Description

Olmesartan Medoxomil Film-Coated Tablets (20 mg / 40 mg)

Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, anti-hypertensive, and renoprotective therapeutics. We provide ultra-high-purity, kinetically stabilized Olmesartan Medoxomil Film-Coated Tablets (20 mg / 40 mg), manufactured in WHO–GMP certified, strictly humidity-controlled oral solid dosage facilities. This “Next-Generation Angiotensin II Receptor Blocker (ARB)” is a premium, highly lucrative export to cardiology centers, internal medicine clinics, retail pharmacy networks, and government health ministries in LATAM, the CIS, Africa, and Southeast Asia, serving as the globally mandated, high-efficacy intervention for severe Essential Hypertension and cardiovascular risk reduction.

Product Overview

This highly advanced formulation utilizes a sophisticated ester prodrug design to bypass gastric destruction, delivering an incredibly potent, long-lasting blockade of the body’s primary blood-pressure-raising hormone.

The “AT1 Receptor Tight-Binding” Specialist:

• Mechanism 1 (The Complete RAAS Blockade): Angiotensin II is a powerful chemical that forcefully constricts blood vessels and triggers the release of aldosterone (causing the body to retain salt and water). Olmesartan acts as a highly selective antagonist at the AT1 receptor subtype. It binds so tightly to these receptors that it completely blocks Angiotensin II from attaching. This physically relaxes the arterial walls, dropping peripheral vascular resistance and profoundly reducing the workload on a failing, hypertensive heart.
• Mechanism 2 (The Prodrug & 24-Hour Superiority): Unlike older ARBs, Olmesartan is administered as a prodrug (Olmesartan Medoxomil). During absorption from the gastrointestinal tract, enzymes in the gut wall rapidly hydrolyze (cleave) the medoxomil ester, releasing the active, highly potent Olmesartan directly into the blood. Its unique chemical structure allows it to bind to the AT1 receptor with far greater affinity than Losartan, guaranteeing smooth, unbroken blood pressure control for a full 24 hours with just a single dose.
• The Diabetic Renoprotective Shield: Beyond lowering blood pressure, Olmesartan drastically reduces the pressure inside the delicate filtering units of the kidneys (the glomeruli). This aggressively slows the progression of diabetic nephropathy, making it a life-saving, first-line therapy for hypertensive patients suffering from Type 2 Diabetes.

Product Composition & Strength

We supply this product as a Precision-Blended Film-Coated Tablet, packed exclusively in highly secure, moisture-resistant Alu-Alu blister strips to ensure the absolute chemical stability of the highly volatile ester prodrug.

*Pack Sizes: 10×10 Alu-Alu Blisters or 3×10 Unit-Dose Blisters (Optimized specifically for strict 30-day chronic cardiology dispensing regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Cardiology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Hydrolytic Degradation Control Engineering (CRITICAL COMPLIANCE): Manufacturing an ester prodrug requires elite environmental control. If water is introduced during wet granulation, the Olmesartan will chemically cleave in the factory before it ever reaches the patient. Our facilities completely bypass traditional wet granulation, utilizing advanced dry-blending and roller compaction under strict, ultra-low humidity environmental suites (RH < 30%). This guarantees the prodrug remains 100% structurally intact, ensuring flawless bioavailability upon swallowing.

Therapeutic Indications (Human Use)

Indicated for the comprehensive, multi-pathway management of severe cardiovascular disease:

• Essential Hypertension: Treatment of high blood pressure in adults and children (aged 6 years and older). May be used as monotherapy or in combination with other antihypertensive agents (like Amlodipine or Hydrochlorothiazide).

Dosage & Administration

Recommended Dosage (Strictly as per Cardiologist Guidelines):

• Standard Adult Dosing: Usually initiated at 20 mg once daily. For patients requiring further reduction in blood pressure after 2 weeks of therapy, the dose may be increased to 40 mg.
• Administration: Can be administered with or without food. Tablets must be swallowed whole.
• Volume-Depleted Patients: In patients with severe volume depletion (e.g., those treated with high-dose diuretics), therapy should be initiated under close medical supervision due to the massive risk of sudden, severe symptomatic hypotension.

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX WARNING (Fetal Toxicity): When pregnancy is detected, discontinue this medication immediately. Drugs that act directly on the renin-angiotensin system can cause profound injury, massive malformations, and death to the developing fetus.
• Sprue-Like Enteropathy (OLMESARTAN-SPECIFIC SEVERE WARNING): Unlike any other ARB, Olmesartan can cause a severe, life-threatening gastrointestinal condition called Sprue-like enteropathy. Symptoms include severe, chronic diarrhea with substantial weight loss. This can develop months or even years after starting the drug. If a patient develops these symptoms and no other cause is found, Olmesartan MUST be discontinued immediately.
• Hyperkalemia: ARBs force the body to retain potassium. Concurrent use of potassium-sparing diuretics (like Spironolactone) or potassium supplements can lead to fatal cardiac arrhythmias.
• Renal Impairment & Bilateral Renal Artery Stenosis: In patients whose renal function depends heavily on the RAAS system (e.g., severe congestive heart failure), treating with ARBs can cause acute, catastrophic kidney failure.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular Formulations. Whether you are looking for a reliable Government Tender Supplier for cardiology clinics in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely, secure delivery of highly stable, WHO-GMP certified products.