Description
Lamivudine, Zidovudine & Nevirapine Tablets
Healthy Inc is a specialized global supplier and exporter of life-saving Antiretroviral (ARV) therapies. We provide high-stability Triple Fixed-Dose Combination (FDC) Tablets, sourced from WHO–GMP certified solid dosage facilities. This “All-in-One” maintenance therapy is a top export to National AIDS Control Programs, NGO humanitarian missions, and Ministry of Health tenders in Africa (Sub-Saharan), LATAM, and Southeast Asia, simplifying HIV management by reducing pill burden and improving adherence.
Product Overview
This formulation combines two Nucleoside Reverse Transcriptase Inhibitors (NRTIs) with one Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) to effectively suppress viral replication.
The “Triple Shield” Specialist:
- Lamivudine (3TC) & Zidovudine (AZT): These NRTIs act as “false building blocks.” They mimic the natural nucleosides used by the virus to build DNA. When the HIV enzyme Reverse Transcriptase attempts to use them, they cause immediate chain termination, stopping the virus from converting its RNA into DNA.
- Nevirapine (NVP): An NNRTI that binds directly to a hydrophobic pocket on the Reverse Transcriptase enzyme. This binding induces a shape change (conformational change) in the enzyme, locking it in an inactive state and preventing it from functioning.
- Synergy: By attacking the same enzyme (Reverse Transcriptase) via two different mechanisms (competitive and non-competitive inhibition), this combination creates a robust barrier against viral mutation and resistance.
Product Composition & Strength
We supply this product as Film Coated Tablets (often White or Off-White). This FDC is designed for patients who have successfully completed the Nevirapine “lead-in” phase.
| Active Ingredient | Strength (Standard) | Class |
|---|---|---|
| Lamivudine USP/BP | 150 mg | NRTI (Cytidine Analog) |
| Zidovudine USP/BP | 300 mg | NRTI (Thymidine Analog) |
| Nevirapine USP/BP | 200 mg | NNRTI |
| Excipients | Q.S. | Microcrystalline Cellulose / Sodium Starch Glycolate |
*Pack Sizes: Blister packs of 10s, 60s (Monthly Bottle for Twice Daily dosing), or Bulk HDPE Jars of 1000s (Program Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Medicaments containing antivirals) |
| Dosage Form | Tablet (Film Coated) |
| Packaging | High-Density Polyethylene (HDPE) Bottle with Desiccant |
| Storage | Store below 30°C. Protect from Light and Moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Dissolution Enhancement: Nevirapine is hydrophobic (water-repelling) and difficult to dissolve. We use specialized wet granulation techniques with surfactants to ensure immediate release and consistent bioavailability, matching innovator pharmacokinetics.
- Stability: Zidovudine is light-sensitive and Nevirapine is moisture-sensitive. Our HDPE packaging includes heavy-grammage silica gel sachets and induction sealing to guarantee stability in tropical climates (Zone IVb).
Therapeutic Indications (Human Use)
Indicated for the treatment of HIV-1 infection:
- Maintenance Therapy: For adults and children (weighing >25 kg) whose HIV-1 infection is controlled and who have shown adequate tolerance to Nevirapine during the initial 2-week lead-in phase.
- Note: Not recommended for initiation of therapy (due to Nevirapine lead-in requirement) unless supervised strictly.
Dosage & Administration
Recommended Dosage (Strictly as per HIV Specialist):
- Route: Oral.
- Adults & Adolescents (>30 kg): One tablet taken twice daily (every 12 hours).
- Administration: Can be taken with or without food.
- Missed Dose: Adherence is critical. If a dose is missed, viral resistance can develop rapidly.
Safety Warnings:
- Skin Rash (SJS/TEN): Nevirapine can cause severe, life-threatening skin reactions (Stevens-Johnson Syndrome). Patients must report any rash immediately.
- Hepatotoxicity: Severe liver toxicity can occur, especially in women with high CD4 counts (>250 cells/mm³). Frequent liver monitoring is required.
- Bone Marrow Suppression: Zidovudine causes Anemia (low red blood cells) and Neutropenia. Regular blood counts are mandatory.
- Lactic Acidosis: A rare but serious complication of NRTIs (Zidovudine/Lamivudine).
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
