Description

Sodium Bicarbonate Injection

Healthy Inc is a specialized global supplier and exporter of essential life-saving critical care therapies. We provide high-purity Sodium Bicarbonate Injection (8.4% w/v), manufactured in WHO–GMP certified sterile fluid facilities. This “Systemic Alkalinizer” is a mandatory export to emergency departments, intensive care units (ICU), nephrology centers, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the frontline intervention for severe metabolic acidosis, toxicological emergencies, and life-threatening hyperkalemia.

Product Overview

This formulation contains Sodium Bicarbonate (NaHCO3), a sterile, nonpyrogenic, hypertonic solution acting as an immediate systemic blood alkalinizer.

The “Acidosis Reverser” Specialist:

• Mechanism (Hydrogen Ion Buffering): In the blood, Sodium Bicarbonate dissociates to provide a massive influx of bicarbonate ions (HCO3-). These ions rapidly bind with free, toxic hydrogen ions (H+) to form carbonic acid, which then breaks down into water and carbon dioxide (exhaled by the lungs). This immediately pulls the blood pH out of dangerous acidemia back toward a normal 7.4.
• Emergency Crash Cart Utility: While modern ACLS guidelines have narrowed its use in standard cardiac arrest, it remains absolutely critical for prolonged cardiac arrest complicated by pre-existing metabolic acidosis, hyperkalemia, or tricyclic antidepressant (TCA) overdose.
• Toxicology & Urinary Alkalinization: Intravenous administration raises the pH of the urine. This is a vital antidotal treatment for overdoses of weak acids (like Aspirin/Salicylates and Phenobarbital), trapping the toxic molecules in the renal tubules and accelerating their excretion from the body.

Product Composition & Strength

We supply this product as a Sterile, Clear, Colorless Aqueous Solution in glass ampoules or vials.

*Pack Sizes: 10 ml Ampoules (Tray of 50), 50 ml Vials, or 100 ml Vials.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• pH and Carbonate Control: Manufacturing highly concentrated sodium bicarbonate is chemically sensitive. Our process strictly controls the headspace CO2 gas equilibrium and pH (7.0 to 8.5) during filling to prevent the conversion of bicarbonate into highly alkaline, tissue-damaging sodium carbonate.
• Terminal Sterilization: The filled ampoules and vials undergo validated terminal autoclaving to ensure a 100% pyrogen-free product suitable for direct central line or emergency peripheral IV administration.

Therapeutic Indications (Human Use)

Indicated for emergency and critical care metabolic management:

• Severe Metabolic Acidosis: Occurring in severe renal disease, uncontrolled diabetes (DKA), profound shock, or severe dehydration.
• Cardiac Arrest: As per current ACLS guidelines, reserved for special resuscitation situations (pre-existing metabolic acidosis, hyperkalemia, or TCA overdose).
• Hyperkalemia: Causes a rapid, temporary shift of potassium ions from the blood into the cells, protecting the heart from fatal arrhythmias.
• Toxicity & Poisoning: Alkalinization of urine to accelerate the renal excretion of salicylates, barbiturates, and to treat tricyclic antidepressant cardiotoxicity.

Dosage & Administration

Recommended Dosage (Strictly as per ER Physician/Intensivist):

• Route: Slow Intravenous (IV) Injection or Continuous IV Infusion.
• Cardiac Arrest (Adults): Initial dose of 1 mEq/kg (usually one 50 ml vial of the 8.4% solution) administered via rapid IV push. Subsequent doses should be based on arterial blood gas (ABG) analysis.
• Less Urgent Acidosis: Typically added to IV fluids (like 5% Dextrose) and infused slowly over 4 to 8 hours to avoid rapid shifts in cerebrospinal fluid pH.
• Neonatal Warning: Do not use 8.4% in neonates. Must use a diluted 4.2% (0.5 mEq/ml) solution injected extremely slowly (max 1 mEq/kg/min) to prevent fatal intracranial hemorrhage from sudden hyperosmolarity.

Safety Warnings (CRITICAL):

• Calcium Incompatibility (PRECIPITATION RISK): NEVER mix Sodium Bicarbonate with calcium-containing IV fluids (like Ringer’s Lactate or Calcium Gluconate) in the same IV line. It causes immediate, lethal precipitation of chalk-like calcium carbonate crystals that will cause fatal embolisms. Flush IV lines thoroughly.
• Extravasation (Tissue Necrosis): Because 8.4% is intensely hypertonic, leakage outside the vein will cause severe chemical burns, tissue sloughing, and necrosis. Ensure secure IV access.
• Sodium Overload: Contains massive amounts of sodium. Can trigger acute pulmonary edema in patients with congestive heart failure or severe renal impairment.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Emergency Resuscitation Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.