Description

Isoxsuprine Hydrochloride Tablets (10 mg IR / 40 mg SR)

Healthy Inc is a specialized global supplier and exporter of advanced obstetrics, gynecology, and peripheral vascular therapeutics. We provide ultra-high-purity, kinetically precise Isoxsuprine Hydrochloride Immediate-Release (10 mg) and Sustained-Release (40 mg) Tablets, manufactured in WHO–GMP certified, high-precision modified-release oral solid dosage facilities. This “Beta-Adrenergic Agonist & Tocolytic” is a massive-volume, highly critical export to maternity hospitals, obstetrics networks, geriatric vascular centers, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as a life-saving intervention to halt premature labor and a foundational therapy for severe peripheral vascular diseases.

Product Overview

This highly advanced formulation acts as a targeted smooth-muscle relaxant. By chemically binding to specific receptors in the body, it forces violently contracting muscle tissue to relax, effectively stopping premature birth in the uterus and opening up choked blood vessels in the extremities.

The “Uterine Relaxant & Vasodilator” Specialist:

• Mechanism 1 (The Tocolytic Uterine Blockade): During premature labor, the smooth muscles of the uterus begin to violently rhythmically contract. Isoxsuprine is a beta-adrenergic receptor agonist. It aggressively stimulates the beta-receptors lining the uterine wall, which massively increases intracellular cAMP. This chemical cascade physically paralyzes the uterine muscle, halting the contractions and preventing the premature expulsion of the fetus.
• Mechanism 2 (Peripheral Vasodilation): In conditions like arteriosclerosis, Raynaud’s phenomenon, or Buerger’s disease, the blood vessels in the hands and feet become tightly constricted, causing severe pain and tissue death. Isoxsuprine’s beta-agonist properties directly relax the smooth muscle lining the arterial walls. This forces the blood vessels to dilate (widen), instantly restoring rich, oxygenated blood flow to the starving extremities.
• The SR Matrix Advantage: Beta-agonists inherently stimulate the heart. To prevent dangerous maternal tachycardia (rapid heart rate), our 40mg Sustained-Release (SR) formulation slowly trickles the drug into the bloodstream over 12 hours. This flattens the pharmacokinetic curve, providing constant uterine relaxation without the sudden, toxic cardiovascular spikes seen in cheap generic formulations.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Obstetrics Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Sustained-Release (SR) Polymer Engineering (CRITICAL COMPLIANCE): The greatest risk of oral beta-agonists in pregnancy is dose-dumping, which can trigger acute maternal hypotension and fetal distress. Our facilities utilize advanced wet-granulation and elite hydrophilic polymer matrices (HPMC) to ensure a flawless, 12-hour linear release profile. This highly regulated manufacturing standard guarantees that the mother receives continuous uterine relaxation while completely shielding her heart from toxic plasma spikes.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly specialized management of obstetrical emergencies and vascular insufficiency:

• Premature Labor (Tocolysis): Arrest of premature uterine contractions to delay delivery, allowing time for the administration of maternal corticosteroids to accelerate fetal lung maturity.
• Peripheral Vascular Disease: Relief of symptoms associated with arteriosclerosis obliterans, Buerger’s disease (thromboangiitis obliterans), and Raynaud’s disease.
• Cerebrovascular Insufficiency: Adjunctive therapy to improve blood flow to the brain in geriatric patients.

Dosage & Administration

Recommended Dosage (Strictly as per Obstetrician/Physician Guidelines):

• Premature Labor (Oral Maintenance): Following successful intravenous/intramuscular arrest of labor, oral maintenance is typically initiated at 10 mg three to four times daily (IR) or 40 mg once to twice daily (SR).
• Vascular Disorders: Typically 10 mg to 20 mg three to four times daily.
• Administration: Can be taken with or without food. SR tablets MUST be swallowed whole and never crushed or chewed.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Maternal Tachycardia & Hypotension: As a beta-agonist, Isoxsuprine will increase maternal and fetal heart rates while dropping maternal blood pressure. Vitals must be strictly monitored during therapy.
• Maternal Pulmonary Edema (FATAL WARNING): Especially when used with IV fluids or corticosteroids, beta-agonists carry a severe, life-threatening risk of fluid flooding the mother’s lungs (pulmonary edema). Therapy must be halted immediately if the mother experiences shortness of breath or chest tightness.
• Arterial Bleeding Contraindication: Because it is a powerful vasodilator, Isoxsuprine is strictly contraindicated in patients who have recently given birth (immediate postpartum) or who have any active arterial bleeding, as it will massively accelerate blood loss.
• Cardiac Disease: Strictly contraindicated in patients with known severe ischemic heart disease or preexisting severe tachycardia.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Obstetrics Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Tocolytics, Vasodilators, and Sustained-Release Formulations. Whether you are looking for a reliable Government Tender Supplier for maternity hospitals in Africa or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.