Description
Glimepiride & Metformin Hydrochloride Tablets
Healthy Inc is a specialized global supplier and exporter of high-efficacy oral hypoglycemic combinations. We provide premium Glimepiride & Metformin Hydrochloride Tablets, sourced from WHO–GMP certified solid dosage facilities. This synergistic “Dual-Action” anti-diabetic therapy is a primary export to endocrinology clinics, metabolic centers, and government health departments in Africa, LATAM, and Southeast Asia, serving as a second-line treatment for Type 2 Diabetes Mellitus when monotherapy is insufficient.
Product Overview
This formulation combines a second-generation sulfonylurea with a biguanide to address the two primary defects of Type 2 Diabetes: insulin deficiency and insulin resistance.
The “Metabolic Synergy” Specialist:
- Glimepiride (The Insulin Secretagogue): Acts by stimulating the Beta cells of the pancreas to release more insulin. It binds to the sulfonylurea receptor (SUR1) on the pancreatic cell membrane, closing ATP-sensitive potassium channels and triggering calcium influx, which leads to insulin exocytosis.
- Metformin HCl (The Insulin Sensitizer): Works primarily by reducing hepatic glucose production (gluconeogenesis) and increasing peripheral glucose uptake and utilization in the muscles. It activates AMP-activated protein kinase (AMPK), improving insulin sensitivity without causing hypoglycemia when used alone.
- Combined Efficacy: This fixed-dose combination (FDC) provides superior glycemic control (HbA1c reduction) compared to high-dose monotherapy, while promoting better patient compliance through a reduced pill burden.
Product Composition & Strength
We supply this product as Bilayered Tablets or Film Coated Tablets. The bilayered technology is often used to manage the different release profiles and physical characteristics of the two APIs.
| Active Ingredient | Strength (Standard) | Therapeutic Role | |
|---|---|---|---|
| Glimepiride USP/BP/IP | 1 mg / 2 mg | Sulfonylurea (Insulin Secretagogue) | |
| Metformin HCl USP/BP/IP | 500 mg / 1000 mg | Biguanide (Insulin Sensitizer) | |
| Excipients | Q.S. | Povidone / Magnesium Stearate | Stabilizing Core Matrix |
*Available in Immediate Release (IR) and Sustained/Extended Release (SR/ER) Metformin variants.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Anti-Diabetic Medicaments) |
| Dosage Form | Tablet (Bilayered / Film Coated) |
| Packaging | Blister packs of 10s or 15s (Alu-Alu or PVC-PVdC/Alu) |
| Storage | Store below 25°C. Protect from light and moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Bilayer Compression Expertise: Since Metformin requires a high dose (500mg+) and Glimepiride a micro-dose (1-2mg), we utilize Bilayer Tableting Machines to prevent cross-interaction and ensure precise content uniformity for the low-dose Glimepiride component.
- SR/ER Technology: For our Sustained Release variants, we use a hydrophilic matrix system that ensures Metformin is released slowly over 12-24 hours, significantly reducing gastrointestinal side effects.
Therapeutic Indications (Human Use)
Indicated for the management of Type 2 Diabetes Mellitus:
- Glycemic Control: As an adjunct to diet and exercise to improve blood sugar control in adults.
- Combination Therapy: For patients whose blood glucose is not adequately controlled on Metformin or Glimepiride monotherapy.
Dosage & Administration
Recommended Dosage (Strictly as per Endocrinologist):
- Route: Oral.
- Starting Dose: Usually one tablet of the lowest strength (1mg/500mg) once daily.
- Administration: Must be taken with breakfast or the first main meal of the day. Taking it with food reduces gastrointestinal upset from Metformin and ensures Glimepiride covers the post-prandial glucose spike.
Safety Warnings:
- Hypoglycemia: Glimepiride can cause low blood sugar. Patients should carry a source of glucose.
- Lactic Acidosis: WARNING: A rare but serious metabolic complication of Metformin, especially in patients with significant renal impairment.
- Renal Monitoring: Serum creatinine and eGFR should be checked before starting and at least annually during treatment.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
