Description

Chlorpromazine Hydrochloride & Trihexyphenidyl Hydrochloride Tablets

Healthy Inc is a specialized global supplier and exporter of advanced psychiatry, neuro-pharmacology, and targeted institutional mental health therapeutics. We provide ultra-high-purity, kinetically balanced Chlorpromazine & Trihexyphenidyl Tablets, manufactured in WHO–GMP certified, high-containment oral solid dosage facilities. This “Antipsychotic & Anticholinergic FDC” is a massive-volume, highly strategic export to psychiatric hospitals, state-run asylums, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, foundational intervention for Chronic Schizophrenia and severe psychotic agitation.

Product Overview

This formulation operates as a sophisticated, dual-front neurological stabilizer. It aggressively silences the “chemical noise” of psychosis while simultaneously deploying a secondary agent to protect the patient’s motor functions from the side effects of the primary treatment.

The “Dopamine-Acetylcholine Balance” Specialist:

• Mechanism 1 (The D2 Receptor Blockade – Chlorpromazine): Chlorpromazine is a potent, first-generation phenothiazine antipsychotic. It violently binds to and blocks post-synaptic Dopamine D2 receptors in the mesolimbic pathway of the brain. This instantly shuts down the hallucinations, delusions, and aggressive agitation associated with schizophrenia.
• Mechanism 2 (The EPS Prevention – Trihexyphenidyl): When dopamine is blocked in the motor pathways (nigrostriatal), the level of acetylcholine becomes relatively too high, causing violent muscle tremors and rigidity (EPS). Trihexyphenidyl is a centrally acting antimuscarinic agent. It blocks M1 acetylcholine receptors, physically restoring the delicate balance between dopamine and acetylcholine. This prevents the “drug-induced Parkinsonism” that often leads patients to abandon therapy.
• Mechanism 3 (The Multi-Receptor Sedative Effect): Chlorpromazine also possesses significant antihistaminic and alpha-adrenergic blocking activity. This provides a deep, reliable sedative effect, making it the globally preferred choice for managing “uncontrolled” or violent psychiatric crises in institutional settings.

Product Composition & Strength

We supply this product in Precision-Blended configurations, often customized for institutional titration, packed in secure, moisture-resistant Alu-PVC or Alu-Alu blister strips.

*Pack Sizes: 10×10 Blisters or Bulk Jars of 1000 (Optimized specifically for high-volume psychiatric hospital dispensing).

Technical & Logistics Specifications

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• CNS High-Containment & Precision Blending (CRITICAL COMPLIANCE): Chlorpromazine is a potent sedative and antipsychotic. Our facility utilizes Strictly Segregated CNS Suites to prevent cross-contamination with other drugs. Furthermore, we utilize Multi-Stage Geometric Dilution to ensure that the 2mg of Trihexyphenidyl is perfectly distributed. We provide global buyers with a product that delivers the exact, life-saving dose required for institutional mental health safety.

Therapeutic Indications

• Chronic Schizophrenia: Long-term management of positive symptoms (hallucinations, delusions).
• Acute Psychotic Agitation: Rapid behavioral control of violent or aggressive psychiatric patients.
• Drug-Induced Extrapyramidal Symptoms: Prevention of tremors, akathisia, and dystonia caused by antipsychotic therapy.
• Intractable Hiccups & Nausea: Off-label use for severe, non-responsive hiccups and chemotherapy-induced emesis.

Dosage & Administration

• Psychosis: Initially 25 mg to 50 mg (Chlorpromazine) TID, adjusted based on patient response. 2mg (Trihexyphenidyl) is typically co-administered 2-3 times daily.
• The Institutional Taper: Doses should be adjusted to the lowest effective level for maintenance to reduce the long-term risk of Tardive Dyskinesia.

Safety Warnings (CRITICAL):

• Tardive Dyskinesia (FATAL Side Effect): Long-term use of FGAs can cause irreversible, involuntary muscle movements. Patients must be monitored using the AIMS scale.
• Neuroleptic Malignant Syndrome (NMS): A rare but potentially fatal reaction characterized by high fever, muscle rigidity, and altered mental status. Must stop treatment immediately if fever occurs.
• Anticholinergic Risk: Trihexyphenidyl can cause dry mouth, blurred vision, and urinary retention. Strictly contraindicated in patients with Narrow-Angle Glaucoma.
• Photosensitivity: Chlorpromazine can cause severe skin reactions to sunlight. Patients must avoid direct sun exposure.

Global Export & Contract Manufacturing Services

Healthy Inc is a premier Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume Psychiatric FDCs and CNS therapeutics. Whether you are a Government Tender Supplier for mental health institutes in Africa or a B2B Pharma Marketplace partner in Latin America, we ensure secure, WHO-GMP compliant delivery.