Description

Telmisartan & Metoprolol Succinate (Enteric-Coated) Tablets

Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, antihypertensive, and post-myocardial infarction therapeutics. We provide ultra-high-purity, kinetically segregated Telmisartan (50 mg) & Metoprolol Succinate (40 mg Enteric-Coated / Prolonged-Release) Tablets, manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Dual-Action Cardioprotective Synergy” is a highly specialized, premium export to cardiology centers, intensive care step-down units, primary care networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the definitive intervention for severe, treatment-resistant hypertension and chronic ischemic heart disease.

Product Overview

This highly advanced Fixed-Dose Combination (FDC) brilliantly synchronizes Telmisartan, the longest-acting Angiotensin II Receptor Blocker (ARB), with Metoprolol Succinate, the undisputed global gold-standard cardioselective beta-blocker.

The “Complete Hemodynamic Blockade” Specialist:

• Mechanism 1 (The Afterload Reducer – Telmisartan): Telmisartan aggressively binds to the AT1 receptors on blood vessels, preventing the constricting action of Angiotensin II. This creates massive, sustained vasodilation, dropping the resistance (afterload) that the heart must pump against, while simultaneously protecting the kidneys and improving insulin sensitivity.
• Mechanism 2 (The Heart Rate Controller – Metoprolol): While Telmisartan opens the blood vessels, Metoprolol Succinate acts directly on the heart muscle. By selectively blocking Beta-1 adrenergic receptors, it dramatically slows the resting heart rate, reduces the force of cardiac contractions, and blocks the release of renin from the kidneys. This fundamentally lowers the heart’s oxygen demand, preventing angina attacks and shielding the heart from fatal arrhythmias.
• The Enteric-Coated Kinetic Advantage: The 40 mg Metoprolol Succinate component is meticulously formulated with an advanced Enteric Coating / Sustained-Release matrix. This ensures the beta-blocker safely bypasses the acidic environment of the stomach and slowly releases in the alkaline intestine over 24 hours. This eliminates the dangerous spikes and crashes in heart rate associated with immediate-release beta-blockers, preventing sudden spells of dizziness or fainting.

Product Composition & Strength

We supply this product as a Precision-Engineered Bilayer Film-Coated Tablet, packed exclusively in highly secure, moisture-resistant Alu-Alu blister strips to ensure the absolute stability of both the hygroscopic ARB and the kinetic polymer matrix.

*Pack Sizes: 10×10 or 10×15 Alu-Alu Blisters (Optimized specifically for strict 30-day chronic cardiology adherence regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Cardiology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Alkaline-Enteric Segregation Engineering: Manufacturing this specific FDC is incredibly complex. Telmisartan requires highly alkaline stabilizers (like Meglumine) to dissolve, but alkalinity instantly destroys the enteric coating of Metoprolol. Our facilities utilize advanced Bilayer Tablet Pressing Technology. This physically separates the Telmisartan layer from the Enteric-Coated Metoprolol Succinate pellets, guaranteeing zero cross-reactivity during shelf life and ensuring flawless, perfectly timed release profiles in the gastrointestinal tract.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of severe cardiovascular disease:

• Essential Hypertension: Treatment of moderate-to-severe high blood pressure in patients whose blood pressure is not adequately controlled on Telmisartan or Metoprolol monotherapy, or as substitution therapy for patients already controlled on the individual components.
• Chronic Stable Angina & Post-MI Care: Prophylactic management of angina pectoris and reduction of cardiovascular mortality in patients with a history of myocardial infarction (heart attack).

Dosage & Administration

Recommended Dosage (Strictly as per Cardiologist Guidelines):

• Standard Adult Dosing: One tablet taken orally once daily, preferably in the morning to blunt the early-morning surge in blood pressure and heart rate.
• Swallowing Protocol (CRITICAL): Because the Metoprolol component is Enteric-Coated and prolonged-release, the tablet MUST be swallowed whole with a glass of water. It must never be crushed, chewed, or divided, as this will destroy the enteric matrix, causing severe gastric distress and an immediate, dangerous overdose of the beta-blocker.
• Administration: Can be taken with or without food.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX WARNING (Fetal Toxicity): Like all drugs acting on the renin-angiotensin system, the Telmisartan component can cause catastrophic injury and death to the developing fetus. Strictly contraindicated in pregnancy.
• Bradycardia & Heart Blocks: Metoprolol severely depresses heart rate and AV node conduction. It is strictly contraindicated in patients with severe bradycardia (resting heart rate < 45 bpm), second or third-degree heart block, sick sinus syndrome, or uncompensated heart failure.
• Masking of Hypoglycemia: Beta-blockers can mask the physical symptoms of low blood sugar (specifically the rapid heartbeat and tremors) in diabetic patients. Diabetics must be rigorously counseled to monitor their blood glucose levels closely.
• Asthma Contraindication: Although Metoprolol is “cardioselective,” at higher doses it can spill over and block beta-2 receptors in the lungs, triggering fatal bronchospasm. Extreme caution is required in patients with severe asthma or COPD.
• Abrupt Withdrawal Warning: This medication MUST NEVER be stopped abruptly. Sudden discontinuation of Metoprolol can trigger a massive surge in catecholamines, leading to severe angina, acute myocardial infarction, or fatal ventricular arrhythmias. It must be tapered slowly over 1-2 weeks.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular FDCs, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for post-MI programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.