Description

Methylprednisolone Sodium Succinate Injection

Healthy Inc is a specialized global supplier and exporter of high-potency corticosteroids. We provide high-purity Methylprednisolone Sodium Succinate Injection (40 mg / 125 mg / 500 mg / 1 gm), manufactured in WHO–GMP certified sterile lyophilization facilities. This “Immune-Modulator” is a mandatory export to trauma centers, respiratory units, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the gold standard for high-dose “Pulse Therapy” in acute spinal cord injury, severe asthma, and autoimmune crises.

Product Overview

This formulation contains Methylprednisolone Sodium Succinate, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive activity.

The “Acute Response” Specialist:

• Mechanism (Genomic Regulation): It diffuses across the cell membrane and binds to specific cytoplasmic glucocorticoid receptors. This complex enters the nucleus and binds to DNA, inhibiting the synthesis of pro-inflammatory cytokines (IL-1, IL-2, IL-6, TNF-alpha) and enzymes (COX-2) responsible for inflammation.
• High Potency: It has 5 times the anti-inflammatory potency of Hydrocortisone with minimal mineralocorticoid (salt-retaining) activity, making it safer for high-dose therapy in cardiac patients.
• Neuroprotection: In acute spinal cord injury, massive doses given within 8 hours of trauma inhibit lipid peroxidation and reduce edema, preserving nerve function.

Product Composition & Strength

We supply this product as a Sterile Lyophilized Powder requiring reconstitution with the provided solvent.

*Pack Sizes: Single Vial with Diluent.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Lyophilization Integrity: Methylprednisolone is unstable in solution. Our advanced freeze-drying process ensures a moisture content of < 1%, providing a shelf life of 36 months while maintaining rapid solubility (reconstitutes in < 30 seconds).
• Solvent Purity: For high-dose vials (500mg/1g), the provided solvent is strictly endotoxin-free to prevent “steroid flares” or pyrogenic reactions during rapid IV infusion.

Therapeutic Indications (Human Use)

Indicated for anti-inflammatory and immunosuppressive management:

• Acute Spinal Cord Injury: High-dose protocol within 8 hours of injury.
• Severe Allergic States: Anaphylaxis, Status Asthmaticus (refractory asthma).
• Autoimmune Disorders: Systemic Lupus Erythematosus (SLE), Multiple Sclerosis (Acute exacerbation).
• Organ Transplant: Prevention and treatment of acute rejection episodes.
• COVID-19 / ARDS: Management of cytokine storm and lung inflammation (Specific protocols).

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Route: Intravenous (IV) or Intramuscular (IM).
• Standard Dose: 10 mg to 40 mg IV, repeated as needed.
• Pulse Therapy (Lupus/MS): 30 mg/kg IV administered over at least 30 minutes. (Often 1 gm daily for 3 days).
• Spinal Cord Injury: Bolus of 30 mg/kg IV over 15 minutes, followed by 5.4 mg/kg/hour infusion for 23 hours.
• Rapid Injection Warning: High doses (>500 mg) must be infused over at least 30 minutes to prevent arrhythmias and circulatory collapse.

Safety Warnings (CRITICAL):

• Hyperglycemia: Causes rapid spikes in blood sugar. Monitor diabetic patients closely.
• Infection Risk: Suppresses the immune system, masking signs of infection (sepsis, TB).
• Peptic Ulcer: Increases risk of GI bleeding, especially if used with NSAIDs.
• Psychiatric Effects: Can cause euphoria, insomnia, mood swings, or psychosis (“Steroid Psychosis”).

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.