Description

Lansoprazole (EC) & Domperidone (SR) Capsules

Healthy Inc is a specialized global supplier and exporter of advanced gastrointestinal, anti-emetic, and anti-reflux therapeutics. We provide high-purity Lansoprazole (30 mg Enteric-Coated) & Domperidone (30 mg Sustained-Release) Capsules, manufactured in WHO–GMP certified, advanced multi-particulate pelletization facilities. This “Rapid-Onset Anti-Reflux & Anti-Emetic Synergy” is a massive-volume, premium export to gastroenterology centers, primary care networks, and government health ministries in Africa, LATAM, the Middle East, and Southeast Asia, serving as the definitive intervention for acute Gastroesophageal Reflux Disease (GERD) flares and severe functional dyspepsia.

Product Overview

This advanced formulation combines two highly synergistic gastrointestinal agents: Lansoprazole (a highly potent, fast-acting Proton Pump Inhibitor) and Domperidone (a peripheral dopamine D2 receptor antagonist with potent anti-emetic properties).

The “Rapid Relief & Nausea Control” Specialist:

• Mechanism 1 (Lansoprazole – Rapid Acid Suppression): Lansoprazole travels to the highly acidic secretory canaliculi of the gastric parietal cells, where it covalently and irreversibly binds to the H+/K+ ATPase enzyme system (the proton pump). It completely shuts down gastric acid secretion. Clinically, Lansoprazole is highly favored for providing remarkably fast relief of daytime and nighttime heartburn, often outpacing older PPIs in the first 48 hours of therapy.
• Mechanism 2 (Domperidone – Peripheral Motility & Anti-Emesis): Acid suppression alone cannot fix a sluggish stomach. Domperidone actively blocks Dopamine D2 receptors in the upper gastrointestinal tract, physically tightening the lower esophageal sphincter (LES) to stop regurgitation and accelerating gastric emptying. Crucially, it blocks D2 receptors in the Chemoreceptor Trigger Zone (CTZ) located just outside the blood-brain barrier, acting as an incredibly powerful anti-emetic to stop acid-induced nausea.
• The “Brain-Safe” Prokinetic Advantage: Unlike older motility agents like Metoclopramide, Domperidone does not cross the blood-brain barrier. This eliminates the risk of devastating central nervous system side effects (Extrapyramidal Symptoms or severe tremors), making it exceptionally safe for daily prescribing.
• The Sustained-Release Advantage: Standard Domperidone wears off in a few hours. By utilizing a Sustained-Release (SR) formulation, this single daily capsule provides continuous 24-hour motility and nausea suppression synchronized flawlessly with the 24-hour acid blockade of Lansoprazole.

Product Composition & Strength

We supply this product as a highly advanced Hard Gelatin Capsule containing Dual-Isolated Pellets, packed strictly in high-barrier Alu-Alu blister strips.

*Pack Sizes: 10×10 Alu-Alu Blisters (optimizing for 30-day monthly gastroenterology dispensing cycles).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Gastroenterology Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Dual-Kinetic Pelletization Engineering: Lansoprazole is an acid-labile drug that is instantly destroyed by gastric acid. Our specialized fluid-bed coating machinery applies a rigorous methacrylic acid enteric-coating to the Lansoprazole pellets, ensuring they pass through the stomach completely intact. Simultaneously, the Domperidone is coated in a specialized sustained-release hypromellose matrix. This advanced capsule-in-capsule technology guarantees two completely different pharmacokinetic release profiles flawlessly synchronized for a 24-hour therapeutic window.
• Assay Validation: Rigorous multi-stage dissolution testing (in both acidic and buffer mediums) is performed via HPLC on every batch to guarantee the physical integrity of the enteric coating and the slow-release matrix, preventing Domperidone dose-dumping.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of high-volume gastrointestinal motility and acid disorders:

• Gastroesophageal Reflux Disease (GERD): Treatment of erosive or ulcerative GERD that is unresponsive to PPI monotherapy, especially when accompanied by severe regurgitation or delayed gastric emptying.
• Functional Dyspepsia: Management of chronic upper abdominal pain, post-prandial fullness, severe bloating, and early satiety.
• Acute Nausea & Vomiting: Highly effective in managing acid-peptic induced nausea or vomiting associated with acute GERD flares.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Administration (TIMING IS CRITICAL): Must be taken orally, once daily, approximately 30 to 60 minutes BEFORE breakfast. The Lansoprazole must be absorbed and present in the bloodstream when the parietal cells are stimulated to secrete acid by the first meal of the day.
• Swallowing Protocol (CRITICAL): The capsule MUST be swallowed whole. It must not be crushed, chewed, or opened. Destroying the capsule compromises both the enteric coating and the SR matrix.

Safety Warnings (CRITICAL):

• Cardiac Risk (QT Prolongation): Domperidone has been associated with a small increased risk of QT interval prolongation and serious ventricular arrhythmias. It should be used with caution in older patients, those with underlying cardiac disease, or those concurrently taking potent CYP3A4 inhibitors.
• Clostridioides difficile-Associated Diarrhea: Profound, long-term acid suppression significantly increases the risk of severe intestinal infections.
• Hypomagnesemia: Long-term use of Lansoprazole (over 1 year) is associated with severe drops in blood magnesium levels, which can further exacerbate cardiac arrhythmias.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Gastroenterology Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in LATAM or a B2B Pharma Marketplace partner for Africa, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.