapeutics. We provide ultra-high-purity, kinetically balanced Cefixime & Clavulanic Acid Tablets, manufactured in WHO–GMP certified, dedicated Beta-Lactam high-containment facilities. This “3rd-Generation Cephalosporin & Beta-Lactamase Inhibitor FDC” is a massive-volume, high-tier export to tertiary care hospitals, pediatric networks, and government health ministries, serving as the globally preferred intervention for Multi-Drug Resistant (MDR) Enteric Fever (Typhoid) and refractory Respiratory Tract Infections.

Product Overview

This formulation operates as a sophisticated, dual-front biochemical assault. It is specifically engineered to neutralize the “Shielding Enzymes” that bacteria use to survive modern antibiotics, thereby restoring the full bactericidal potency of the 3rd-generation cephalosporin.

• Mechanism 1 (The Disarming Agent – Clavulanic Acid): Potassium Clavulanate is a “Suicide Inhibitor” of beta-lactamase enzymes. It physically binds to the active site of the enzymes produced by resistant bacteria (like H. influenzae and E. coli), permanently deactivating them. This prevents the antibiotic from being destroyed before it reaches its target.

• Mechanism 2 (The Structural Executioner – Cefixime): With its “bodyguard” (Clavulanic Acid) neutralizing the defenses, Cefixime is free to bind to Penicillin-Binding Proteins (PBPs). This halts the synthesis of the bacterial cell wall, leading to rapid osmotic lysis and bacterial death.

• Mechanism 3 (The Enteric Advantage): Cefixime achieves very high concentrations in the bile and gallbladder. When combined with Clavulanic Acid, it becomes the ultimate oral weapon against Resistant Salmonella typhi, ensuring total eradication of the carrier state in Typhoid patients.

Product Composition & Strength

We supply this product as a Precision-Blended, Moisture-Protected Tablet, packed exclusively in high-barrier Alu-Alu blister strips to ensure the stability of the highly sensitive Clavulanate payload.

Technical & Logistics Specifications

• HS Code: 3004.20.00 (Medicaments containing antibiotics)

• CAS Numbers: 79350-37-1 (Cefixime) / 61177-45-5 (Potassium Clavulanate)

• Dosage Form: Film-Coated Tablet (Immediate Release)

• Packaging: Alu-Alu Blisters (STRICTLY MANDATORY). Potassium Clavulanate degrades rapidly in the presence of moisture. Alu-Alu is the only packaging that guarantees 24-month potency in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Dedicated Beta-Lactam Isolation: To eliminate cross-contamination risks, production is strictly confined to Dedicated Cephalosporin Suites with independent HVAC systems and HEPA filtration.

• API Stability Control: We utilize Micro-encapsulated Clavulanate to ensure maximum stability during the high-speed tableting process, providing global buyers with a product that maintains 100% efficacy until the date of expiration.

Dosage & Administration

• Standard Adult Dosing: 1 tablet taken twice daily (BID) for 7 to 14 days, depending on the severity of the infection.

• The “Full Stomach” Recommendation: While Cefixime absorption is high, taking this FDC after a meal minimizes the gastrointestinal side effects (diarrhea/nausea) often associated with Clavulanate.

Safety Warning: Strictly contraindicated in patients with a history of cholestatic jaundice or hepatic dysfunction associated with cephalosporins. 10% cross-reactivity risk in penicillin-allergic patients. Adjust dose for patients with renal impairment ($CrCl < 20$ mL/min).

Global Export & Contract Manufacturing

Healthy Inc is a premier Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-end Resistance-Breaking FDCs. Whether you are a Government Tender Supplier for typhoid programs in Africa or a B2B Pharma Marketplace partner in Latin America, we ensure secure, WHO-GMP compliant delivery.