Description

Trimetazidine Tablets

Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, metabolic, and geriatric therapeutics. We provide ultra-high-purity, kinetically controlled Trimetazidine Dihydrochloride Tablets (35 mg Modified-Release / 20 mg Immediate-Release), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Cellular Anti-Ischemic Metabolic Modulator” is a massive-volume, essential export to cardiology centers, geriatric care networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally trusted, first-line add-on intervention for the symptomatic treatment of stable angina pectoris.

Product Overview

This formulation contains Trimetazidine Dihydrochloride, a fundamentally unique cardioprotective agent that defends the heart muscle during periods of low oxygen (ischemia) without altering the patient’s hemodynamics.

The “Myocardial Energy Optimization” Specialist:

• Mechanism (The Metabolic Shift): During an angina attack, the heart muscle is starved of oxygen. Normally, the heart burns fatty acids for energy, which requires a massive amount of oxygen. Trimetazidine physically blocks an enzyme called 3-KAT. This forces the heart cells to stop burning fat and start burning glucose instead. Glucose oxidation requires significantly less oxygen to produce the same amount of cellular energy (ATP). By “optimizing the fuel,” the heart continues to beat strongly even when its oxygen supply is cut off by clogged arteries.
• The Non-Hemodynamic Advantage: Standard angina drugs (like Beta-Blockers or Calcium Channel Blockers) work by artificially slowing down the heart or dropping blood pressure. This often leaves elderly patients feeling exhausted or dizzy. Trimetazidine is purely metabolic; it has zero effect on heart rate or blood pressure, making it the perfect, safe add-on therapy for fragile geriatric patients whose hemodynamics cannot be further suppressed.
• Modified-Release (MR) Protection: Immediate-release formulations cause rapid spikes and crashes in drug blood levels. Our 35mg Modified-Release (MR) tablets utilize an advanced polymer matrix to slowly leach the cardioprotective agent into the bloodstream, guaranteeing continuous, 24-hour defense against ischemic attacks with convenient twice-daily dosing.

Product Composition & Strength

We supply this product as an advanced Modified-Release (MR) Film-Coated Tablet, packed in highly secure, moisture-resistant Alu-Alu blister strips to ensure the stability of both the active ingredient and the kinetic polymer matrix.

*Pack Sizes: 10×10 or 10×14 Alu-Alu Blisters (Optimized for 30-day chronic cardiology adherence regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Cardiology Distributors, and Geriatric Networks.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Advanced Polymer Matrix Engineering: Manufacturing a reliable Modified-Release tablet requires highly sophisticated formulation. Our facilities utilize advanced high-shear wet granulation to embed the Trimetazidine API deep within a specialized hypromellose gel-forming matrix, preventing dangerous “dose dumping” in the stomach.
• Multipoint Dissolution Profiling: Rigorous in vitro dissolution testing across multiple simulated gastric and intestinal pH mediums ensures the tablet releases the drug smoothly and consistently, perfectly matching the pharmacokinetic steady-state of the originator brand.

Therapeutic Indications (Human Use)

Indicated for the comprehensive metabolic management of severe cardiovascular disease:

• Stable Angina Pectoris: Indicated strictly as an add-on therapy for the symptomatic treatment of adult patients with stable angina pectoris who are inadequately controlled by, or completely intolerant to, first-line antianginal therapies (like beta-blockers).

Dosage & Administration

Recommended Dosage (Strictly as per Cardiologist/Physician Guidelines):

• Standard Dosing (35 mg MR): One 35 mg tablet taken twice daily, once in the morning and once in the evening.
• Administration (GASTRIC TOLERABILITY): The tablets MUST be taken with meals (e.g., during breakfast and dinner) to ensure optimal absorption and prevent mild gastrointestinal discomfort.
• Swallowing Protocol (CRITICAL): Modified-Release tablets MUST be swallowed whole with a glass of water. They must never be chewed, crushed, or split, as this immediately destroys the delayed-release matrix.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Neurological Warning (Parkinsonian Symptoms): Trimetazidine is known to occasionally cause or worsen Parkinsonian symptoms (tremors, akinesia, hypertonia), unsteady gait, and restless leg syndrome, particularly in elderly patients. It is strictly contraindicated in patients with pre-existing Parkinson’s disease, severe tremors, or movement disorders. If movement disorders emerge, the drug must be permanently discontinued.
• Renal Contraindication: The drug is primarily excreted by the kidneys. It is strictly contraindicated in patients with severe renal impairment (creatinine clearance < 30 ml/min).
• Not for Acute Attacks: Patients must be rigorously counseled that Trimetazidine is a chronic maintenance drug. It is NOT a rescue medication. It will not stop an active angina attack and should never be used in place of sublingual Nitroglycerin during an acute cardiac event.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for geriatric cardiac programs in Africa or a B2B Pharma Marketplace partner for Southeast Asia, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.