Description

Cefotaxime Sodium Injection

Healthy Inc is a specialized global supplier and exporter of high-safety third-generation cephalosporins. We provide high-purity Cefotaxime Sodium Injection (1g / 500mg / 250mg), sourced from WHO–GMP certified sterile injectable facilities. This “Blood-Brain Barrier Specialist” is a top export to neonatal intensive care units (NICU), neurology wards, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the gold standard for treating bacterial meningitis and severe infections in newborns.

Product Overview

This formulation contains Cefotaxime Sodium, a third-generation cephalosporin distinguished by its exceptional safety profile and metabolic stability.

The “Safe Passage” Specialist:

• Meningitis Master: Unlike many other antibiotics, Cefotaxime has excellent penetration into the Cerebrospinal Fluid (CSF) when the meninges are inflamed. This makes it the drug of choice for treating bacterial meningitis caused by Neisseria meningitidis, H. influenzae, and Streptococcus pneumoniae.
• Neonatal Safety (The “Jaundice” Advantage): Unlike Ceftriaxone, Cefotaxime has low affinity for albumin and does not displace bilirubin. This makes it the safest cephalosporin for neonates, as it avoids the risk of kernicterus (brain damage from jaundice), allowing its use even in premature infants.
• Active Metabolite: It is metabolized in the liver to Desacetyl-cefotaxime, which is also an active antibiotic. This metabolite works synergistically with the parent drug, providing a “double-hit” against pathogens.

Product Composition & Strength

We supply this product as a Sterile Dry Powder for Injection in glass vials. The sodium content is lower than many other cephalosporins (approx 2.2 mmol/g).

*Pack Sizes: Tray of 1 Vial, 10 Vials, 50 Vials, or Box of 1/10 Vials with Water for Injection (WFI).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Color Stability: Cefotaxime is sensitive to light and heat, turning yellow-brown if degraded. We use advanced sterile crystallization and light-protective packaging to ensure the powder remains white to pale yellow, indicating maximum potency.
• Endotoxin Control: Because it is frequently used in high doses for meningitis (traversing the blood-brain barrier), our endotoxin limits are strictly controlled to prevent inflammatory responses in the CNS.

Therapeutic Indications (Human Use)

Indicated for the treatment of serious infections:

• Bacterial Meningitis: Drug of choice for empirical therapy in children and adults.
• Neonatal Sepsis: First-line treatment for sepsis in newborns (0-28 days).
• Gonorrhea: Single-dose treatment for penicillinase-producing N. gonorrhoeae (PPNG).
• Lyme Disease: Neurological or cardiac manifestations (Neuroborreliosis).
• Respiratory Tract: Severe pneumonia.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Route: Intravenous (IV) Injection/Infusion or Deep IM.
• Adults (Standard): 1 g every 12 hours.
• Meningitis (Adults): 2 g every 4 to 8 hours (High Dose).
• Neonates (0-1 week): 50 mg/kg every 12 hours.
• Neonates (1-4 weeks): 50 mg/kg every 8 hours.
• Gonorrhea: 500 mg or 1 g single IM dose.
• Renal Impairment: Reduce dose if Creatinine Clearance < 20 ml/min.

Safety Warnings (CRITICAL):

• Arrhythmia: Rapid IV bolus (less than 1 minute) can cause potentially life-threatening arrhythmia. Inject slowly over 3-5 minutes.
• Penicillin Allergy: CONTRAINDICATED in patients with a history of anaphylaxis to penicillins or cephalosporins.
• Colitis: Antibiotic-associated pseudomembranous colitis can occur.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.