ATENOLOL & S-AMLODIPINE TABLETS

Description

Atenolol & S-Amlodipine Besylate Tablets (50 mg / 2.5 mg or 50 mg / 5 mg)

Healthy Inc is a specialized global supplier and exporter of advanced cardiology, internal medicine, and targeted cardiovascular therapeutics. We provide ultra-high-purity, kinetically balanced Atenolol & S-Amlodipine FDC Tablets, manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Cardio-Selective Beta Blocker & Chiral Calcium Channel Blocker (CCB) FDC” is a massive-volume strategic export to hypertension clinics, cardiac hospitals, and government health ministries, serving as the globally mandated intervention for Essential Hypertension and Chronic Stable Angina.

Product Overview

This formulation operates as a “Hemodynamic Harmonizer.” It addresses the two primary drivers of high blood pressure: an overactive heart (Atenolol) and constricted blood vessels (S-Amlodipine).

• Mechanism 1 (The Pure Vasodilator – S-Amlodipine): S-Amlodipine is the chirally pure, active isomer of Amlodipine. It inhibits the entry of calcium ions into the vascular smooth muscle, causing Peripheral Vasodilation. Because it lacks the R-isomer, it achieves the same BP reduction as 5 mg or 10 mg of standard Amlodipine but with a drastically lower incidence of pedal edema.

• Mechanism 2 (The Cardiac Governor – Atenolol): As a Beta-1 Selective Adrenoceptor Antagonist, Atenolol reduces the heart rate and the force of contraction. This lowers the cardiac output and the heart’s oxygen demand, effectively “quieting” the cardiovascular system.

• Mechanism 3 (The Synergistic Barrier): While S-Amlodipine relaxes the vessels, it can sometimes cause a “reflex tachycardia” (fast heart rate). Atenolol physically blocks this reflex, ensuring that the blood pressure drops without causing heart palpitations.

Product Composition & Strength

We supply this product as a Precision-Blended, Film-Coated Tablet, utilizing high-purity S-Amlodipine Besylate to ensure stability.

Technical & Logistics Specifications

• HS Code: 3004.90.69 (Medicaments containing other active substances – Cardiovascular)

• CAS Numbers: 29122-68-7 (Atenolol) / 103129-82-4 (S-Amlodipine)

• Dosage Form: Film-Coated Tablet

• Packaging: Alu-Alu or Alu-PVC Blisters. Requires protection from environmental light and humidity; our moisture-lock packaging ensures 24-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Chiral Purity Monitoring: We utilize Chiral HPLC (High-Performance Liquid Chromatography) to guarantee that our S-Amlodipine is 100% pure S-isomer, ensuring the “Zero-Edema” clinical promise.

• Synchronized Dissolution: Our facility utilizes Advanced Wet Granulation to ensure that both the water-soluble Atenolol and the hydrophobic S-Amlodipine release in a perfectly synchronized manner for 24-hour coverage.

Primary Indications

• Cardiology: Management of mild to moderate Essential Hypertension.

• Ischemic Heart Disease: Treatment of Chronic Stable Angina Pectoris.

• Preventative: Reducing the risk of stroke and myocardial infarction in patients with uncontrolled BP.

Dosage & Administration

• Standard Adult Dosing: 1 tablet once daily, preferably in the morning to prevent the physiological morning BP surge.

• Administration: Must be swallowed whole. Do not crush or chew.

Safety Warning: The Beta-Blocker Warning. Do not stop this medication abruptly. Sudden withdrawal of Atenolol can lead to rebound hypertension or exacerbation of angina. Use with caution in patients with asthma or bradycardia (slow heart rate).

Global Export & Contract Manufacturing

Healthy Inc is a premier Cardiovascular Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for specialized Chiral FDCs. Whether you are a Cardiology Hospital Chain in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.