Description

Diethylcarbamazine Citrate Tablets

Healthy Inc is a specialized global supplier and exporter of essential anti-parasitic agents. We provide high-purity Diethylcarbamazine Citrate (DEC) Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Filaricidal Standard” is a top export to National Vector Borne Disease Control Programs, WHO Mass Drug Administration (MDA) initiatives, and NGO supply chains in Africa, LATAM, and Southeast Asia, serving as the cornerstone therapy for the elimination of Lymphatic Filariasis (Elephantiasis).

Product Overview

This formulation contains Diethylcarbamazine Citrate, a piperazine derivative used for over 50 years as the drug of choice for filarial infections.

The “Microfilariae Hunter” Specialist:

• Mechanism (Immune Sensitization): Unlike many anthelmintics that directly poison the worm, DEC works by altering the surface membrane of the microfilariae (larvae). This “unmasks” them, making them visible and susceptible to the host’s immune system, leading to rapid phagocytosis and destruction by white blood cells.
• Muscular Action: It also causes hyperpolarization of the worm’s muscle cells, leading to immobilization.
• Dual Action: It is highly effective against the microfilariae (larvae) of Wuchereria bancrofti and Brugia malayi, and also has a significant macrofilaricidal (adult worm killing) effect at high doses.
• TPE Specialist: It is the specific cure for Tropical Pulmonary Eosinophilia (TPE), a condition caused by a hypersensitive reaction to filarial worms in the lungs.

Product Composition & Strength

We supply this product as Uncoated Tablets (White, circular). The formulation is designed for rapid disintegration to support mass dosing campaigns.

*Pack Sizes: Blister packs of 10s (Box of 10×10), 30s, or Bulk HDPE Jars of 1000s (Program/Tender Packs).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Hygroscopicity Control: Diethylcarbamazine Citrate absorbs moisture from the air very easily. If not manufactured in controlled humidity (<45% RH) suites, the tablets can become soft and sticky. We use specialized moisture-protective packaging to ensure stability in tropical climates.
• Dissolution Profile: For Mass Drug Administration (MDA), rapid systemic absorption is key. Our tablets are engineered to release >90% of the drug within 15 minutes.

Therapeutic Indications (Human Use)

Indicated for the treatment of filarial diseases:

• Lymphatic Filariasis: Caused by Wuchereria bancrofti, Brugia malayi, or Brugia timori.
• Tropical Pulmonary Eosinophilia (TPE): An asthmatic-like condition caused by filaria.
• Loiasis: Infection with Loa loa (African Eye Worm).
• Mass Drug Administration (MDA): Often co-administered with Albendazole for the global elimination of filariasis.

Dosage & Administration

Recommended Dosage (Strictly as per Physician/Program Guidelines):

• Route: Oral.
• Lymphatic Filariasis: 6 mg/kg body weight daily in divided doses for 12 days.
• Tropical Pulmonary Eosinophilia: 6 mg/kg body weight daily in divided doses for 21 days.
• Loiasis: Requires careful titration to avoid severe reactions.
  • Day 1: 50 mg.
  • Day 2: 50 mg three times daily.
  • Day 3: 100 mg three times daily.
  • Day 4–21: 3 mg/kg three times daily (approx 9 mg/kg/day).
• Administration: Best taken after meals to reduce gastric irritation.

Safety Warnings:

• Mazzotti Reaction (Systemic): The rapid death of microfilariae can cause a severe allergic-like reaction (fever, headache, muscle pain, rash, swollen lymph nodes). This is a sign the drug is working but can be distressing. Antihistamines or corticosteroids may be needed.
• Onchocerciasis (River Blindness) – CONTRAINDICATED: DEC should NOT be used for Onchocerca volvulus infections as it can cause a severe reaction leading to permanent blindness. Ivermectin is the drug of choice there.
• Renal Impairment: Dosage reduction required as the drug is excreted by the kidneys.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.

Commercial Inquiries

For hospital tenders, bulk export, or distributor pricing, please contact our export team.

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in