Description

Flunarizine (as Dihydrochloride) Tablets (5 mg / 10 mg)

Healthy Inc is a specialized global supplier and exporter of advanced neurology, neuro-otology, and targeted cranial-vascular therapeutics. We provide ultra-high-purity, kinetically precise Flunarizine Dihydrochloride Uncoated / Film-Coated Tablets (5 mg / 10 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Selective Selective Calcium Channel Blocker & Vestibular Depressant” is a massive-volume, highly lucrative export to neurology centers, ENT (Ear, Nose, Throat) hospitals, specialized migraine clinics, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, foundational intervention for severe Migraine Prophylaxis and chronic Vestibular Vertigo.

Product Overview

This highly advanced formulation operates as a specialized physiological “shock absorber” for the brain and inner ear. It physically prevents the microscopic blood vessels in the brain from violently spasming (which causes migraines) and chemically numbs the hyperactive balance centers in the ear that cause debilitating dizziness.

The “Cranial Vasospasm Shield & Vestibular Calmer” Specialist:

• Mechanism 1 (The Cranial Calcium Blockade – Migraine): Migraines are frequently triggered by “cellular hypoxia” and subsequent violent vasospasms (constriction and massive dilation) of the cranial arteries. Flunarizine selectively blocks the influx of extracellular calcium into the smooth muscle cells lining these cerebral blood vessels. By depriving the muscle of calcium, it physically prevents the vessels from violently constricting, stopping the migraine aura and pain before it can even begin.
• Mechanism 2 (The Vestibular Depressant – Vertigo): In conditions like Ménière’s disease or vestibular neuronitis, the inner ear sends chaotic, hyperactive balance signals to the brain, causing severe, room-spinning vertigo. Flunarizine decreases the excitability of the vestibular labyrinth and simultaneously reduces the viscosity of the blood, dramatically improving microcirculation to the inner ear and instantly dampening the dizzy spells.
• Mechanism 3 (The Anti-Dopaminergic & Antihistamine Paradox): Flunarizine is not a pure calcium channel blocker; it crosses the blood-brain barrier and exhibits significant antihistamine (H1) and anti-dopaminergic activity. This provides excellent sedation for highly anxious migraine patients but creates severe clinical risks (weight gain and depression) that dictate strict dosing limits.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Neurology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Lipophilic API Control & Microdose Uniformity (CRITICAL COMPLIANCE): Flunarizine is a highly lipophilic (fat-loving) molecule. Once ingested, it stores itself in the patient’s fat tissues and has an exceptionally long elimination half-life (up to 18 days). If a tablet has poor Content Uniformity and delivers too much API, the drug will rapidly accumulate to toxic levels in the brain. Our neurology suites utilize intensive dry-blending, precise granulation, and rigorous HPLC batch-testing to guarantee 100% uniformity. This proves to major hospital boards that our dosing is clinically flawless and safe for long-term prophylaxis.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly specialized management of severe neurological and vestibular disorders:

• Migraine Prophylaxis: The prevention of frequent, severe migraine attacks (with or without aura) in patients who suffer from multiple debilitating episodes per month. (Note: It is useless for terminating an acute migraine that has already started).
• Vestibular Vertigo: Symptomatic treatment of severe vestibular vertigo, dizziness, and tinnitus associated with diagnosed inner ear disorders (e.g., Ménière’s disease).

Dosage & Administration

Recommended Dosage (Strictly as per Neurologist Guidelines):

• Standard Adult Dosing: 10 mg daily for adults (5 mg daily for patients > 65 years old).
• The Nighttime Protocol (CRITICAL): The dose MUST be given at night before bedtime. Flunarizine is highly sedating; taking it in the morning will cause severe daytime somnolence and lethargy.
• The “Drug Holiday” Mandate: Because the drug accumulates in fat tissue, continuous therapy often leads to diminishing returns and high toxicity. Neurologists frequently mandate a “drug holiday” (e.g., 2 consecutive days off per week) to allow the body to clear the excess medication.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Extrapyramidal Symptoms (EPS) & Parkinsonism: Because Flunarizine blocks dopamine, chronic use can trigger severe, drug-induced Parkinsonism (tremors, muscle rigidity, slowed movement, masked facies), particularly in the elderly. Therapy must be halted immediately if tremors develop.
• Severe Clinical Depression (BLACK BOX EQUIVALENT): The drug can trigger profound, severe depressive episodes, including suicidal ideation. It is strictly contraindicated in patients with a history of depressive illness.
• Massive Weight Gain: Flunarizine alters metabolism and stimulates appetite. Patients frequently experience rapid, significant weight gain, which is a primary reason for treatment discontinuation.
• Epilepsy Contraindication: Flunarizine can lower the seizure threshold in some patients and should be used with extreme caution or avoided in patients with a history of epilepsy.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Neurology/ENT Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Migraine Prophylactics, Vestibular Depressants, and Microdose Content-Uniformity Assured Formulations. Whether you are looking for a reliable Government Tender Supplier for headache clinics in the CIS or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.