Description

Tizanidine Tablets (2 mg)

Healthy Inc is a specialized global supplier and exporter of advanced neurological, rehabilitative, and musculoskeletal therapeutics. We provide ultra-high-purity, kinetically precise Tizanidine Tablets (2 mg), manufactured in WHO–GMP certified, high-capacity oral solid dosage facilities. This “Central Alpha-2 Adrenergic Agonist” is a massive-volume, essential export to neurology centers, spinal cord rehabilitation clinics, pain management networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally trusted, first-line intervention for severe spasticity and painful, acute muscle spasms.

Product Overview

This formulation contains Tizanidine (as Tizanidine Hydrochloride), a highly potent, centrally acting skeletal muscle relaxant that operates entirely differently from standard benzodiazepines or legacy antispasmodics.

The “Neurological Spasticity & Motor Inhibition” Specialist:

• Mechanism (Spinal Cord Alpha-2 Agonism): Tizanidine does not directly relax the muscle fibers themselves. Instead, it acts centrally within the spinal cord. By aggressively stimulating alpha-2 adrenergic receptors, it violently inhibits the release of excitatory amino acids (like glutamate) from spinal interneurons. This drastically reduces the hyperactive reflex signals being sent to the muscles, effectively shutting off the spasm at the neurological level.
• The MS and Spinal Injury Champion: For patients suffering from Multiple Sclerosis (MS) or severe spinal cord injuries, muscle spasticity is constant, painful, and debilitating. Tizanidine is globally mandated for these conditions because it provides profound muscle relaxation without paralyzing the patient or causing the severe muscle weakness associated with drugs like Baclofen or Dantrolene.
• The 2mg Titration Imperative: Tizanidine causes a significant, dose-dependent drop in blood pressure. To prevent patients from fainting (syncope), therapy must be initiated at a highly precise 2 mg dose, allowing the cardiovascular system to acclimate before titrating up to higher therapeutic levels.

Product Composition & Strength

We supply this product as a Precision-Blended Uncoated Tablet, packed in highly secure, moisture-resistant Alu-PVC or opaque Alu-Alu blister strips, optimized with a deep score-line to allow for exact 1 mg micro-dosing if required by pediatric or highly sensitive geriatric patients.

*Pack Sizes: 10×10 or 10×15 Blisters (Optimized for rapid titration and frequent dosing regimens). Higher strengths (4 mg) available for advanced maintenance therapy.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Neurology Distributors, and Rehabilitation Clinics.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Micro-Dose Geometric Blending: Because the active ingredient is potent at just 2 milligrams, uneven powder mixing can result in tablets with sub-therapeutic doses or dangerously high amounts that could trigger severe hypotension. Our facilities utilize advanced high-shear homogenizers and rigorous geometric dilution protocols, verified by HPLC assay, to guarantee absolute dose uniformity across millions of units.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of pathologically elevated muscle tone:

• Neurological Spasticity: Management of severe spasticity associated with Multiple Sclerosis (MS), spinal cord injury, acquired brain injury, or cerebral palsy.
• Acute Musculoskeletal Spasms: Short-term adjunctive therapy for painful, acute muscle spasms (often prescribed off-label for severe back pain when sedation/sleep is desired).

Dosage & Administration

Recommended Dosage (Strictly as per Neurologist/Physician Guidelines):

• Initiation Protocol: Therapy must begin at 2 mg taken orally. The dose can be repeated at 6 to 8-hour intervals, as the drug has a very short duration of action.
• Administration (THE FOOD CONSISTENCY RULE): Food profoundly alters the pharmacokinetics (absorption profile) of Tizanidine. Taking it with food increases the peak blood concentration by up to 30%. Patients MUST be strictly counseled to take the drug the exact same way every time (either always with food, or always on an empty stomach) to prevent sudden, unexpected spikes in blood pressure drops or sedation.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX EQUIVALENT (Severe CYP1A2 Interactions): Tizanidine is extensively metabolized in the liver by the CYP1A2 enzyme. Co-administration with strong CYP1A2 inhibitors (specifically Fluvoxamine or Ciprofloxacin) is STRICTLY CONTRAINDICATED. Mixing these drugs causes Tizanidine blood levels to spike up to 10-fold, resulting in profound, prolonged, and potentially fatal hypotension and central nervous system depression.
• Severe Hypotension & Syncope: Tizanidine is an alpha-2 agonist (closely related to the blood pressure drug Clonidine). It frequently causes severe drops in blood pressure, leading to dizziness, fainting, and bradycardia. Extreme caution is required in patients receiving concurrent antihypertensive therapy.
• Hepatotoxicity: Rare but severe liver injury has been reported. Liver transaminases (ALT, AST) must be monitored for the first 6 months of treatment.
• Rebound Hypertension (Withdrawal): If a patient has been on chronic, high-dose Tizanidine, it MUST NEVER be stopped abruptly. Sudden discontinuation can trigger a severe withdrawal syndrome characterized by massive rebound hypertension, tachycardia, and hypertonia. It must be tapered slowly.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Neurological and Orthopedic Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for rehabilitation programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.