Description

Diloxanide Furoate Film-Coated Tablets (500 mg)

Healthy Inc is a specialized global supplier and exporter of advanced infectious disease, gastroenterology, and targeted anti-parasitic therapeutics. We provide ultra-high-purity, kinetically optimized Diloxanide Furoate Film-Coated Tablets (500 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Broad-Spectrum Luminal Amebicide” is a massive-volume, highly strategic export to infectious disease networks, tropical medicine clinics, mega-NGO procurement boards, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated intervention for the total eradication of Entamoeba histolytica cysts and the prevention of amoebiasis relapse.

Product Overview

This highly advanced formulation operates as a specialized biochemical “clearing agent” for the intestinal tract. It is designed specifically to target the dormant, highly resilient cystic stage of the amoeba that survives standard tissue-penetrating antibiotics, ensuring the infection is eradicated at its source.

The “Luminal Cyst Annihilator & Sequential Therapy” Specialist:

• Mechanism 1 (The Luminal Prodrug Cleavage): Diloxanide Furoate is an ester prodrug. When swallowed, it passes safely through the stomach and enters the intestines. Here, esterase enzymes in the gut lumen actively cleave the furoate molecule, releasing the free, highly active Diloxanide directly into the bowel cavity.
• Mechanism 2 (Direct Cyst Annihilation): Unlike tissue amebicides that are absorbed into the bloodstream, the unabsorbed Diloxanide remains trapped within the intestinal lumen. It directly contacts and destroys the asymptomatic, cyst-passing stage of Entamoeba histolytica, breaking down the parasite’s defenses and neutralizing it before it can be excreted to infect others.
• Mechanism 3 (The Sequential Therapy Mandate): In cases of severe amoebic dysentery or amoebic liver abscess, a tissue amebicide (like Metronidazole or Tinidazole) is used first to save the patient’s life. However, Metronidazole fails to clear the luminal cysts. Diloxanide Furoate is the globally mandated “Step Two” in this protocol—administered immediately after the tissue amebicide to completely sterilize the gut and prevent a catastrophic disease relapse.

Product Composition & Strength

We supply this product as a Precision-Blended, Luminal-Dispersion Macrodose Tablet, packed exclusively in highly secure, moisture-resistant Alu-PVC or heavy-gauge Alu-Alu blister strips to ensure the absolute chemical stability of the anti-parasitic ester.

*Pack Sizes: 10×10 Blisters (Optimized specifically for strict, 10-day acute parasitology eradication regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Infectious Disease Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Luminal Dispersion & Insoluble Macrodose Engineering (CRITICAL COMPLIANCE): Diloxanide Furoate is practically insoluble in water. If a generic tablet is poorly compressed, it will not disintegrate properly, passing entirely through the GI tract as a solid brick while leaving the parasitic cysts untouched. Our infectious disease suites utilize rigorous particle-size optimization and elite disintegrant matrices to guarantee the tablet fragments into microscopic, highly dispersed particles within the bowel, ensuring total therapeutic coverage and 100% cyst eradication.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly specialized eradication of intestinal protozoan infections:

• Asymptomatic Cyst Passers: First-line monotherapy for the eradication of Entamoeba histolytica cysts in asymptomatic carriers to prevent disease transmission.
• Sequential Therapy (Invasive Amoebiasis): Mandatory follow-up treatment immediately succeeding a course of tissue amebicides (e.g., Metronidazole, Tinidazole) in patients who have suffered from acute amoebic dysentery or amoebic liver abscess, to eradicate residual luminal cysts and prevent clinical relapse.

Dosage & Administration

Recommended Dosage (Strictly as per Infectious Disease Guidelines):

• Standard Adult Dosing: 500 mg taken orally three times a day (TID) for exactly 10 consecutive days.
• Compliance Mandate: The patient MUST complete the entire 10-day course even if they feel perfectly healthy. Premature discontinuation guarantees the survival of cysts and a highly probable relapse of dysentery.
• Administration: Best taken with meals to minimize gastrointestinal irritation and optimize gut transit time.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Invasive Amoebiasis Failure (FATAL WARNING): Diloxanide Furoate is a luminal agent; it does not achieve high concentrations in the bloodstream or deep tissues. It is strictly contraindicated as a monotherapy for acute amoebic dysentery or liver abscess. Using it alone for invasive disease will result in catastrophic, potentially fatal treatment failure.
• Gastrointestinal Distress: The primary side effect profile includes significant flatulence (gas), nausea, vomiting, and diarrhea due to the drug’s intense activity within the gut lumen.
• Pregnancy Caution: Safety in pregnancy has not been absolutely established. It should be avoided during the first trimester unless the clinical necessity strictly outweighs the potential risk to the fetus.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Tropical Medicine Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Antiprotozoals, Luminal Amebicides, and Insoluble Macrodose Formulations. Whether you are looking for a reliable Government Tender Supplier for national parasite eradication programs in Africa or a B2B Pharma Marketplace partner for Southeast Asia, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.