Description
Chlorthalidone Tablets (6.25 mg / 12.5 mg / 25 mg)
Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, renal, and targeted diuretic therapeutics. We provide ultra-high-purity, kinetically stabilized Chlorthalidone Tablets (6.25 mg / 12.5 mg / 25 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Thiazide-Like Diuretic” is a high-volume, clinically superior export to cardiology networks, hypertension clinics, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the evidence-based “Gold Standard” for the management of Essential Hypertension and Edema.
Product Overview
Chlorthalidone operates as a long-acting renal modulator. Unlike standard thiazides that wear off mid-evening, Chlorthalidone provides a sustained, 24-hour reduction in blood volume and peripheral resistance, ensuring the patient remains protected throughout the night and into the early morning.
The “Long-Acting Volume & Pressure” Specialist:
- Mechanism 1 (The Distal Tubule Blockade): Chlorthalidone binds to the sodium-chloride symporter in the distal convoluted tubule of the kidney. By blocking the reabsorption of salt back into the blood, it forces the body to excrete excess sodium and water through urine. This immediate drop in blood volume leads to a sustained decrease in blood pressure.
- Mechanism 2 (The Carbonic Anhydrase Effect): Uniquely among diuretics, Chlorthalidone also possesses mild carbonic anhydrase inhibitory activity. This contributes to its potent antihypertensive effect by further modulating vascular resistance, a feature not shared by many older diuretics.
- Mechanism 3 (The 40-Hour Half-Life Advantage): While HCTZ lasts 6–12 hours, Chlorthalidone remains active for up to 60 hours. This “Pharmacokinetic Flat-Curve” prevents the dangerous “rebound” hypertension that occurs when shorter-acting drugs wear off before the next dose.
Product Composition & Strength
We supply this product as a Precision-Blended, High-Bioavailability Tablet, packed in moisture-resistant Alu-PVC or Alu-Alu blister strips to ensure the stability of the micronized active ingredient.
| Active Ingredient | Strength | Primary Clinical Function |
|---|---|---|
| Chlorthalidone USP/BP | 6.25 mg / 12.5 mg | The Contemporary Starting Dose: Highly preferred for modern “Low-Dose” hypertension therapy to maximize pressure control while minimizing electrolyte loss. |
| Chlorthalidone USP/BP | 25 mg | The High-Potency Payload: Utilized for resistant hypertension or the management of edema associated with heart failure or hepatic cirrhosis. |
| Excipients | Microcrystalline Cellulose / Colloidal Silicon Dioxide / Magnesium Stearate / Pregelatinized Starch | Diluent / Glidant / Lubricant / Binder (Engineered specifically utilizing Micronized API Technology to ensure absolute uniformity in the 6.25mg and 12.5mg ultra-low-dose tablets, guaranteeing consistent renal response across every batch). |
Technical & Logistics Specifications
| HS Code | 3004.90.99 (Medicaments containing other active substances – Cardiovascular/Diuretics) |
| CAS Number | 77-36-1 (Chlorthalidone) |
| Dosage Form | Uncoated or Film-Coated Tablet (Immediate Release) |
| Packaging | Alu-PVC or Alu-Alu Blisters. Protects the formulation from environmental humidity across Zone IVb tropical climates. |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Ultra-Low Dose Content Uniformity (CRITICAL COMPLIANCE): Manufacturing a 6.25mg tablet requires extreme precision. A 1mg error represents a ~15% deviation in dose. Our cardiology suites utilize Geometric Dilution and Multi-Stage Blending to guarantee 100% uniformity. We provide global buyers with a product that delivers the exact evidence-based dose required for safe, chronic hypertension management.
Therapeutic Indications
- Essential Hypertension: First-line therapy, either as monotherapy or in combination with ARBs/ACEIs.
- Edema: Management of fluid retention associated with Congestive Heart Failure (CHF), renal dysfunction, or corticosteroid therapy.
- Renal Stone Prophylaxis: Off-label use to reduce calcium excretion in patients with recurrent kidney stones.
Dosage & Administration
- Hypertension: Initially 12.5 mg to 25 mg once daily, preferably in the morning to avoid nocturnal urination (nocturia).
- Maximum Dose: Generally 50 mg per day; higher doses increase electrolyte risks without significantly better pressure control.
Safety Warnings (CRITICAL):
- Electrolyte Imbalance: Can cause life-threatening Hypokalemia (low potassium), Hyponatremia (low sodium), and Hypomagnesemia. Regular blood chemistry monitoring is mandatory.
- Hyperuricemia (Gout Alert): Chlorthalidone can increase uric acid levels, potentially triggering acute gout attacks in susceptible patients.
- Sulfa Allergy: Use with caution in patients with a history of sulfonamide allergy, as cross-reactivity may occur.
- Diabetes Alert: May impair glucose tolerance, requiring adjustment of insulin or oral hypoglycemic doses.
Global Export & Contract Manufacturing Services
Healthy Inc is a premier Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-end diuretics and low-dose antihypertensives. Whether you are a Government Tender Supplier for cardiovascular health programs in Africa or a B2B Pharma Marketplace partner in Latin America, we ensure secure, WHO-GMP compliant delivery.
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