Cinnarizine & Dimenhydrinate Tablets

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Product Composition & Strength

We supply this product as a Precision-Blended, Immediate-Release Tablet, packed exclusively in secure, moisture-resistant Alu-PVC or Alu-Alu blister strips to ensure the absolute chemical stability of the active antihistamine salts.

Active IngredientStrengthPrimary Clinical Function
Cinnarizine BP/USP20 mgThe Peripheral Stabilizer: Stops the influx of calcium into the inner ear hair cells to dampen the physical sensation of vertigo.
Dimenhydrinate BP/USP40 mgThe Central Antiemetic: Blocks H1 and muscarinic receptors in the brain to prevent nausea and motion-induced vomiting.
ExcipientsMicrocrystalline Cellulose / Maize Starch / Talc / Magnesium Stearate / Croscarmellose SodiumDiluent / Binder / Glidant / Superdisintegrant (Engineered specifically utilizing High-Shear Dry Blending to ensure 100% uniformity of the active APIs, providing a rapid disintegration profile that delivers relief within 30 minutes of ingestion).

*Pack Sizes: 10×10 Blisters (Optimized specifically for short-course acute vertigo regimens).

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Description

Cinnarizine & Dimenhydrinate Tablets (20 mg / 40 mg)

Healthy Inc is a specialized global supplier and exporter of advanced neurology, ENT, and targeted vestibular therapeutics. We provide ultra-high-purity, kinetically optimized Cinnarizine & Dimenhydrinate Tablets (20 mg / 40 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Calcium Channel Blocker & H1-Antagonist FDC” is a massive-volume, highly strategic export to ENT clinics, neurology networks, geriatric care centers, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally preferred intervention for severe Vertigo, Meniere’s Disease, and Motion Sickness.


Product Overview

This formulation operates as a dual-front biochemical shield against equilibrium disorders. By combining a peripheral calcium antagonist with a central antimuscarinic agent, it provides a “Complete Vestibular Shutdown,” stopping the sensation of spinning while simultaneously neutralizing the urge to vomit.

The “Dual-Pathway Equilibrium” Specialist:

  • Mechanism 1 (Peripheral Vestibular Suppression – Cinnarizine): Cinnarizine is a selective L-type calcium channel blocker. It specifically inhibits the entry of calcium into the vestibular sensory cells of the inner ear. This “calms” the hyperactive signals sent from the ear to the brain, physically reducing the intensity of the spinning sensation (Vertigo).
  • Mechanism 2 (Central Vomiting Blockade – Dimenhydrinate): Dimenhydrinate is a potent H1-receptor antagonist with significant antimuscarinic activity. It acts directly on the Chemoreceptor Trigger Zone (CTZ) and the vomiting center in the brain. This violently suppresses the nausea, vomiting, and cold sweats that accompany vestibular crises.
  • Mechanism 3 (The Synergistic Flat-Curve): Combining these two agents allows for lower individual doses of each, providing a vastly superior safety profile. The result is a rapid-acting tablet that provides 24-hour stability for patients who cannot perform daily tasks due to chronic balance disorders.

Technical & Logistics Specifications

HS Code3004.90.99 (Medicaments containing other active substances – ENT/Neurology)
CAS Numbers298-57-7 (Cinnarizine) / 523-87-5 (Dimenhydrinate)
Dosage FormUncoated or Film-Coated Tablet (Immediate Gastric Release)
PackagingAlu-PVC or Alu-Alu Blisters. Ensures physical integrity and protects the formulation from environmental humidity across Zone IVb tropical climates.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

  • Content Uniformity & Rapid Disintegration (CRITICAL COMPLIANCE): Vertigo is an acute, distressing condition. If a generic tablet shatters slowly in the stomach, the patient continues to vomit, leading to therapeutic failure. Our ENT suites utilize advanced rotary compression and super-disintegrants to guarantee a 15-minute disintegration profile. We provide global buyers with a product that delivers fast, predictable clinical rescue for acute vestibular trauma.

Therapeutic Indications

  • Vertigo: Treatment of vertigo of various origins (Meniere’s disease, vestibular neuritis, labyrinthitis).
  • Motion Sickness: Prevention and treatment of nausea and vomiting associated with travel.
  • Nausea/Vomiting: Symptomatic relief of central or peripheral emesis.

Dosage & Administration

  • Standard Adult Dosing: 1 tablet taken three times daily (TID) with or after meals.
  • The Short-Term Protocol: Generally not recommended for use beyond 4 weeks unless supervised by a neurologist, to prevent the masking of underlying brain pathologies.

Safety Warnings (CRITICAL):

  • CNS Depression (Sedation): Both agents cause profound drowsiness. Patients must not drive or operate heavy machinery. Alcohol will violently exacerbate this effect.
  • Anticholinergic Toxicity: Dimenhydrinate can cause dry mouth, blurred vision, and urinary retention. Strictly contraindicated in patients with Narrow-Angle Glaucoma or Prostate Hypertrophy (BPH).
  • Parkinson’s Disease Alert: Cinnarizine can exacerbate tremors or trigger drug-induced Parkinsonism in the elderly. Use with extreme caution in geriatric populations.

Global Export & Contract Manufacturing Services

Healthy Inc is a premier Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for ENT and Neurology FDCs. Whether you are a Government Tender Supplier for primary care in Africa or a B2B Pharma Marketplace partner in Latin America, we ensure secure, WHO-GMP compliant delivery.

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