Description

Piroxicam Injection

Healthy Inc is a specialized global supplier and exporter of highly effective analgesic and anti-inflammatory therapies. We provide high-purity Piroxicam Injection (20 mg / ml), manufactured in WHO–GMP certified sterile facilities. This “Oxicam-Class NSAID” is a mandatory export to orthopedic centers, rheumatology clinics, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a powerful, once-daily intervention for the acute relief of severe musculoskeletal pain and debilitating arthritic flare-ups.

Product Overview

This formulation contains Piroxicam, a highly potent, non-steroidal anti-inflammatory drug (NSAID) belonging to the enolic acid (oxicam) group.

The “Extended Duration” Pain Specialist:

• Mechanism (Prostaglandin Blockade): Piroxicam reversibly binds to and non-selectively inhibits both Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) enzymes. This profound inhibition blocks the conversion of arachidonic acid to pro-inflammatory prostaglandins and thromboxanes, severely blunting the inflammatory cascade at the tissue level.
• The 50-Hour Half-Life: Unlike shorter-acting NSAIDs (like Diclofenac or Ibuprofen), Piroxicam has an exceptionally long terminal half-life of approximately 50 hours. This unique pharmacokinetic profile allows for true once-daily dosing, ensuring sustained, 24-hour pain relief and improving patient compliance in acute settings.
• Phagocytosis Inhibition: Beyond COX inhibition, Piroxicam also exerts direct effects on cellular immunity by inhibiting the migration of polymorphonuclear leukocytes (neutrophils) and macrophages into inflamed joints, further reducing tissue destruction in rheumatoid arthritis and gout.

Product Composition & Strength

We supply this product as a Sterile, Clear, Pale Yellow to Yellow Aqueous-Solvent Solution in glass ampoules.

*Pack Sizes: Tray of 10 Ampoules, 50 Ampoules, or 100 Ampoules.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Solvent System Optimization: Piroxicam is practically insoluble in water. Our specialized formulation utilizes a precise co-solvent system (often incorporating Propylene Glycol and Benzyl Alcohol) to ensure complete solubility and stability of the active ingredient while minimizing the extreme pain and muscle necrosis that can occur with poorly formulated intramuscular injections.
• Aseptic Processing: Manufactured under strict nitrogen purging to prevent oxidative degradation, filled in sterile Grade A environments to ensure an absolute pyrogen-free profile.

Therapeutic Indications (Human Use)

Indicated for the initial, short-term symptomatic relief of severe inflammatory and painful conditions:

• Rheumatoid Arthritis & Osteoarthritis: Management of severe acute flare-ups where oral administration is inappropriate.
• Ankylosing Spondylitis: Acute symptomatic relief of severe spinal inflammation.
• Acute Gout: Rapid suppression of intense inflammatory pain during acute gouty arthritis attacks.
• Acute Musculoskeletal Disorders: Severe trauma, strains, and sprains.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Route: Deep Intramuscular (IM) Injection ONLY. (Must be injected deeply into the upper outer quadrant of the gluteus maximus).
• CRITICAL WARNING: NEVER ADMINISTER INTRAVENOUSLY (IV). Intravenous administration can cause severe vascular damage and systemic shock.
• Standard Adult Dose: 20 mg once daily.
• Acute Gout / Severe Trauma: 40 mg once daily as a single dose, or in divided doses (20 mg twice daily) for the first 1 to 2 days, strictly transitioning to oral therapy thereafter.
• Duration constraint: IM therapy should generally not exceed 2 to 3 days. Patients should be switched to oral Piroxicam as soon as clinically feasible.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING (Gastrointestinal Risk): NSAIDs cause an increased risk of serious gastrointestinal adverse events, including bleeding, ulceration, and fatal perforation of the stomach or intestines. Risk is significantly higher in the elderly.
• BLACK BOX WARNING (Cardiovascular Risk): NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction (heart attacks), and stroke, which can be fatal. Contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
• Severe Skin Reactions: Piroxicam carries a higher risk than many other NSAIDs for severe skin reactions, including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Discontinue immediately at the first sign of skin rash.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Analgesic and Anti-inflammatory Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.