Description

Atazanavir & Ritonavir Tablets 

Healthy Inc is a specialized global supplier and exporter of advanced anti-retrovirals (ARVs), infectious disease, and targeted immunomudulatory therapeutics. We provide ultra-high-purity, kinetically balanced Atazanavir & Ritonavir FDC Tablets, manufactured in WHO–GMP and SRA-compliant (Strict Regulatory Authority) specialized ARV containment facilities. This “Boosted Protease Inhibitor (PI) FDC” is a massive-volume strategic export to HIV/AIDS treatment centers, NGO health programs, and government health ministries, serving as a globally mandated component of Highly Active Antiretroviral Therapy (HAART).

Product Overview

This formulation operates as a “Molecular Scissor Blocker.” It prevents the HIV virus from maturing and infecting new cells, effectively halting the progression of the disease and allowing the patient’s immune system to recover.

• Mechanism 1 (The Protease Blockade – Atazanavir): Atazanavir selectively binds to the HIV-1 Protease enzyme. This enzyme is responsible for “cutting” long viral protein chains into smaller, functional pieces. By blocking this “scissor,” the virus produces only immature, non-infectious virions.

• Mechanism 2 (The PK Booster – Ritonavir): Ritonavir is a potent inhibitor of the CYP3A4 enzyme in the liver. Since CYP3A4 is what normally breaks down Atazanavir, Ritonavir “boosts” the Atazanavir concentration in the blood, allowing for a lower, more tolerable, and once-daily dose.

• Mechanism 3 (The Genetic Barrier): Protease inhibitors like Atazanavir have a “High Genetic Barrier to Resistance.” This means the virus must undergo multiple complex mutations to bypass the drug, making it an essential choice for patients who have failed initial HIV treatments.

 Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments containing other active substances – Anti-retrovirals)

• CAS Numbers: 198904-31-3 (Atazanavir) / 155213-67-5 (Ritonavir)

• Dosage Form: Film-Coated Tablet (Heat-stable formulation)

• Packaging: HDPE Bottles or Alu-Alu Blisters. Our “Heat-Stable” technology ensures 24-month potency even in Zone IVb tropical climates without the need for refrigeration.

Manufacturing Authority & Compliance

• ARV Containment Integrity: Our facility utilizes Dedicated ARV Production Blocks with restricted access and advanced air-filtration systems to ensure zero cross-contamination and 100% API purity.

• WHO-Prequalification Ready: We provide comprehensive stability data and bioequivalence dossiers (matching the innovator brand, e.g., Reyataz/Norvir combination) to support NGO and Government tenders.

Primary Indications

• Infectious Disease: Treatment of HIV-1 infection in adults and pediatric patients (weighing at least 35 kg) as part of a combination ARV regimen.

• Second-Line Therapy: Preferred protease inhibitor for patients who have developed resistance to first-line NRTIs or NNRTIs.

Dosage & Administration

• Standard Adult Dosing: 1 tablet once daily, taken at the same time every day.

• The “Meal” Mandate (CRITICAL): These tablets MUST be taken with food. Food significantly increases the absorption of Atazanavir, ensuring therapeutic levels are reached.

Safety Warning: Drug Interactions. Atazanavir requires an acidic stomach environment; avoid use with Proton Pump Inhibitors (PPIs). Monitor for Hyperbilirubinemia (yellowing of the eyes/skin), which is a common but usually non-harmful side effect of Atazanavir. Use with caution in patients with hepatic impairment.

Global Export & Contract Manufacturing

Healthy Inc is a premier ARV Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for specialized HIV FDCs. Whether you are an International NGO Procurement Officer in Africa or a B2B Pharma Marketplace partner in Southeast Asia, we ensure secure, WHO-GMP compliant delivery.