Description

Atazanavir Capsules

Healthy Inc is a specialized global supplier and exporter of life-saving infectious disease and antiretroviral (ARV) therapeutics. We provide high-purity Atazanavir Capsules (150 mg / 200 mg / 300 mg), manufactured in WHO–GMP certified oral solid dosage facilities. This “Azapeptide Protease Inhibitor” is a critical, high-volume export to infectious disease hospitals, HIV/AIDS treatment centers, and government health ministries in Africa, LATAM, and Southeast Asia, serving as a highly potent, once-daily backbone component in combination antiretroviral therapy (cART).

Product Overview

This formulation contains Atazanavir (as Atazanavir Sulfate), a targeted, highly selective HIV-1 protease inhibitor (PI).

The “Viral Assembly” Specialist:

• Mechanism (Protease Inhibition): During the final stages of the HIV replication cycle, the virus relies on the HIV-1 protease enzyme to cleave large, inactive polyproteins (gag-pol) into smaller, active proteins. Atazanavir binds directly to the active site of this enzyme. By physically blocking this cleavage, the virus is unable to mature, resulting in the release of immature, non-infectious viral particles that cannot infect other CD4 cells.
• The “Boosted” Regimen Advantage: Atazanavir is rapidly metabolized by the liver enzyme CYP3A4. To maintain high, steady-state therapeutic concentrations throughout a 24-hour period, it is almost universally co-administered with a low dose of Ritonavir (a potent CYP3A4 inhibitor). This “boosting” allows Atazanavir to be dosed just once daily, massively improving patient adherence compared to older PIs.
• Favorable Lipid Profile: Unlike many older protease inhibitors (like Lopinavir or Indinavir), Atazanavir is highly regarded for having a far more favorable metabolic profile, causing significantly less dyslipidemia (elevated cholesterol and triglycerides) and fat redistribution, making it ideal for long-term chronic care.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in specialized high-density polyethylene (HDPE) bottles to preserve API stability over extended logistical chains.

*Pack Sizes: 30-Capsule HDPE Bottles with Child-Resistant Closures (the global standard for 30-day ARV dispensing).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and ARV Tender Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Solubility Enhancement: Atazanavir’s solubility is highly pH-dependent. Our formulation utilizes specialized superdisintegrants to ensure immediate capsule rupture within the acidic environment of the stomach, which is absolutely required to achieve peak plasma concentrations and prevent virologic failure.
• Assay Precision: Because ARV resistance develops rapidly if plasma levels drop, our manufacturing process utilizes advanced high-shear blending to guarantee absolute content uniformity across every batch, ensuring patients receive the exact milligram strength required for complete viral suppression.

Therapeutic Indications (Human Use)

Indicated for the treatment of HIV-1 infection:

• HIV-1 Infection: Must be used strictly in combination with other antiretroviral agents (never as monotherapy) for the treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection in adult and pediatric patients.

Dosage & Administration

Recommended Dosage (Strictly as per Infectious Disease Specialist):

• Administration (CRITICAL FOOD RULE): Atazanavir capsules MUST be taken with food. Food significantly enhances the bioavailability of the drug and reduces pharmacokinetic variability.
• Standard Adult Dose (Boosted): 300 mg Atazanavir + 100 mg Ritonavir, taken once daily with food.
• Gastric pH Interaction (CRITICAL): The absorption of Atazanavir requires an acidic stomach. Proton Pump Inhibitors (PPIs) are generally contraindicated or require extreme dosage adjustments. H2-receptor antagonists and antacids must be temporally separated by several hours from the Atazanavir dose.

Safety Warnings (CRITICAL):

• Hyperbilirubinemia (Jaundice): Atazanavir reversibly inhibits the UGT1A1 enzyme in the liver, leading to elevated indirect bilirubin. This frequently causes asymptomatic jaundice (yellowing of the skin and sclera of the eyes). While visually alarming, it is usually cosmetic and does not indicate hepatic injury, though patients must be counseled to ensure compliance.
• PR Interval Prolongation: Can cause prolongation of the PR interval on an ECG, potentially leading to atrioventricular (AV) block. Use with caution in patients with underlying conduction defects.
• Nephrolithiasis & Cholelithiasis: Cases of severe kidney stones and gallstones have been reported. Adequate patient hydration is strongly recommended.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Antiretroviral (ARV) Medicines, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable NGO Tender Supplier for global health procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.