Description
Candesartan Cilexetil Tablets
Healthy Inc is a specialized global supplier and exporter of premium cardiovascular therapeutics. We provide high-purity Candesartan Cilexetil Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Insurmountable” Angiotensin Receptor Blocker (ARB) is a top export to cardiology clinics, government health formularies, and pharmacy chains in Africa, LATAM, and Southeast Asia, recognized for its potent, long-lasting blood pressure control and efficacy in heart failure management.
Product Overview
This formulation contains Candesartan Cilexetil, a prodrug that is rapidly converted to the active drug Candesartan during absorption.
The “Tight Binding” Specialist:
- Mechanism: Candesartan works by selectively blocking the binding of Angiotensin II to the AT1 receptor in vascular smooth muscle and the adrenal gland. Angiotensin II is a potent vasoconstrictor; blocking it causes blood vessels to relax and blood pressure to drop.
- Insurmountable Antagonism: Unlike some other ARBs (like Losartan), Candesartan binds extremely tightly to the receptor and dissociates very slowly. This results in “insurmountable” blockade, providing stable, 24-hour blood pressure control with no “trough” effect before the next dose.
- Heart Failure Benefit: It is clinically proven (CHARM trials) to reduce cardiovascular death and hospital admissions in patients with heart failure and reduced left ventricular ejection fraction (LVEF).
- Prodrug Design: The Cilexetil ester improves bioavailability. It is completely hydrolyzed to active Candesartan during absorption from the gastrointestinal tract.
Product Composition & Strength
We supply this product as Uncoated Tablets (scored). The wide range of strengths allows for precise titration in heart failure patients.
| Active Ingredient | Strength (Standard) | Primary Role |
|---|---|---|
| Candesartan Cilexetil USP/BP | 4 mg | Heart Failure Initiation / Hepatic Impairment |
| Candesartan Cilexetil USP/BP | 8 mg | Standard Hypertension Start |
| Candesartan Cilexetil USP/BP | 16 mg | Standard Maintenance |
| Candesartan Cilexetil USP/BP | 32 mg | High Dose / Resistant Hypertension |
*Pack Sizes: Alu-Alu Blister packs of 10s (Box of 10×10), 14s, 28s (Calendar Pack), or Bulk HDPE Jars of 500s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | Alu-Alu Blister (Highly Moisture/Light Sensitive) |
| Storage | Store below 25°C. Protect from Moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Stability Engineering: Candesartan Cilexetil is sensitive to temperature, light, and humidity. Degradation can lead to the formation of impurities (desethyl candesartan). We utilize cold-form Alu-Alu packaging and controlled processing environments to ensure the product retains >99% assay throughout its shelf life.
- Bioequivalence: Our formulation uses micronized API and specific disintegrants to match the dissolution profile of the innovator (Atacand), ensuring consistent conversion from prodrug to active drug.
Therapeutic Indications (Human Use)
Indicated for the management of cardiovascular conditions:
- Hypertension: Treatment of high blood pressure in adults and children (1 to <17 years). Can be used alone or with other agents (e.g., Thiazides).
- Heart Failure: Treatment of heart failure (NYHA class II-IV) in adults with left ventricular systolic dysfunction (ejection fraction ≤ 40%) to reduce cardiovascular death and heart failure hospitalization.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Hypertension (Adults): Start with 16 mg once daily. Dose can be titrated to 32 mg once daily.
- Heart Failure:
- Initial: 4 mg once daily.
- Titration: Double the dose at 2-week intervals (4mg -> 8mg -> 16mg -> 32mg) as tolerated by the patient.
- Target Dose: 32 mg once daily.
- Renal Impairment: No initial adjustment needed for mild impairment. Start lower in severe cases.
Safety Warnings:
- Pregnancy (Black Box Warning): Strictly Contraindicated. Drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus. Stop immediately if pregnancy is detected.
- Hyperkalemia: Can increase serum potassium levels, especially in heart failure patients or those on potassium-sparing diuretics. Regular monitoring is required.
- Hypotension: Symptomatic low blood pressure may occur in volume-depleted patients.
- Renal Function: Monitor serum creatinine; may cause acute renal failure in patients with renal artery stenosis.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
