Sulfadoxine Pyrimethamine Suspension

Description

Sulfadoxine & Pyrimethamine Oral Suspension (500 mg + 25 mg)

Healthy Inc is a specialized global supplier and exporter of advanced anti-malarials, pediatric medicine, and tropical health therapeutics. We provide ultra-high-purity, kinetically stabilized Sulfadoxine & Pyrimethamine Suspension, manufactured in WHO–GMP certified, high-precision liquid manufacturing facilities. This “Synergistic Antifolate” combination is a critical strategic export to government health ministries, NGO procurement agencies, and international B2B distributors, serving as a cornerstone for the prevention and treatment of Plasmodium falciparum malaria.

Product Overview

This formulation operates as a “Sequential Metabolic Inhibitor.” It physically starves the malaria parasite of the folic acid it needs to replicate its DNA.

• Mechanism 1 (Dihydropteroate Synthase Inhibition – Sulfadoxine): A sulfonamide that physically mimics PABA to block the first step of folic acid synthesis in the parasite.

• Mechanism 2 (Dihydrofolate Reductase Inhibition – Pyrimethamine): Physically binds to the second enzyme in the pathway, chemically ensuring that even if some precursor is made, it cannot be converted into active DNA-building blocks.

• Mechanism 3 (Synergistic Efficacy): By physically blocking two sequential steps, the combination is significantly more potent than either drug alone and helps delay the development of parasitic resistance.

Product Composition & Strength

We supply this product as a Micronized Homogeneous Suspension, optimized for long-lasting plasma levels and pediatric compliance.

Technical & Logistics Specifications

• HS Code: 3004.20.19 (Medicaments containing other antibiotics / Anti-malarials)

• CAS Numbers: 2447-57-6 (Sulfadoxine) / 58-14-0 (Pyrimethamine)

• Dosage Form: Oral Liquid (Suspension)

• Packaging: 10 ml / 15 ml / 30 ml Amber PET or Glass Bottles. Our specialized packaging ensures 36-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Micronized Homogenization: Both active ingredients are physically insoluble. Our manufacturing process utilizes High-Shear Homogenization to ensure the drug particles are perfectly micronized, preventing “grittiness” and ensuring an exact dose in every spoon.

• Potency Stability: We utilize Advanced Buffering Systems to ensure the chemical integrity of the Sulfadoxine molecule, which is physically sensitive to pH fluctuations over long storage periods.

• Aseptic Filling: We utilize Automated Liquid Filling Lines with 100% microbial testing to ensure total safety for vulnerable populations, including pregnant women and infants.

Primary Indications

• Public Health: Intermittent Preventive Treatment (IPT) for malaria in pregnant women and infants in endemic regions.

• Pediatrics: Treatment of uncomplicated Plasmodium Falciparum Malaria in areas where the parasite remains sensitive to antifolates.

• Tropical Medicine: Prophylaxis for travelers and residents in high-risk zones.

Dosage & Administration

• Standard Adult Dose: Typically 3 tablets (or equivalent 15ml suspension) as a single dose.

• Pediatric Dose: Physically calculated based on body weight (typically 25mg/kg Sulfadoxine and 1.25mg/kg Pyrimethamine).

• Single Dose Therapy: One of the primary physical advantages of this combination is that it is often administered as a Single Stat Dose, significantly increasing patient compliance.

• Shake Well: The bottle must be physically shaken before each use to ensure uniform drug distribution.

Safety Warning: For Oral Use Only. Hydration Note: Patients should physically drink plenty of water to prevent the formation of sulfonamide crystals in the kidneys. Skin Warning: Immediately discontinue use if any Skin Rash or itching occurs (risk of Stevens-Johnson Syndrome). Contraindication: Do not use in patients with severe renal or hepatic failure, or known hypersensitivity to Sulfonamides or Pyrimethamine.

Global Export & Contract Manufacturing

Healthy Inc is a premier Anti-Malarial and Pediatric Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume anti-malarial suspensions. Whether you are a National Malaria Control Program in Africa or a B2B Pharma Marketplace partner in SE Asia or the Middle East, we ensure secure, WHO-GMP compliant delivery.