Description
Isosorbide Mononitrate Tablets (20 mg)
Healthy Inc is a specialized global supplier and exporter of organic nitrates for chronic cardiac care. We provide high-stability Isosorbide Mononitrate 20 mg Tablets, sourced from WHO–GMP certified solid dosage facilities. This essential vasodilator is a top export to cardiology units, geriatric clinics, and government health departments in Africa, LATAM, and Southeast Asia, serving as a primary therapy for the long-term prophylaxis of angina pectoris.
Product Overview
This formulation contains Isosorbide Mononitrate, the major active metabolite of isosorbide dinitrate. Unlike the dinitrate form, the mononitrate is 100% bioavailable and does not undergo first-pass hepatic metabolism, providing a more predictable clinical response.
The “Venous Dilator” Specialist:
- Mechanism of Action: Isosorbide Mononitrate relaxes vascular smooth muscle by stimulating intracellular cyclic guanosine monophosphate (cGMP). It acts primarily as a venous dilator, reducing the left ventricular end-diastolic pressure (preload). To a lesser extent, it also dilates arterial vessels, reducing systemic vascular resistance (afterload).
- Cardiac Oxygen Balance: By reducing the workload of the heart, it lowers myocardial oxygen demand. Simultaneously, it promotes the redistribution of blood flow to ischemic areas of the myocardium, helping to prevent the onset of chest pain.
- Metabolic Advantage: Because it is already an active metabolite, it offers consistent plasma levels and is suitable for patients with varying degrees of liver function.
Product Composition & Strength
We supply this product as Immediate Release Tablets (20 mg). We also offer Extended Release (ER/SR) variants for once-daily dosing through our contract manufacturing division.
| Active Ingredient | Strength (Standard) | Therapeutic Role | |
|---|---|---|---|
| Isosorbide Mononitrate BP/USP | 20 mg | Organic Nitrate / Vasodilator | |
| Excipients | Q.S. | Microcrystalline Cellulose / Lactose | Stabilizing Matrix |
*Pack Sizes: Blister packs of 10s (Box of 10×10) or 30s. Bulk supplies available for Ministry of Health tenders.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Cardiovascular Medicaments) |
| Dosage Form | Tablet (Uncoated / Film Coated) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Protect from moisture and excessive heat. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Nitrate Stability Management: Organic nitrates can be volatile and sensitive to environmental conditions. Our manufacturing process uses controlled-temperature granulation to ensure the API remains stable within the tablet matrix throughout its shelf life.
- Dose Uniformity: We maintain strict analytical controls to ensure that each tablet delivers the exact 20 mg dose required to maintain the “Nitrate-Free Interval,” which is critical for preventing pharmacological tolerance.
Therapeutic Indications (Human Use)
Indicated for the chronic management of coronary artery disease:
- Angina Pectoris: Prophylaxis (prevention) of angina pectoris.
- Heart Failure: Used as adjunctive therapy in chronic heart failure management in combination with other agents.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Standard Dose: 20 mg taken twice daily, usually 7 to 8 hours apart (e.g., 8 AM and 3 PM).
- Nitrate-Free Interval (CRITICAL): To prevent Nitrate Tolerance (where the drug stops working), the doses should be timed to allow for a period of low nitrate levels (usually 10-12 hours) every day, typically during sleep.
Safety Warnings:
- Drug Interactions: CONTRAINDICATION: Never take with PDE-5 inhibitors (e.g., Sildenafil, Tadalafil) as this can cause a life-threatening drop in blood pressure.
- Nitrate Headache: A common side effect due to vasodilation; usually diminishes as treatment continues.
- Orthostatic Hypotension: Patients should be advised to rise slowly from a sitting or lying position to avoid dizziness.
- Not for Acute Attacks: This is a maintenance medication and will not work fast enough to stop an acute angina attack.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
