Description

Venlafaxine Extended-Release (ER) Tablets

Healthy Inc is a specialized global supplier and exporter of advanced psychiatric, neurological, and central nervous system (CNS) therapeutics. We provide high-purity, kinetically controlled Venlafaxine Hydrochloride Extended-Release Tablets (37.5 mg / 75 mg / 150 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Dual-Action SNRI Antidepressant” is a massive-volume, premium export to psychiatric hospitals, mental health NGOs, primary care networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally trusted, second-line and treatment-resistant intervention for Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), and severe Panic Disorder.

Product Overview

This formulation contains Venlafaxine Hydrochloride, a structurally novel, highly potent inhibitor of neuronal serotonin and norepinephrine reuptake, engineered to restore critical, multi-pathway neurotransmitter balance in the brain.

The “Dual-Action Mood & Anxiety” Specialist:

• Mechanism (Dose-Dependent SNRI Blockade): Venlafaxine acts as a sequential dual-reuptake inhibitor. At lower doses (e.g., 75 mg), it acts primarily like a highly potent SSRI, blocking only serotonin reuptake. However, as the dose escalates (150 mg and above), it aggressively blocks the reuptake of Norepinephrine, providing a massive, activating surge in energy, focus, and drive. At even higher doses, it weakly inhibits dopamine reuptake.
• The Treatment-Resistant Champion: For the millions of patients who experience emotional “blunting” or lack of clinical response to standard SSRIs (like Fluoxetine or Sertraline), the addition of the norepinephrine blockade makes Venlafaxine the global standard-of-care for treatment-resistant depression and paralyzing, chronic anxiety disorders.
• The Sustained-Release Imperative: Immediate-release Venlafaxine spikes rapidly in the blood, causing severe, intolerable nausea and vomiting in most patients. Our Extended-Release (ER) tablet formulation slowly leaches the medication into the gastrointestinal tract over 24 hours, flattening the pharmacokinetic peak, drastically improving gastric tolerability, and allowing for convenient once-daily dosing.

Product Composition & Strength

We supply this product as a highly advanced Extended-Release (ER) Film-Coated Tablet, packed in highly secure, moisture-resistant Alu-PVC or opaque Alu-Alu blister strips to preserve the integrity of the controlled-release polymer matrix.

*Pack Sizes: 10×10 or 10×14 Blisters / HDPE Bottles of 30/100 Tablets (Optimized for 30-day chronic psychiatric adherence regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Psychiatric Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Advanced Polymer Matrix Engineering: Manufacturing a 24-hour Extended-Release tablet requires exceptionally precise pharmaceutical engineering. Our facilities utilize advanced high-shear granulation to lock the Venlafaxine API within a specialized hypromellose (HPMC) gel-forming matrix. This prevents “dose dumping” in the stomach and guarantees a smooth, continuous therapeutic blood level.
• Dissolution Profiling: Rigorous in vitro dissolution testing across multiple pH mediums (simulating the entire gastrointestinal tract) ensures the tablet releases the API reliably over the mandated 24-hour window, perfectly matching the pharmacokinetic profile of the originator brand.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of severe psychiatric and mood disorders:

• Major Depressive Disorder (MDD): Acute and maintenance treatment of severe, persistent clinical depression in adults.
• Generalized Anxiety Disorder (GAD): Treatment of excessive, difficult-to-control daily anxiety and worry.
• Social Anxiety Disorder (SAD): Treatment of severe, paralyzing social phobia.
• Panic Disorder: Treatment of panic attacks, with or without agoraphobia.
• Off-Label Use: Frequently prescribed off-label for the management of chronic neuropathic pain, migraine prophylaxis, and vasomotor symptoms (hot flashes) in menopause.

Dosage & Administration

Recommended Dosage (Strictly as per Psychiatrist/Physician Guidelines):

• Administration (FOOD REQUIREMENT): Venlafaxine ER MUST be taken with food, at approximately the same time each day (usually in the morning to prevent insomnia).
• Swallowing Protocol (CRITICAL): The tablet MUST be swallowed whole with fluid. It must never be divided, crushed, chewed, or dissolved, as this will instantly destroy the extended-release matrix, causing a massive, potentially toxic overdose of the drug into the bloodstream.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING (Suicidality): All antidepressants increase the risk of suicidal thinking and behavior in children, adolescents, and young adults (up to age 24) during the initial months of therapy or during dose changes. Patients must be monitored closely for clinical worsening.
• Severe Discontinuation Syndrome (“Brain Zaps”): Venlafaxine is globally notorious for causing severe withdrawal symptoms if stopped abruptly or if even a single dose is missed. Symptoms include agonizing “electric shock” sensations in the brain (brain zaps), severe vertigo, nausea, and nightmares. The drug MUST be tapered off extremely slowly over weeks or months.
• Sustained Hypertension: Because Venlafaxine blocks the reuptake of norepinephrine, it frequently causes a dose-related, sustained elevation in blood pressure. Pre-existing hypertension must be controlled before initiating therapy, and blood pressure must be monitored regularly.
• Serotonin Syndrome: Co-administration with other serotonergic drugs (like MAOIs, Triptans, or Tramadol) can trigger a potentially fatal accumulation of serotonin.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Psychiatric Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government mental health programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.