Description

Chloramphenicol Sodium Succinate Injection

Healthy Inc is a specialized global supplier and exporter of potent bacteriostatic antibiotics. We provide high-purity Chloramphenicol Sodium Succinate Injection (1g), sourced from WHO–GMP certified sterile injectable facilities. This “Meningitis & Typhoid Specialist” is a top export to infectious disease wards, rural hospitals, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a critical, cost-effective treatment for life-threatening infections like Typhoid Fever and Meningitis where other drugs may be unavailable or ineffective.

Product Overview

This formulation contains Chloramphenicol Sodium Succinate, a prodrug that is hydrolyzed in the body to release active Chloramphenicol.

The “Blood-Brain Barrier” Specialist:

• Mechanism (Protein Synthesis Halt): Chloramphenicol is a potent inhibitor of bacterial protein synthesis. It binds reversibly to the 50S ribosomal subunit, preventing the attachment of amino acids to the growing peptide chain. This stops bacterial growth (bacteriostatic).
• CNS Penetration: It has exceptional lipid solubility, allowing it to cross the Blood-Brain Barrier easily. Levels in the Cerebrospinal Fluid (CSF) can reach 50-60% of plasma levels even without meningeal inflammation, making it highly effective for bacterial meningitis.
• Typhoid Fever: Historically the drug of choice for Salmonella typhi. It remains a vital option in developing regions for treating severe Typhoid where newer drugs are too expensive or resistant.

Product Composition & Strength

We supply this product as a Sterile Lyophilized Powder for Injection in glass vials. It must be reconstituted before use.

*Pack Sizes: Tray of 1 Vial, 10 Vials, 50 Vials, or Box of 1/10 Vials with Water for Injection (WFI).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Prodrug Stability: Chloramphenicol Sodium Succinate is highly soluble in water but susceptible to hydrolysis. We use advanced lyophilization cycles to remove moisture to <1%, ensuring the ester linkage remains intact during storage, preventing premature activation or degradation.
• Endotoxin Control: Given its use in meningitis (intrathecal/IV), our manufacturing process ensures strict endotoxin limits to prevent fever or shock during administration.

Therapeutic Indications (Human Use)

Indicated for serious infections where other antibiotics are ineffective or contraindicated:

• Typhoid Fever: Severe enteric fever caused by Salmonella typhi.
• Bacterial Meningitis: Caused by H. influenzae, N. meningitidis, or S. pneumoniae (especially in penicillin-allergic patients).
• Brain Abscess: Due to excellent CNS penetration (often combined with Metronidazole).
• Rickettsial Infections: Rocky Mountain Spotted Fever (alternative to Tetracyclines).
• Anaerobic Infections: Intra-abdominal infections involving Bacteroides fragilis.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Route: Intravenous (IV) Injection ONLY. (IM injection is ineffective due to poor hydrolysis).
• Adults: 50 mg/kg/day divided into 4 doses (every 6 hours).
• Severe Infections (Meningitis): Up to 100 mg/kg/day.
• Children: 50 mg/kg/day divided into 4 doses.
• Reconstitution: Dissolve 1g vial in 10ml WFI/Saline (100 mg/ml). Inject over at least 1 minute.

Safety Warnings (CRITICAL):

• Bone Marrow Suppression (FATAL): Can cause dose-related reversible suppression OR idiosyncratic irreversible Aplastic Anemia (rare but fatal). Regular blood counts are mandatory.
• Gray Baby Syndrome: CONTRAINDICATED in neonates/premature infants. Their immature liver cannot metabolize the drug, leading to accumulation, cardiovascular collapse, and death (Gray Baby Syndrome).
• Interaction: Inhibits liver enzymes (CYP450), increasing levels of Warfarin, Phenytoin, and Sulfonylureas.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.