Description

Thiocolchicoside Capsules

Healthy Inc is a specialized global supplier and exporter of advanced orthopedic, rheumatological, and musculoskeletal therapeutics. We provide high-purity Thiocolchicoside Capsules (4 mg / 8 mg), manufactured in WHO–GMP certified oral solid dosage facilities. This “Semi-Synthetic Centrally Acting Muscle Relaxant” is a high-volume, mandatory export to orthopedic hospitals, sports medicine clinics, trauma centers, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a highly targeted intervention for acute, painful muscle contractures and spinal spasms.

Product Overview

This formulation contains Thiocolchicoside, a semi-synthetic sulfurated derivative of colchicoside, a naturally occurring compound extracted from the seeds of the Gloriosa superba (flame lily) plant.

The “Non-Sedating Spasmolytic” Specialist:

• Mechanism (Dual Receptor Modulation): Thiocolchicoside acts purely in the central nervous system. It exhibits a highly specific affinity for both GABA-A receptors and strychnine-sensitive Glycine receptors in the spinal cord and brain. By modulating these inhibitory pathways, it drastically reduces the hyper-excitability of motor neurons, physically releasing acute muscle contractures.
• The Alertness Advantage: The greatest clinical limitation of traditional muscle relaxants (like Methocarbamol or Diazepam) is profound, debilitating daytime sedation. Thiocolchicoside delivers powerful myorelaxant effects without significantly depressing the central nervous system, allowing patients to maintain full alertness, drive safely, and engage in physical therapy during recovery.
• Anti-Inflammatory Synergy: Beyond its primary spasmolytic action, it also possesses mild anti-inflammatory and analgesic properties, making it an ideal standalone therapy or adjunct to NSAIDs for severe acute back pain.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in moisture-resistant Alu-Alu or Alu-PVC blister strips.

*Pack Sizes: 10×10 Alu-Alu Blisters. (Highly recommended to preserve the integrity of the natural derivative).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Orthopedic Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Botanical Extraction & Purification: Because the precursor is extracted from Gloriosa superba seeds, our manufacturing process utilizes advanced High-Performance Liquid Chromatography (HPLC) to guarantee absolute elimination of toxic colchicine alkaloids. The final semi-synthetic API boasts 99.5% purity, ensuring unparalleled clinical safety.
• Rapid Gastric Dispersion: The formulation is engineered with premium disintegrants, ensuring the capsule shell ruptures within 5 minutes of ingestion. This rapid dissolution provides peak plasma concentrations within 1 to 2 hours, essential for fast relief in emergency room or acute trauma settings.

Therapeutic Indications (Human Use)

Indicated for the short-term management of severe, painful musculoskeletal disorders:

• Acute Lumbar Pain (Lumbago): Relief of severe lower back spasms associated with herniated discs or acute muscular strain.
• Acute Torticollis: Rapid relief of severe neck stiffness and contractures.
• Post-Traumatic Spasms: Adjunct therapy for sports injuries, sprains, and post-surgical orthopedic recovery.

Dosage & Administration

Recommended Dosage (Strictly as per Orthopedist / EMA Guidelines):

• Administration: Taken orally, usually every 12 hours, preferably with meals to minimize gastrointestinal discomfort.
• Maximum Daily Dose: The maximum recommended dose is 8 mg every 12 hours (16 mg per day).
• Strict Duration Limit (CRITICAL): Treatment duration MUST NOT exceed 7 consecutive days for the oral capsule formulation.

Safety Warnings (CRITICAL):

• Aneuploidy & Genotoxicity Risk: Long-term use of Thiocolchicoside results in the accumulation of a metabolite (M3) that can cause aneuploidy (an abnormal number of chromosomes in dividing cells). This genotoxic risk can harm male fertility and cause severe fetal damage. Therefore, the 7-day maximum duration limit is strictly enforced globally.
• Absolute Contraindication in Pregnancy: It is strictly contraindicated in women who are pregnant, breastfeeding, or of childbearing potential not using highly effective contraception.
• Seizure Threshold: Thiocolchicoside can occasionally lower the seizure threshold. It must be used with extreme caution in patients with a history of epilepsy or those taking concurrent medications that lower the seizure threshold.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Orthopedic Formulations, allowing brands to launch high-quality generic medicines under their contract label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.