Description

Rabeprazole Sodium Enteric-Coated Tablets (10 mg / 20 mg)

Healthy Inc is a specialized global supplier and exporter of advanced gastroenterological, anti-ulcerant, and internal medicine therapeutics. We provide ultra-high-purity, kinetically stabilized Rabeprazole Sodium Gastro-Resistant / Enteric-Coated Tablets (10 mg / 20 mg), manufactured in WHO–GMP certified, high-precision modified-release oral solid dosage facilities. This “Next-Generation Proton Pump Inhibitor (PPI)” is a highly lucrative, premium export to gastroenterology centers, internal medicine clinics, retail pharmacy networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, rapid-onset intervention for severe Gastroesophageal Reflux Disease (GERD) and active Peptic Ulcer Disease.

Product Overview

This highly advanced formulation contains Rabeprazole Sodium, a potent, ultra-fast-acting acid suppressor that fundamentally outperforms older PPIs by delivering faster clinical relief and highly predictable pharmacokinetics.

The “Rapid-Onset & CYP-Independent” Specialist:

• Mechanism 1 (The Rapid Proton Pump Blockade): Rabeprazole has a higher pKa (around 5.0) than other PPIs. This means it activates much more rapidly in the acidic environment of the parietal cells. It irreversibly binds to the H+/K+ ATPase enzyme (the proton pump), violently shutting down the final step of gastric acid secretion. This provides significantly faster relief of severe heartburn and esophageal burning compared to Omeprazole or Pantoprazole.
• Mechanism 2 (The “Predictable Metabolism” Advantage – CRITICAL): Older PPIs rely heavily on the CYP2C19 liver enzyme for metabolism. Because genetics vary wildly globally, some patients process Omeprazole too quickly (getting no relief) and some too slowly (risking toxicity). Rabeprazole is primarily metabolized via a non-enzymatic pathway. This makes it a “CYP-independent” PPI, guaranteeing reliable, potent acid suppression in every single patient, regardless of their genetic makeup.
• H. Pylori Eradication: Rabeprazole exhibits intrinsic antibacterial activity against Helicobacter pylori. When combined with Amoxicillin and Clarithromycin, it provides the ultimate, high-efficacy eradication protocol for severe gastric ulcers.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Gastroenterology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Dual-Barrier Enteric Engineering (CRITICAL COMPLIANCE): Rabeprazole is violently destroyed by stomach acid. If the tablet dissolves in the stomach, the drug is ruined before it can be absorbed. Our facilities utilize advanced Fluid Bed Coating technology. First, the Rabeprazole core is blended with alkaline stabilizers (like Magnesium Oxide) to prevent internal self-degradation. Second, a highly specialized, pH-dependent Methacrylic Acid Copolymer (Enteric Coat) is applied. This guarantees the tablet survives the harsh acid of the stomach and releases 100% of the active API only when it reaches the safe, alkaline environment of the small intestine.

Therapeutic Indications (Human Use)

Indicated for the targeted, rapid healing of acid-related gastrointestinal mucosal damage:

• Erosive Esophagitis (GERD): Short-term treatment and symptom relief of active erosive or ulcerative gastroesophageal reflux disease.
• Active Peptic Ulcers: Short-term treatment of active duodenal and benign gastric ulcers.
• H. Pylori Eradication: In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori to reduce the risk of duodenal ulcer recurrence.
• Zollinger-Ellison Syndrome: Long-term treatment of pathological hypersecretory conditions.

Dosage & Administration

Recommended Dosage (Strictly as per Gastroenterologist Guidelines):

• Standard Adult Dosing: 20 mg taken orally once daily for 4 to 8 weeks for acute healing. 10 mg or 20 mg daily for long-term maintenance.
• Administration (THE INTACT TABLET RULE): Tablets MUST be swallowed completely whole with a glass of water, ideally 30 minutes before breakfast. They must never be chewed, crushed, or divided. Breaking the tablet physically destroys the enteric coating, exposing the Rabeprazole to stomach acid and causing complete therapeutic failure.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• Clostridium difficile-Associated Diarrhea (CDAD): By drastically lowering stomach acid (which normally kills ingested bacteria), PPIs increase the risk of severe intestinal infections, particularly C. difficile. Patients must report persistent, severe, watery diarrhea immediately.
• Bone Fracture Risk: Long-term, high-dose use of PPIs (over 1 year) has been associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine, due to severely reduced calcium absorption.
• Severe Hypomagnesemia: Prolonged use can cause a massive drop in blood magnesium levels, leading to severe muscle spasms, tremors, and fatal cardiac arrhythmias. Magnesium levels should be monitored in patients on long-term therapy.
• Vitamin B12 Deficiency: Daily treatment with any acid-suppressing medication over a long period of time (e.g., longer than 3 years) may lead to malabsorption of cyanocobalamin (Vitamin B12).

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Gastroenterological and Enteric-Coated Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for GI clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.