Description

Chloramphenicol Capsules

Healthy Inc is a specialized global supplier and exporter of essential, life-saving broad-spectrum antimicrobials. We provide high-purity Chloramphenicol Capsules (250 mg), manufactured in WHO–GMP certified oral solid dosage facilities. This “First-Generation Amphenicol” is a critical, high-priority export to infectious disease hospitals, epidemic response NGOs, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a highly targeted, definitive intervention for severe, multi-drug resistant Typhoid Fever and acute Bacterial Meningitis.

Product Overview

This formulation contains Chloramphenicol, a potent, synthetic broad-spectrum bacteriostatic antibiotic (though it can be bactericidal against specific meningitis-causing pathogens like H. influenzae).

The “Deep CNS Penetration” Specialist:

• Mechanism (Peptidyl Transferase Blockade): Chloramphenicol is highly lipid-soluble. It effortlessly penetrates the bacterial cell membrane and binds reversibly to the 50S ribosomal subunit. Once attached, it specifically inhibits the enzyme peptidyl transferase, completely blocking the formation of peptide bonds and halting bacterial protein synthesis.
• Elite Blood-Brain Barrier (BBB) Crossing: Its extreme lipophilicity and low molecular weight allow it to cross the blood-brain barrier with unparalleled efficiency, achieving cerebrospinal fluid (CSF) concentrations up to 60% of serum levels even without inflamed meninges. This makes it a gold-standard oral option for brain abscesses and severe meningitis when standard cephalosporins are unavailable or contraindicated.
• The Typhoid & Rickettsial Weapon: Historically, it is the classic drug of choice for Salmonella typhi (Typhoid Fever) and is highly lethal against severe intracellular pathogens like Rickettsia (Typhus/Rocky Mountain Spotted Fever) and aggressive anaerobes.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in specialized moisture-resistant blister strips to prevent the hydrolysis of the API.

*Pack Sizes: 10×10 Alu-PVC Blisters or Bulk Jars of 1000 Capsules for epidemic/outbreak response.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Outbreak Response NGOs.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Polymorph Stability Control: Chloramphenicol exhibits multiple crystalline polymorphs, some of which are biologically inactive. Our manufacturing relies on rigorous X-ray powder diffraction (XRPD) profiling to ensure only the thermodynamically stable, highly bioavailable polymorph is utilized in our capsules.
• Toxicity & Impurity Profiling: Because the drug carries severe hematological risks, absolute API purity is mandatory. Extensive HPLC testing guarantees the absence of toxic degradation byproducts that could inadvertently increase the risk of bone marrow suppression.

Therapeutic Indications (Human Use)

Indicated only for the treatment of serious infections where less potentially toxic drugs are ineffective or contraindicated:

• Typhoid Fever: Severe systemic infections caused by susceptible strains of Salmonella typhi.
• Bacterial Meningitis: Infections of the meninges caused by Haemophilus influenzae, Neisseria meningitidis, or Streptococcus pneumoniae (particularly in penicillin-allergic patients).
• Rickettsial Infections: Typhus and Q-fever when tetracyclines are contraindicated.
• Severe Anaerobic Infections: Deep-seated brain abscesses or intra-abdominal infections involving Bacteroides fragilis.

Dosage & Administration

Recommended Dosage (Strictly as per Infectious Disease Specialist):

• Administration: Taken orally, on an empty stomach (1 hour before or 2 hours after meals) to ensure maximum absorption.
• Standard Adult Dose: 50 mg/kg/day in divided doses every 6 hours (e.g., typically two 250mg capsules every 6 hours for an average adult).
• Severe Infections: Up to 100 mg/kg/day may be used initially for highly aggressive infections, but must be reduced as soon as clinically possible.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING (Fatal Blood Dyscrasias): Chloramphenicol is notorious for causing two types of bone marrow depression: a dose-related, reversible suppression (anemia/neutropenia), and a rare, idiosyncratic, irreversible, and highly fatal Aplastic Anemia. Baseline and baseline-frequent complete blood counts (CBCs) are strictly mandatory.
• Gray Baby Syndrome: Absolutely contraindicated in premature infants and neonates. Newborns lack the glucuronic acid conjugation mechanism in the liver to detoxify the drug. It accumulates rapidly, causing cardiovascular collapse, cyanosis (ashen-gray skin color), and death.
• Neurotoxicity: Prolonged therapy can lead to severe peripheral neuropathy and optic neuritis (potentially leading to blindness).

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Essential Antimicrobial Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Epidemic Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.