Description
Metronidazole Tablet
Metronidazole Tablets BP / IP / USP (200 mg / 400 mg / 500 mg)
Healthy Life Pharma Private Limited, alongside our specialized global export division Healthy Inc, is a premier Indian manufacturer, CDMO partner, and bulk exporter of advanced anti-infective, gynecological, and gastroenterological therapeutics. We manufacture ultra-high-purity, kinetically stable Metronidazole Tablets within our WHO–GMP certified, high-capacity solid dosage manufacturing facilities. This foundational “Broad-Spectrum Nitroimidazole Antiprotozoal and Antibacterial Agent” serves as an essential strategic export to hospital procurement networks, public health ministry pipelines, state healthcare tenders, and international B2B wholesale marketplaces across Africa, the CIS region, LATAM, and Southeast Asia.
Product Overview
This formulation operates as a “Pathogen DNA Helical Disrupter.” It ensures patient safety and total microbial eradication by selectively utilizing the anaerobic metabolic pathways of specific pathogens to trigger localized cellular destruction.
Mechanism 1 (Intracellular Prodrug Activation): Metronidazole is an inactive prodrug that physically diffuses across the cell walls of anaerobic bacteria and protozoa. Once inside, it chemically interacts with the pathogen’s electron transport protein, ferredoxin.
Mechanism 2 (Free-Radical Generation): The structural nitro group of the drug is chemically reduced by the anaerobic electron transport system. This intermediate reduction process physically generates highly reactive cytotoxic nitro free radicals.
Mechanism 3 (DNA Helix Destruction): These free radicals physically bind to and chemically fracture the bacterial and protozoal DNA strands. This causes immediate strand breakage, helix destabilization, and total inhibition of nucleic acid synthesis, forcing rapid pathogen cell death. Note: Aerobic cells are physically unaffected because they lack the low-redox electron transport systems required to activate the drug.
Product Composition & Available Strengths
We supply Metronidazole in standard, internationally recognized strengths optimized for adult and pediatric treatment regimens.
| Active Ingredient | Available Strengths | Common Dosage Matrix | Primary Clinical Target |
| Metronidazole BP / IP / USP | 200 mg | Film-Coated / Uncoated Oral Tablet | Pediatric & Low-Dose Titration: For delicate adjustments in mild amoebic dysentery or combination protocols. |
| Metronidazole BP / IP / USP | 400 mg | Film-Coated / Uncoated Oral Tablet | Standard Generic Backbone: Standard twice or thrice-daily dosing for dental abscesses and Giardiasis. |
| Metronidazole BP / IP / USP | 500 mg | High-Potency Oral Tablet | Institutional Target: High-volume strength preferred for anaerobic surgical prophylaxis and severe trichomoniasis. |
Technical & Logistics Specifications
HS Code: 3004.20.99 (Medicaments containing antibiotics / Synthesized antiprotozoals)
CAS Number: 443-48-1 (Metronidazole)
Dosage Form: Oral Solid Tablet (Film-Coated to completely mask the intensely bitter chemical taste of the active ingredient)
Packaging Configurations: 10 Tablets per Blister Strip packed in high-barrier Alu-Alu (Cold-Form Foil) or thick PVC/PVDC strips, or 100 / 500 / 1000 Tablets per Bulk HDPE Bottle for institutional hospital supply. Our tropicalized packaging configurations physically seal out environmental moisture, guaranteeing a 36-month shelf life in hot, humid Zone IVb export environments.
Manufacturing Authority & Compliance
Taste-Masking Polymer Film Technology: Metronidazole raw active powder possesses an exceptionally bitter, metallic taste that can cause immediate pediatric non-compliance. Our processing suites apply an Advanced Hydroxypropyl Methylcellulose (HPMC) Taste Barrier, physically isolating the core without slowing gastrointestinal absorption kinetics.
Isolated Anti-Infective Processing Suites: To satisfy strict international B2B regulatory audits, our manufacturing facility handles anti-infective compression inside Dedicated HVAC-Isolated Air-Pressure Enclosures, completely preventing active chemical cross-contamination.
High-Volume Automated Granulation: Metronidazole is high-bulk crystalline substance. We utilize Automated High-Shear Granulators and Fluid Bed Dryers, physically ensuring perfectly uniform granular density and automated weight consistency during high-speed compression cycles.
Primary Indications
Gastroenterology: Treatment of Amoebic Liver Abscesses, Acute Amoebic Dysentery caused by Entamoeba histolytica, and Giardiasis caused by Giardia lamblia.
Anaerobic Bacterial Infections: Eradication of intra-abdominal infections, pelvic inflammatory disease, peritonitis, and deep dental abscesses caused by Bacteroides fragilis and Clostridium species.
Gynecology: Frontline clearance of Trichomoniasis vaginitis caused by Trichomonas vaginalis and bacterial vaginosis.
Surgical Prophylaxis: Routine perioperative prevention of anaerobic contamination during elective colorectal and gynecological surgical interventions.
Usage Instructions
Administration Guideline: Swallow tablets physically whole with a full glass of water with or immediately after a meal to physically minimize gastric irritation.
The Alcohol Disulfiram Prohibition: Patients must strictly avoid alcohol consumption during Metronidazole therapy and for at least 48 to 72 hours after the final dose. Metronidazole chemically inhibits hepatic aldehyde dehydrogenase, physically inducing a severe Disulfiram-like Reaction characterized by intense abdominal cramps, nausea, vomiting, facial flushing, and tachycardia.
Complete the Course Mandate: To prevent breeding global multi-drug bacterial resistance, the full course must be completed, even if symptomatic relief occurs within the first 48 hours.
Safety Warning: POTENT BROAD-SPECTRUM SYSTEMIC ANTI-INFECTIVE. For Professional Medical Supervision Only. The Disulfiram Danger: Strictly prohibit alcohol intake due to risks of severe acetaldehyde accumulation reactions. Neurological Note: High-dose or prolonged usage may physically induce peripheral neuropathy or central nervous system toxicity (dizziness, ataxia, confusion); monitor neurological status closely. Contraindication: Do not use in patients presenting with active neurological disorders, severe hepatic impairment, during the first trimester of pregnancy, or with known hypersensitivity to nitroimidazole derivatives.
Global CDMO Services & Wholesale Supply Chain
Healthy Life Pharma Private Limited and Healthy Inc provide complete, internationally validated Third-Party Contract Manufacturing (CDMO Services) and bulk private-label export pipelines for the entire Metronidazole dosage spectrum. Whether you are executing a high-volume procurement contract for an African National Health Ministry Tender, stocking state hospital networks in the CIS region, or maintaining active inventory listings on an international digital B2B Pharmaceutical Marketplace across Southeast Asia or LATAM, we deliver all required documentation (WHO-GMP Certificate, Certificates of Pharmaceutical Product – COPP, Certificates of Analysis – COA, Stability Testing Matrix Sheets, and Complete CTD Format Dossier sets) for rapid entry registration.
Commercial & Bulk Procurement Inquiries:
Corporate Head Office: Mumbai, Maharashtra, India
Primary Manufacturing Base: Boisar, Maharashtra, India
WhatsApp / Direct Call: +91 7710003340
Corporate Email: info@healthyinc.co.in
