Description
Metoclopramide Tablet
Metoclopramide Hydrochloride Tablets USP / BP / IP (10 mg)
Prokinetic Gastric Stimulant & Central Antiemetic
Healthy Life Pharma Private Limited, alongside our specialized global export and marketing division Healthy Inc, is a premier Indian manufacturer, CDMO partner, and wholesale exporter of advanced gastroenterology, internal medicine, and supportive care therapeutics. We manufacture ultra-high-purity, kinetically stable Metoclopramide Hydrochloride Tablets (10 mg) within our state-of-the-art, WHO–GMP certified solid dosage manufacturing facilities.
Serving as a foundational therapeutic for gastrointestinal motility disorders and emesis control, this product is a high-volume strategic export to hospital procurement networks, public health ministry pipelines, state healthcare tenders, and international B2B wholesale marketplaces across Africa, the CIS region, LATAM, and South-East Asia.
Product Overview
This formulation operates as a “Dual-Action Gastrointestinal Prokinetic and Emetic Blocker.” It ensures patient safety and clinical success by accelerating upper digestive tract motility while simultaneously raising the threshold of the brain’s vomiting center.
Mechanism 1 (Central Dopamine Receptor Antagonism): Metoclopramide physically crosses the blood-brain barrier and chemically binds to and blocks central Dopamine ($D_{2}$) receptors inside the Chemoreceptor Trigger Zone (CTZ). This direct central blockade prevents emetic chemicals from triggering the brain’s vomiting reflex.
Mechanism 2 (Peripheral Cholinergic Stimulation): Within the gastrointestinal tract, it physically blocks peripheral $D_{2}$ receptors and chemically enhances the tissues’ sensitivity to acetylcholine. This mechanism accelerates the upper GI tract’s muscular tone and contraction velocity.
Mechanism 3 (Accelerated Gastric Emptying): This combined action physically increases the resting tone of the lower esophageal sphincter while simultaneously relaxing the pyloric sphincter and accelerating gastric emptying and intestinal transit. This physically prevents gastric stasis (pooling) which is the primary driver of nausea, bloating, and acid reflux.
Product Composition & Packaging Specification
We supply Metoclopramide in the globally standardized therapeutic strength optimized for adult baseline three-times-daily dosage regimens.
| Active Ingredient Monograph | Calibrated Strength | Formulation Delivery Matrix | Primary Clinical Function |
| Metoclopramide Hydrochloride USP / BP / IP | 10 mg | Oral Solid Uncoated Tablet (Scored for micro-dosing titration) | The Prokinetic Driver: Accelerates upper gastrointestinal transit and blocks central emetic signals. |
| Excipients | Pharma Grade | Lactose, Starch, Magnesium Stearate | The Core Scaffold: High-solubility matrix engineered for rapid physical disintegration. |
Technical & Logistics Specifications
HS Code: 3004.90.99 (Medicaments acting on the alimentary tract / Antiemetics / Prokinetics)
CAS Number: 54143-57-6 (Metoclopramide Hydrochloride Monohydrate) / 364-62-5 (Metoclopramide Base)
Dosage Form: Oral Solid Tablet
Packaging Configurations: 10 Tablets per Blister Strip packed in high-barrier Alu-Alu (Cold-Form Foil) or light-shielded amber PVC/PVDC strips. Metoclopramide raw structures are physically sensitive to light degradation; our premium tropicalized packaging completely blocks light transit, guaranteeing a full 36-month shelf life in hot, humid Zone IVb export environments.
Advanced Manufacturing Integrity & Quality Controls
Moisture-Shield Granulation Control: Metoclopramide Hydrochloride is highly hydrophilic and prone to hydrolytic variations if handled incorrectly. We operate our complete blending, granulation, and compression lines inside Climate-Controlled Processing Blocks with strict humidity parameters (RH less than 30%), preserving molecular consistency.
High-Velocity Compression Uniformity: Because the active drug component represents a low mass (10 mg) relative to the total tablet core, we utilize Automated Multi-Stage Geometric Solid Blenders with Online Active Weight Verifiers, physically guaranteeing absolute chemical content uniformity across every batch.
Kinetic Bioavailability Verification: Every production batch physically undergoes Automated In-Vitro Dissolution Profiling, chemically validating that our generic tablets precisely replicate the rapid disintegration and absorption curves of global innovator benchmarks (such as Reglan / Maxolon).
Primary Indications
Gastroenterology: Symptomatic treatment of acute and recurrent Diabetic Gastroparesis (delayed gastric emptying) and management of severe Gastroesophageal Reflux Disease (GERD) refractory to standard proton-pump inhibitors.
Oncology Support: Prevention of nausea and vomiting associated with emetogenic chemotherapy, radiation sickness, or post-operative recovery windows.
Neurology Support: Adjuvant management of Migraine-Associated Nausea, where accelerating gastric emptying physically improves the absorption of co-administered oral pain medications.
Usage Instructions
The Pre-Meal Timing Window: To maximize prokinetic chemical efficacy, the tablet must be taken physically 30 minutes before meals and at bedtime.
The 5-Day Limitation Rule: Modern clinical guidelines recommend limiting continuous usage of Metoclopramide to a maximum duration of 5 consecutive days wherever possible, physically minimizing the risk of cumulative neurological side effects.
Avoid Central Depressants: Patients must strictly avoid co-administering alcohol, sedatives, or narcotics alongside Metoclopramide, as it chemically intensifies central nervous system depression and sedation.
Safety Warning: POTENT PROKINETIC & CENTRAL ANTIEMETIC. For Professional Medical Supervision Only. Extrapyramidal Side Effects (EPS): May centrally induce drug-related neurological movements, including acute dystonia, facial muscle spasms, or Tardive Dyskinesia (particularly in elderly or prolonged-use profiles); discontinue immediately if involuntary muscle twitches occur. Drowsiness Warning: Physically induces central sedation; advise patients against driving or operating automated industrial machinery during active management. Contraindications: Absolute contraindications in patients presenting with mechanical gastrointestinal obstruction, bowel perforation, active internal hemorrhage, pheochromocytoma (risk of hypertensive crisis), epilepsy, or known hypersensitivity to metoclopramide matrices.
Global CDMO Services & Wholesale Supply Chain
Healthy Life Pharma Private Limited and Healthy Inc provide complete, internationally validated Third-Party Contract Manufacturing (CDMO Services) and bulk private-label export pipelines for generic Metoclopramide 10 mg Tablets. Whether you are executing a high-volume procurement contract for a National Ministry of Health Tender across Sub-Saharan Africa, supplying an institutional hospital cooperative across the CIS region, or injecting high-demand inventory lines into an international digital B2B Pharmaceutical Marketplace across Southeast Asia or LATAM, we prepare all legally required registration dossiers (WHO-GMP Certificate, Certificates of Pharmaceutical Product – COPP, Certificates of Analysis – COA, Stability Matrix Data, and Complete CTD Format Dossier sets) for seamless global registration.
Commercial & Bulk Procurement Inquiries:
Corporate Head Office: Mumbai, Maharashtra, India
Primary Manufacturing Base: Boisar, Maharashtra, India
WhatsApp / Direct Call: +91 7710003340
Corporate Email: info@healthyinc.co.in
