Sulfadoxine & Pyrimethamine Oral Suspension (500 mg + 25 mg)
Healthy Inc is a specialized global supplier and exporter of advanced anti-malarials, pediatric medicine, and tropical health therapeutics. We provide ultra-high-purity, kinetically stabilized Sulfadoxine & Pyrimethamine Suspension, manufactured in WHO–GMP certified, high-precision liquid manufacturing facilities. This “Synergistic Antifolate” combination is a critical strategic export to government health ministries, NGO procurement agencies, and international B2B distributors, serving as a cornerstone for the prevention and treatment of Plasmodium falciparum malaria.
Product Overview
This formulation operates as a “Sequential Metabolic Inhibitor.” It physically starves the malaria parasite of the folic acid it needs to replicate its DNA.
Mechanism 1 (Dihydropteroate Synthase Inhibition – Sulfadoxine): A sulfonamide that physically mimics PABA to block the first step of folic acid synthesis in the parasite.
Mechanism 2 (Dihydrofolate Reductase Inhibition – Pyrimethamine): Physically binds to the second enzyme in the pathway, chemically ensuring that even if some precursor is made, it cannot be converted into active DNA-building blocks.
Mechanism 3 (Synergistic Efficacy): By physically blocking two sequential steps, the combination is significantly more potent than either drug alone and helps delay the development of parasitic resistance.
Product Composition & Strength
We supply this product as a Micronized Homogeneous Suspension, optimized for long-lasting plasma levels and pediatric compliance.
| Active Ingredient | Strength (per 5 ml) | Primary Clinical Function |
| Sulfadoxine IP/BP | 500 mg | The Enzyme Blocker 1: Interrupts early folate synthesis. |
| Pyrimethamine IP/BP | 250 mg | The Enzyme Blocker 2: Blocks late-stage DNA building. |
| Excipients | Xanthan Gum / Sorbitol | The Matrix: Ensures uniform suspension and exact dosing. |
| Flavoring | Orange / Mixed Fruit / Raspberry | The Palatable Base: Essential for child acceptance. |
Technical & Logistics Specifications
HS Code: 3004.20.19 (Medicaments containing other antibiotics / Anti-malarials)
CAS Numbers: 2447-57-6 (Sulfadoxine) / 58-14-0 (Pyrimethamine)
Dosage Form: Oral Liquid (Suspension)
Packaging: 10 ml / 15 ml / 30 ml Amber PET or Glass Bottles. Our specialized packaging ensures 36-month stability in Zone IVb tropical climates.
Manufacturing Authority & Compliance
Micronized Homogenization: Both active ingredients are physically insoluble. Our manufacturing process utilizes High-Shear Homogenization to ensure the drug particles are perfectly micronized, preventing “grittiness” and ensuring an exact dose in every spoon.
Potency Stability: We utilize Advanced Buffering Systems to ensure the chemical integrity of the Sulfadoxine molecule, which is physically sensitive to pH fluctuations over long storage periods.
Aseptic Filling: We utilize Automated Liquid Filling Lines with 100% microbial testing to ensure total safety for vulnerable populations, including pregnant women and infants.
Primary Indications
Public Health: Intermittent Preventive Treatment (IPT) for malaria in pregnant women and infants in endemic regions.
Pediatrics: Treatment of uncomplicated Plasmodium Falciparum Malaria in areas where the parasite remains sensitive to antifolates.
Tropical Medicine: Prophylaxis for travelers and residents in high-risk zones.
Dosage & Administration
Standard Adult Dose: Typically 3 tablets (or equivalent 15ml suspension) as a single dose.
Pediatric Dose: Physically calculated based on body weight (typically 25mg/kg Sulfadoxine and 1.25mg/kg Pyrimethamine).
Single Dose Therapy: One of the primary physical advantages of this combination is that it is often administered as a Single Stat Dose, significantly increasing patient compliance.
Shake Well: The bottle must be physically shaken before each use to ensure uniform drug distribution.
Safety Warning: For Oral Use Only. Hydration Note: Patients should physically drink plenty of water to prevent the formation of sulfonamide crystals in the kidneys. Skin Warning: Immediately discontinue use if any Skin Rash or itching occurs (risk of Stevens-Johnson Syndrome). Contraindication: Do not use in patients with severe renal or hepatic failure, or known hypersensitivity to Sulfonamides or Pyrimethamine.
Global Export & Contract Manufacturing
Healthy Inc is a premier Anti-Malarial and Pediatric Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume anti-malarial suspensions. Whether you are a National Malaria Control Program in Africa or a B2B Pharma Marketplace partner in SE Asia or the Middle East, we ensure secure, WHO-GMP compliant delivery.