Description

Nelfinavir Mesylate Tablets (250 mg / 625 mg)

Healthy Inc is a specialized global supplier and exporter of HIV-1 Protease Inhibitors (PIs). We provide high-stability Nelfinavir Mesylate Tablets, sourced from WHO–GMP certified solid dosage facilities specializing in infectious disease management. This critical antiretroviral agent is a top export to HIV/AIDS clinics, specialized hospitals, and government health ministries in Africa, Southeast Asia, and LATAM, serving as a key component of highly active antiretroviral therapy (HAART).

Product Overview

This formulation contains Nelfinavir Mesylate, a potent, selective, and orally bioavailable inhibitor of the HIV-1 protease enzyme, designed to halt viral replication at the final stage of the life cycle.

The “Protease Blockade” Specialist:

• Mechanism of Action: Nelfinavir binds to the active site of the HIV-1 Protease enzyme. By doing so, it prevents the cleavage of the gag-pol polyprotein precursors into individual functional proteins necessary for the formation of infectious, mature virions. This results in the production of immature, non-infectious viral particles, effectively lowering the viral load in the blood.
• Resistance Profile: Nelfinavir has a unique resistance mutation pattern (the D30N mutation), which often preserves the efficacy of other protease inhibitors (like Lopinavir or Saquinavir) for future “second-line” rescue therapy.
• Pharmacokinetic Advantage: Unlike some other protease inhibitors, Nelfinavir does not strictly require boosting with Ritonavir to reach therapeutic levels, although it is often used in combination with other ARVs for maximum suppression.

Product Composition & Strength

We supply this product as Film Coated Tablets. Due to the high dose required for therapeutic efficacy, we ensure the tablet is engineered for ease of swallowing without compromising the structural integrity of the high-API load.

*Pack Sizes: HDPE Jars of 60s, 120s, or 270s (Bulk supply for HIV programs).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Hygroscopic Protection: Nelfinavir Mesylate is sensitive to environmental moisture. Our Automatic Bottle Filling Lines include integrated desiccant insertion and induction sealing to ensure the product remains stable through long-distance maritime transport to African and LATAM ports.
• Bioavailability Enhancement: We utilize advanced wet granulation techniques to manage the bulky nature of the Nelfinavir API, ensuring consistent disintegration times and rapid absorption in the gastrointestinal tract.

Therapeutic Indications (Human Use)

Indicated for the treatment of HIV infection as part of a combination regimen:

• HIV-1 Infection (Adults): Management of viral suppression in antiretroviral-naive or experienced patients.
• Pediatric HIV: Use in children 2 years of age and older (250mg strength is preferred for weight-based dosing).
• Post-Exposure Prophylaxis (PEP): Occasionally used in multi-drug PEP regimens following occupational or non-occupational exposure.

Dosage & Administration

Recommended Dosage (Strictly as per ID Specialist):

• Route: Oral.
• Adult Dose (Standard): 1250 mg (two 625 mg tablets or five 250 mg tablets) twice daily.
• Alternative Dose: 750 mg three times daily.
• Administration (CRITICAL): Must be taken with a meal. Food significantly increases the absorption and peak plasma concentration of Nelfinavir.

Safety Warnings:

• Drug Interactions: Nelfinavir is a substrate and inhibitor of CYP3A4. It has extensive interactions with other drugs (e.g., Rifampin, St. John’s Wort, certain Statins). Review all concurrent medications.
• Gastrointestinal Side Effects: Diarrhea is the most common side effect; often managed with over-the-counter anti-diarrheal agents.
• Metabolic Effects: Long-term use of protease inhibitors may be associated with redistribution of body fat (lipodystrophy) and increases in blood sugar or cholesterol.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.

Commercial Inquiries

For hospital tenders, bulk export, or distributor pricing, please contact our export team.

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in