Description

Senna Tablets (12 mg Sennosides)

Healthy Inc is a specialized global supplier and exporter of advanced gastroenterological, geriatric, and botanical-derived therapeutics. We provide ultra-high-purity, pharmacopeially standardized Senna Film-Coated Tablets (12 mg), manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Botanical Stimulant Laxative” is a massive-volume, high-turnover export to gastroenterology clinics, global retail pharmacy networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally trusted, natural intervention for the predictable overnight relief of acute and chronic constipation.

Product Overview

This formulation contains Sennosides, the highly purified, active anthraquinone derivatives extracted from the pods and leaves of the Senna plant (Cassia angustifolia). It acts as a highly reliable, natural prodrug that specifically targets the lower gastrointestinal tract.

The “Botanical Colonic Stimulant” Specialist:

• Mechanism 1 (Bacterial Prodrug Activation): Like synthetic colonic laxatives, Sennosides are natural prodrugs. When swallowed, they travel intact and completely unabsorbed through the stomach and small intestine, causing zero upper GI distress. Once they reach the colon, the resident gut bacteria aggressively metabolize the sennosides into their active form: rhein anthrone.
• Mechanism 2 (Vigorous Peristalsis & Hydration): The active rhein anthrone directly irritates and stimulates the myenteric plexus (the nerve supply to the gastrointestinal tract) within the colon wall. This triggers vigorous, rhythmic muscle contractions (peristalsis) that push the stool forward. Simultaneously, it actively inhibits the absorption of water and electrolytes from the colon, keeping the stool highly hydrated, soft, and easy to pass.
• The “Opioid-Induced” Champion: Senna is the globally mandated, first-line clinical standard for counteracting the severe, paralyzing constipation caused by heavy opioid painkillers (like Morphine or Oxycodone) in post-operative and palliative oncology care.

Product Composition & Strength

We supply this product as a Precision-Blended Film-Coated or Uncoated Tablet, packed in highly secure, moisture-resistant PVC/PVDC or Alu-PVC blister strips to ensure the absolute chemical stability of the botanical extract.

*Pack Sizes: 10×10 Blisters or Bottles of 100 (Optimized specifically for high-turnover retail pharmacy shelves and chronic geriatric/oncology hospital dispensing).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, OTC Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Strict Botanical Standardization (CRITICAL COMPLIANCE): The clinical efficacy of natural Senna is highly variable depending on the plant’s growing conditions. Our clinical-grade Senna is strictly validated via High-Performance Liquid Chromatography (HPLC) to guarantee an exact 12 mg standardized yield of active Sennosides per tablet, alongside rigorous screening to ensure absolute zero presence of heavy metals or agricultural pesticides.

Therapeutic Indications (Human Use)

Indicated for the targeted management of colonic motility disorders:

• Constipation: Short-term treatment of acute and chronic constipation of various etiologies.
• Opioid-Induced Constipation (OIC): Routine prophylaxis and treatment of severe bowel paralysis in patients undergoing opioid analgesic therapy.
• Bowel Evacuation: Adjunctive therapy to evacuate the bowel prior to radiological procedures, endoscopy, or surgery.

Dosage & Administration

Recommended Dosage (Strictly as per Physician/Pharmacist Guidelines):

• Standard Adult Dosing: 1 to 2 tablets (12 mg to 24 mg) taken orally once a day. (Maximum dose typically should not exceed 34.4 mg per day).
• Administration (THE BEDTIME RULE): To produce a highly predictable bowel movement the following morning (onset is 6 to 12 hours), the tablet should be taken at night before retiring.
• Duration of Use: As with all stimulant laxatives, Senna should generally not be used for more than 1 week without direct medical supervision.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Melanosis Coli (Signature Side Effect): Chronic use of Senna causes a benign, dark brown-to-black discoloration of the mucosal lining of the colon (melanosis coli), which is visible during a colonoscopy. It is harmless and reverses once the medication is stopped, but patients and physicians must be aware of it to prevent misdiagnosis.
• Hypokalemia & Electrolyte Imbalance: Prolonged or excessive use forces the colon to excrete massive amounts of water and essential salts. This can lead to severe dehydration and dangerous Hypokalemia (low potassium), which can trigger fatal cardiac arrhythmias.
• “Lazy Bowel” Syndrome (Dependency): Chronic daily use causes the colon muscles to lose their natural tone and become entirely dependent on the chemical stimulant to function.
• Acute Abdomen Contraindication: Strictly contraindicated in patients suffering from undiagnosed severe abdominal pain, intestinal obstruction, or acute inflammatory bowel diseases (like appendicitis), as it can trigger a fatal intestinal rupture.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Gastroenterological and OTC Botanical Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Pharmacy Chain Supplier for geriatric care programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.