Description

Levosulpiride Tablets (25 mg / 50 mg / 75 mg)

Healthy Inc is a specialized global supplier and exporter of advanced gastroenterology, internal medicine, and psychosomatic therapeutics. We provide ultra-high-purity, kinetically optimized Levosulpiride Film-Coated / Uncoated Tablets (25 mg / 50 mg / 75 mg), manufactured in WHO–GMP certified, high-precision rapid-release oral solid dosage facilities. This “Atypical Prokinetic & Brain-Gut Axis Modulator” is a massive-volume, highly lucrative export to gastroenterology centers, specialized metabolic clinics, retail pharmacy networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, dual-action intervention for severe Functional Dyspepsia, Gastroesophageal Reflux Disease (GERD), and Diabetic Gastroparesis.

Product Overview

This highly advanced formulation fundamentally bridges the gap between the brain and the digestive tract. By selectively blocking specific dopamine receptors in both the gut and the central nervous system, it physically forces the stomach to empty while chemically suppressing the nausea and anxiety associated with chronic digestive failure.

The “Brain-Gut Axis & Prokinetic” Specialist:

• Mechanism 1 (The Peripheral Prokinetic Engine): In patients with functional dyspepsia or diabetic gastroparesis, the stomach is partially paralyzed. Food sits in the gut and rots, causing severe bloating, early satiety, and pain. Levosulpiride violently blocks D2 dopamine receptors in the gastrointestinal tract. This blockade massively increases the release of acetylcholine, forcefully stimulating the smooth muscle of the stomach and intestines to contract and physically push the food forward (gastric emptying).
• Mechanism 2 (The Central Anti-Emetic Shield): Simultaneously, Levosulpiride crosses into the brain and targets the Chemoreceptor Trigger Zone (CTZ). By blocking D2 receptors here, it acts as a highly potent anti-emetic, instantly shutting down the neurological signals that cause severe nausea and vomiting.
• Mechanism 3 (The Psychosomatic Calming Effect): Unlike older prokinetics (like Domperidone), Levosulpiride possesses mild atypical antipsychotic and anxiolytic (anti-anxiety) properties at low doses. Because severe gut issues are deeply intertwined with stress and anxiety (the Brain-Gut Axis), this unique molecule calms the central nervous system, providing profound psychological relief alongside physical digestive repair.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Gastroenterology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Rapid-Gastric Preparation Engineering (CRITICAL COMPLIANCE): The clinical success of a prokinetic is entirely dependent on its timing. If the tablet takes an hour to dissolve, the patient will have already eaten their meal, and the stomach will paralyze. Our facilities utilize advanced high-shear dry blending and elite superdisintegrants (like Crospovidone) to ensure the tablet shatters immediately upon hitting gastric fluid. This guarantees the drug is fully absorbed and the stomach is actively contracting before the patient takes their first bite of food.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly specialized management of gastrointestinal and psychosomatic disorders:

• Functional Dyspepsia: Treatment of severe, unexplained indigestion, epigastric pain, early satiety, and post-meal bloating.
• Diabetic Gastroparesis: Restoration of gastric emptying in diabetic patients suffering from severe autonomic neuropathy of the gut.
• Gastroesophageal Reflux Disease (GERD): Used as an adjunct to Proton Pump Inhibitors (PPIs) to forcefully close the lower esophageal sphincter and push stomach acid downward.
• Irritable Bowel Syndrome (IBS): Relief of overall gut dysmotility and associated psychosomatic stress.

Dosage & Administration

Recommended Dosage (Strictly as per Gastroenterologist Guidelines):

• Standard Adult Dosing (Dyspepsia/Prokinetic): 25 mg taken orally three times a day.
• The “Pre-Meal” Rule (CRITICAL CLINICAL DIRECTIVE): The tablet MUST be taken exactly 15 to 30 minutes before meals. Taking it after eating renders the prokinetic effect clinically useless.
• Duration: Typically prescribed for 4 to 8 weeks depending on the severity of the dysmotility.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Hyperprolactinemia (The Hormonal Shift): By blocking dopamine in the pituitary gland, Levosulpiride removes the “brakes” on prolactin production. Chronic use frequently causes galactorrhea (spontaneous milk discharge from the breasts), breast enlargement (gynecomastia in men), and amenorrhea (missed periods). Therapy should be halted if severe hormonal side effects occur.
• Extrapyramidal Symptoms (EPS): While much lower risk than standard antipsychotics, Levosulpiride can cross the blood-brain barrier and cause Parkinson-like tremors, muscle stiffness, and involuntary facial movements, particularly in the elderly or at high doses.
• GI Perforation/Obstruction (Absolute Contraindication): FATAL WARNING: Levosulpiride is strictly contraindicated if the patient has a suspected gastrointestinal hemorrhage, mechanical bowel obstruction, or active gastrointestinal perforation. Forcefully stimulating a blocked or bleeding bowel will cause catastrophic rupture and fatal sepsis.
• Sedation & Somnolence: Can cause moderate drowsiness; patients should avoid driving or operating heavy machinery until they know how the drug affects them.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Gastroenterology Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Gastrointestinal, Prokinetic, and Psychosomatic Formulations. Whether you are looking for a reliable Government Tender Supplier for metabolic clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.