Description

Nicotinamide (Vitamin B3) Tablets (250 mg / 500 mg)

Healthy Inc is a specialized global supplier and exporter of advanced dermatological, oncological-support, and metabolic therapeutics. We provide ultra-high-purity, kinetically stabilized Nicotinamide Film-Coated / Uncoated Tablets (250 mg / 500 mg), manufactured in WHO–GMP certified, high-precision vitamin and oral solid dosage facilities. This “Cellular Energy & DNA-Repair Precursor” is a massive-volume, highly lucrative export to dermatology clinics, oncology centers, primary care networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated intervention for clinical Pellagra, severe inflammatory skin conditions, and high-risk skin cancer prophylaxis.

Product Overview

This highly advanced formulation delivers a massive pharmacological dose of the amide form of Vitamin B3, directly supercharging the cellular engines of the body to repair profound tissue damage and halt severe inflammatory cascades.

The “DNA-Repair & Non-Flushing B3” Specialist:

• Mechanism 1 (The NAD+/NADP+ Cellular Engine): Nicotinamide is the direct, essential precursor to NAD+ and NADP+—the fundamental coenzymes required for cellular respiration and ATP (energy) production. In malnourished patients suffering from Pellagra (the “4 Ds”: Dermatitis, Diarrhea, Dementia, Death), the body’s energy grid has collapsed. Nicotinamide instantly restarts this grid, rapidly reversing the fatal neurological and gastrointestinal breakdown.
• Mechanism 2 (Oncological Skin Prophylaxis – CRITICAL): When UV radiation from the sun damages skin DNA, the cell requires massive amounts of ATP to power the PARP-1 enzyme, which repairs the broken DNA strands. Mega-doses of Nicotinamide flood the skin cells with excess energy, drastically accelerating this DNA repair before the cell can mutate into basal cell or squamous cell carcinoma. It is the globally recognized oral prophylactic for high-risk dermatology patients.
• Mechanism 3 (The “No-Flush” Anti-Inflammatory): Unlike its cousin Nicotinic Acid, Nicotinamide does not stimulate prostaglandins. It delivers profound, systemic Vitamin B3 without causing the violent, painful full-body “flush.” Furthermore, it acts as a potent inhibitor of inflammatory cytokines (like IL-6 and TNF-alpha), making it a highly effective systemic therapy for severe Acne Vulgaris, Rosacea, and Bullous Pemphigoid.

Product Composition & Strength

We supply this product as a Precision-Blended, Immediate-Release Tablet, packed exclusively in highly secure, moisture-resistant Alu-PVC or high-density HDPE bottles to ensure the absolute chemical stability of the highly soluble vitamin amide.

*Pack Sizes: 10×10 Blisters or Bottles of 60/100 (Optimized specifically for chronic, twice-daily dermatological dispensing regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Dermatology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Amide Stabilization & Purity Engineering (CRITICAL COMPLIANCE): Nicotinamide is chemically related to Nicotinic Acid. If manufactured in poorly controlled facilities with excessive heat or moisture, the amide group can hydrolyze, spontaneously converting the drug back into flush-inducing Nicotinic Acid. Our facilities utilize advanced, temperature-controlled dry blending and strict moisture-barrier film-coating. This guarantees 100% molecular stability, ensuring that patients receive pure Nicotinamide without suffering unexpected, severe cutaneous flushing.

Therapeutic Indications (Human Use)

Indicated for the targeted management of severe nutritional deficiencies and dermatological/oncological prophylaxis:

• Pellagra: First-line treatment and prevention of severe Vitamin B3 deficiency.
• Non-Melanoma Skin Cancer Prophylaxis: Prevention of actinic keratoses and basal/squamous cell carcinomas in high-risk patients with a history of skin cancer.
• Inflammatory Skin Diseases: Adjunctive systemic therapy for severe Acne Vulgaris, Rosacea, and autoimmune blistering diseases (like Bullous Pemphigoid, often combined with Tetracyclines).
• Osteoarthritis: Off-label use for improving joint flexibility and reducing inflammation.

Dosage & Administration

Recommended Dosage (Strictly as per Physician Guidelines):

• Pellagra: 300 mg to 500 mg daily, in divided doses, depending on severity.
• Skin Cancer Prophylaxis: 500 mg taken orally twice daily (BID).
• Administration: Can be taken with or without food. Taking with meals can drastically reduce mild gastrointestinal upset.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• The Lipid-Lowering Fallacy (CLINICAL WARNING): Physicians and patients must be explicitly warned that Nicotinamide does not lower cholesterol or triglycerides. If a patient requires lipid modification, they must be prescribed Nicotinic Acid or a Statin. Substituting Nicotinamide will leave the patient entirely unprotected from cardiovascular events.
• Hepatic Impairment: While much safer than Nicotinic Acid, extreme mega-doses of Nicotinamide (exceeding 3,000 mg/day) can still cause elevated liver enzymes and hepatotoxicity. Liver function should be monitored in patients on high-dose chronic therapy.
• Gastrointestinal Distress: High doses frequently cause nausea, vomiting, and diarrhea. Taking the medication with food mitigates this risk.
• Gallbladder Disease: Should be used with caution in patients with a history of jaundice, liver disease, or active gallbladder/biliary tract disease.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Dermatology Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Vitamin, Dermatological, and Oncology-Support Formulations. Whether you are looking for a reliable Government Tender Supplier for malnutrition clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely, secure delivery of highly stable, WHO-GMP certified products.