Description

Ethamsylate Film-Coated Tablets (250 mg / 500 mg)

Healthy Inc is a specialized global supplier and exporter of advanced gynecology, surgical hemostatic, and targeted vascular therapeutics. We provide ultra-high-purity, kinetically stabilized Ethamsylate Film-Coated Tablets (250 mg / 500 mg), manufactured in WHO–GMP certified, strictly humidity-controlled and antioxidant-shielded oral solid dosage facilities. This “Primary Hemostatic & Capillary Protectant” is a massive-volume, highly critical export to maternity hospitals, ENT surgical networks, trauma centers, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, first-line intervention for severe dysfunctional uterine bleeding (menorrhagia) and surgical capillary hemorrhages.

Product Overview

This highly advanced formulation operates as a rapid-response vascular sealant. It does not artificially force the blood to clot; rather, it structurally reinforces the damaged blood vessels and supercharges the body’s natural “first responders” (the platelets) to instantly plug microscopic leaks.

The “Platelet Aggregator & Endothelial Restorer” Specialist:

• Mechanism 1 (Primary Hemostasis & Platelet Adhesion): When tiny blood vessels (capillaries) are damaged during surgery or menstruation, Ethamsylate aggressively stimulates the first step of bleeding control. It massive increases the expression of P-selectin and promotes the rapid adhesion of circulating platelets to the damaged endothelial lining. These platelets clump together rapidly, forming a highly effective physical plug to stop the micro-hemorrhage.
• Mechanism 2 (Capillary Wall Resistance): Ethamsylate acts as an anti-hyaluronidase agent. It prevents the breakdown of hyaluronic acid in the basement membrane of the capillaries. This physically thickens and reinforces the fragile blood vessel walls, drastically reducing capillary permeability and preventing blood from “seeping” into surrounding tissues.
• The “Non-Thrombogenic” Paradox: Unlike Tranexamic Acid (which stops the breakdown of clots), Ethamsylate has absolutely no effect on the plasma coagulation cascade (fibrinolysis). It does not cause vasoconstriction and does not artificially thicken the blood. This makes it exceptionally safe for elderly or high-risk patients, as it halts bleeding without triggering dangerous systemic blood clots (like DVT or pulmonary embolism).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Surgical Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Oxidation Defense & Macrodose Compression (CRITICAL COMPLIANCE): Ethamsylate is incredibly fragile when exposed to humidity. A compromised blister pack will cause the tablet to rapidly oxidize into a dark, toxic paste. Our hemostatic suites utilize strict dehumidification (RH < 30%), antioxidant blending (like Sodium Metabisulfite), and high-speed rotary presses to forge a rock-solid 500mg core. We seal it immediately with a heavy, opaque polymeric film, guaranteeing total clinical potency and flawless white/color-coated presentation for hospital buyers.

Therapeutic Indications (Human Use)

Indicated for the targeted, highly specialized management of severe capillary hemorrhages:

• Gynecology: Prevention and treatment of severe dysfunctional uterine bleeding (menorrhagia) and primary menorrhagia, significantly reducing menstrual blood loss.
• Surgery & Trauma: Prophylaxis and treatment of capillary oozing during and after delicate surgeries, particularly in highly vascularized areas (ENT, Urology, Gynecology, Dentistry).
• Internal Medicine: Management of epistaxis (severe nosebleeds), hematuria, and secondary bleeding from capillary fragility.

Dosage & Administration

Recommended Dosage (Strictly as per Gynecologist / Surgeon Guidelines):

• Menorrhagia: 500 mg taken orally 3 to 4 times a day, starting 5 days before the expected onset of menstruation and continuing for 10 days total.
• Post-Surgical Bleeding: 250 mg to 500 mg taken every 4 to 6 hours as long as the bleeding risk persists.
• Administration: Must be taken with meals to minimize severe gastrointestinal irritation.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Acute Porphyria Contraindication: Ethamsylate is strictly contraindicated in patients with a history of acute porphyria, as it can dangerously exacerbate the condition.
• Sulfite Hypersensitivity (Anaphylaxis Risk): The formulation frequently contains sulfites as an antioxidant to prevent API degradation. Patients with severe asthma or sulfite allergies may experience catastrophic anaphylactic reactions or life-threatening asthmatic episodes.
• The Arterial Bleeding Limitation: Surgeons must be aware that Ethamsylate works only on capillary beds. It is completely useless for treating massive arterial bleeds or hemorrhages originating from large severed veins.
• Fever Alert: If a patient develops a sudden, unexplained fever while taking this drug, it is a sign of a severe hypersensitivity reaction, and the therapy must be permanently halted.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving international Pharma Traders, Wholesalers, and Gynecology/Surgery Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Hemostatics, Coagulants, and Oxidation-Resistant Tableting Formulations. Whether you are looking for a reliable Government Tender Supplier for maternity hospitals in the CIS or a B2B Pharma Marketplace partner for Latin America, our highly regulated logistics network ensures timely, secure delivery of WHO-GMP certified products.