Methimazole Tablets

Description

Methimazole Tablets (5 mg / 10 mg)

Healthy Inc is a specialized global supplier and exporter of advanced endocrinology, internal medicine, and targeted hormonal therapeutics. We provide ultra-high-purity, kinetically optimized Methimazole Tablets, manufactured in WHO–GMP certified, high-precision specialized oral solid dosage facilities. This “Antithyroid Thionamide” is a massive-volume strategic export to endocrinology hospitals, metabolic centers, and government health ministries, serving as the globally preferred first-line intervention for Hyperthyroidism and Graves’ Disease.

Product Overview

This formulation operates as a “Synthesis Interrupter.” Methimazole does not destroy existing thyroid hormones; instead, it physically stops the thyroid gland from “building” new ones.

• Mechanism 1 (Thyroid Peroxidase Inhibition): Methimazole inhibits the enzyme Thyroid Peroxidase (TPO). This enzyme is the primary “engine” that attaches iodine to the protein thyroglobulin to create T3 and T4 hormones.

• Mechanism 2 (Iodination Blockade): By blocking TPO, the drug physically prevents the organification of iodine. Without iodine attachment, the production of thyroxine ($T_4$) and triiodothyronine ($T_3$) effectively halts.

• Mechanism 3 (Pre-Surgical Stabilization): It is frequently used to achieve a “euthyroid” (normal hormone) state before patients undergo thyroid surgery or radioactive iodine treatment, significantly reducing the risk of a “thyroid storm.”

Product Composition & Strength

We supply this product in standardized strengths to allow for the precise titration required to balance thyroid levels.

Technical & Logistics Specifications

• HS Code: 3004.90.39 (Medicaments containing hormones or other products – Antithyroid)

• CAS Number: 60-56-0 (Methimazole / Thiamazole)

• Dosage Form: Uncoated or Film-Coated Tablet

• Packaging: Alu-Alu or Alu-PVC Blisters. Protects the sensitive API from environmental humidity; our high-barrier packaging ensures 24-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Hormonal Precision: Our manufacturing process focuses on absolute chemical stability, ensuring the Thionamide derivative remains potent, providing the predictable T3/T4 reduction required for chronic endocrine management.

• Dedicated Production Blocks: We utilize Segregated Non-Beta-Lactam Production Facilities to ensure zero cross-contamination, meeting the strictest international regulatory standards for hormonal medications.

Primary Indications

• Endocrinology: Treatment of Hyperthyroidism (Overactive Thyroid).

• Immunology: Long-term management of Graves’ Disease.

• Pre-Operative Care: Preparation for thyroidectomy or radioactive iodine therapy in hyperthyroid patients.

Dosage & Administration

• Mild Hyperthyroidism: Initially 15 mg daily (split into three doses).

• Severe Hyperthyroidism: 30 mg to 60 mg daily until hormone levels stabilize.

• Maintenance: Usually 5 mg to 15 mg daily.

• Administration: Can be taken with or without food, but should be taken consistently at the same time every day.

Safety Warning: Agranulocytosis. Methimazole can cause a sudden, severe drop in white blood cells. MANDATORY: Patients must report any sore throat or fever immediately. Hepatotoxicity: Monitor Liver Function Tests (LFTs) for signs of jaundice or cholestasis. Pregnancy: Methimazole is generally avoided in the first trimester (Propylthiouracil is preferred) due to rare birth defects like Aplasia Cutis.

Global Export & Contract Manufacturing

Healthy Inc is a premier Endocrinology Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-volume Antithyroid therapeutics. Whether you are a Metabolic Health Center in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.