Description

Indomethacin Capsules

Healthy Inc is a specialized global supplier and exporter of advanced orthopedic, rheumatological, and acute pain-management therapeutics. We provide high-purity Indomethacin Capsules (25 mg / 50 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “High-Potency Non-Selective NSAID” is a massive-volume, priority export to rheumatology centers, orthopedic hospitals, sports medicine clinics, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the definitive, globally trusted intervention for acute gouty arthritis, ankylosing spondylitis, and severe osteoarthritis.

Product Overview

This formulation contains Indomethacin, a highly potent indole-acetic acid derivative and one of the most powerful nonsteroidal anti-inflammatory drugs (NSAIDs) available in clinical practice.

The “Heavy Artillery” Anti-Inflammatory Specialist:

• Mechanism (Profound COX Inhibition): Indomethacin aggressively and non-selectively binds to and blocks both the Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) enzymes. This completely shuts down the arachidonic acid cascade, preventing the synthesis of prostaglandins, prostacyclins, and thromboxanes. This profound reduction in prostaglandins instantly halts severe vasodilation, tissue swelling, and pain receptor sensitization at the site of joint inflammation.
• The Acute Gout Gold Standard: When uric acid crystals precipitate in a joint (gout), they cause agonizing, disabling pain. While other NSAIDs may take days to fully suppress the flare, Indomethacin’s intense potency provides rapid, dramatic relief, making it the globally preferred first-line treatment for acute gout attacks.
• Ankylosing Spondylitis Efficacy: For patients suffering from severe inflammatory arthritis of the spine (ankylosing spondylitis), Indomethacin is historically proven to provide superior symptomatic relief and stiffness reduction compared to many other modern NSAIDs.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in highly secure, moisture-resistant Alu-PVC or opaque Alu-Alu blister strips to ensure API stability across diverse climates.

*Pack Sizes: 10×10 Alu-PVC or Alu-Alu Blisters (Optimized for both short-term acute flare management and long-term rheumatology dispensing).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Rheumatology Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• API Purity & Rapid Dispersion: Because Indomethacin is frequently deployed for agonizing, acute pain, it must be rapidly absorbed in the GI tract to achieve high peak serum concentrations quickly. Our encapsulation process utilizes premium superdisintegrants to ensure the capsule ruptures immediately in the stomach, providing extremely rapid onset of action.
• Gastric Irritant Handling: Because raw Indomethacin is highly irritating to gastric mucosa, our blending parameters ensure smooth, uniform particle distribution within the excipient matrix to prevent localized “dumping” and minimize immediate stomach lining irritation.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of severe inflammatory and arthritic disorders:

• Acute Gouty Arthritis: Rapid suppression of intense pain, swelling, and severe inflammation during acute gout attacks.
• Ankylosing Spondylitis: Management of chronic spinal inflammation and prevention of joint stiffness.
• Rheumatoid Arthritis (RA) & Osteoarthritis (OA): Relief of moderate to severe joint pain, tenderness, and swelling when standard, less potent NSAIDs have failed.
• Acute Painful Shoulder: Treatment of bursitis and tendinitis.

Dosage & Administration

Recommended Dosage (Strictly as per Rheumatologist/Physician):

• Administration (CRITICAL GASTROINTESTINAL RULE): Indomethacin is highly destructive to the stomach lining. It MUST be taken immediately after meals, with food, or with antacids to reduce severe gastrointestinal irritation.
• Acute Gout Dosing: Typically initiated at 50 mg three times a day until pain is tolerable, then rapidly tapered off.
• Swallowing Protocol: Must be swallowed whole with a full glass of water.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING (Cardiovascular Risk): Like all NSAIDs, Indomethacin carries a severe risk of triggering potentially fatal cardiovascular thrombotic events, myocardial infarction (heart attacks), and stroke, especially with prolonged use or in patients with existing cardiovascular disease. It is strictly contraindicated in the setting of coronary artery bypass graft (CABG) surgery.
• BLACK BOX WARNING (Gastrointestinal Risk): Indomethacin is infamous for causing severe, potentially fatal gastrointestinal bleeding, ulceration, and perforation of the stomach or intestines. This can occur at any time during use and without warning symptoms. Elderly patients are at much higher risk.
• Central Nervous System Effects (The “Indomethacin Headache”): Unique among NSAIDs, Indomethacin frequently causes severe frontal headaches, profound dizziness, and confusion, particularly in the morning. If severe headaches persist, the dose must be reduced or the drug discontinued.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Rheumatology Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for orthopedic programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.