Description

Mercaptopurine (6-MP) Tablets (50 mg)

Healthy Inc is a specialized global supplier and exporter of advanced high-containment oncology, pediatric leukemia, and severe autoimmune therapeutics. We provide ultra-high-purity, kinetically precise Mercaptopurine Uncoated / Film-Coated Tablets (50 mg), manufactured in WHO–GMP certified, strictly segregated OEB 4/5 cytotoxic oral solid dosage facilities. This “Purine Antagonist Antimetabolite” is an ultra-high-value, highly restricted export to pediatric oncology centers, hematology wards, specialized IBD clinics, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, life-saving intervention for maintenance therapy in Acute Lymphoblastic Leukemia (ALL) and steroid-dependent Inflammatory Bowel Disease.

Product Overview

This highly advanced formulation acts as a lethal biochemical “Trojan Horse” for rapidly dividing cells. By perfectly mimicking the natural building blocks of DNA, it tricks cancer cells and hyperactive immune cells into absorbing it, completely shattering their ability to replicate.

The “DNA-Shredder & Leukemia Maintenance” Specialist:

• Mechanism 1 (The Purine Antagonism): Mercaptopurine is an analogue of the natural purine bases (adenine and guanine) required to build DNA and RNA. Once inside a leukemic blast or an activated T-cell, it is converted into toxic thioguanine nucleotides (TGNs). When the cell attempts to divide, it mistakenly incorporates these toxic TGNs into its new DNA strands. This physically breaks the DNA chain, immediately triggering apoptosis (programmed cell death).
• Mechanism 2 (The Pediatric ALL Anchor): Acute Lymphoblastic Leukemia is the most common childhood cancer. After aggressive IV chemotherapy drives the child into remission, the leukemia will rapidly return if left unchecked. Daily oral Mercaptopurine is the globally mandated “Maintenance Therapy,” taken for up to 2 to 3 years to silently hunt down and eradicate any remaining microscopic leukemic cells, effectively curing the patient.
• Mechanism 3 (The Corticosteroid-Sparing IBD Rescue): In gastroenterology, when patients with severe Crohn’s Disease or Ulcerative Colitis become dependent on highly toxic steroids (like Prednisolone), Mercaptopurine is deployed off-label as an aggressive immunosuppressant. By halting the proliferation of the T-lymphocytes attacking the gut, it allows the colon to heal and allows the patient to finally taper off destructive steroids.

Product Composition & Strength

We supply this product as a Precision-Blended, High-Density Tablet, packed exclusively in highly secure, handler-protective Alu-PVC or Alu-Alu blister strips to ensure the absolute chemical stability of the antimetabolite and protect healthcare workers from cytotoxic exposure.

*Pack Sizes: Bottles of 25/50 or 10×10 Blisters (Optimized specifically for strict, heavily monitored chronic oncology dispensing regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Oncology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• High-Containment Cytotoxic Engineering (CRITICAL COMPLIANCE): Mercaptopurine is a hazardous, highly toxic antimetabolite (Occupational Exposure Band 4/5). It is strictly prohibited and highly dangerous to manufacture this in a standard pharmaceutical facility. Our production occurs in entirely segregated High-Containment Blocks. We utilize strict negative-pressure cleanrooms, closed-loop powder transfer isolators, and advanced terminal HEPA filtration. This guarantees zero cross-contamination with general medicines and provides absolute occupational safety for our operators against airborne cytotoxic dust.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly specialized management of severe neoplastic and autoimmune diseases:

• Acute Lymphoblastic Leukemia (ALL): The cornerstone of maintenance therapy for pediatric and adult ALL, usually administered in combination with oral Methotrexate.
• Inflammatory Bowel Disease (Off-Label): Long-term maintenance of clinical remission in severe Crohn’s Disease and Ulcerative Colitis when mesalazine or steroids fail.

Dosage & Administration

Recommended Dosage (Strictly as per Oncologist/Gastroenterologist Guidelines):

• Standard Dosing: Highly variable. Strictly calculated based on the patient’s Body Surface Area (BSA) or weight (mg/kg).
• The “Intact Handling” Rule: Caregivers and parents MUST wear gloves or wash hands immediately after handling the tablet. Tablets should ideally not be broken or crushed outside of a clinical hood to avoid inhaling cytotoxic dust.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• The Allopurinol / Febuxostat Fatal Interaction (CRITICAL ALERT): Mercaptopurine is broken down in the liver by the enzyme xanthine oxidase. Gout medications like Allopurinol or Febuxostat completely block this enzyme. If a patient takes Allopurinol and a standard dose of Mercaptopurine, the Mercaptopurine levels will skyrocket to fatal toxic levels, completely obliterating the bone marrow. The Mercaptopurine dose MUST be reduced by 75% if co-administered.
• TPMT & NUDT15 Genetic Deficiency (FATAL TOXICITY): Roughly 1 in 300 patients completely lack the TPMT or NUDT15 enzymes required to safely metabolize this drug. Giving a standard dose to these patients will result in rapid, fatal bone marrow failure. Pharmacogenomic blood testing is highly recommended before initiating therapy.
• BLACK BOX WARNING (Severe Bone Marrow Suppression): Can cause profound leukopenia, thrombocytopenia, and anemia. Complete blood counts (CBC) must be monitored weekly during induction.
• Hepatotoxicity: High risk of toxic hepatitis, jaundice, and biliary stasis. Liver enzymes must be strictly monitored.
• Teratogenicity: Can cause profound fetal harm and pregnancy loss. Strict contraception is mandatory.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Oncology/Gastroenterology Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Antimetabolites, Cytotoxics, and High-Containment Formulations. Whether you are looking for a reliable Government Tender Supplier for pediatric leukemia wards in the CIS or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.