Description

Cefixime Capsules

Healthy Inc is a specialized global supplier and exporter of advanced broad-spectrum beta-lactam antimicrobials. We provide high-purity Cefixime Capsules (400 mg), manufactured in WHO–GMP certified, completely dedicated cephalosporin oral solid dosage facilities. This “Third-Generation Cephalosporin” is a massive-volume, mandatory export to infectious disease clinics, outpatient centers, sexual health clinics, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the definitive oral intervention for Typhoid Fever, uncomplicated Gonorrhea, and severe respiratory/urinary tract infections.

Product Overview

This formulation contains Cefixime (as Cefixime Trihydrate), a highly stable, orally active, third-generation cephalosporin antibiotic.

The “Beta-Lactamase Resistant” Specialist:

• Mechanism (Cell Wall Synthesis Blockade): Like all beta-lactams, Cefixime is bactericidal. It effortlessly penetrates the bacterial cell envelope and binds with exceptionally high affinity to specific Penicillin-Binding Proteins (PBPs), particularly PBP-3 and PBP-1a. It halts the final stage of peptidoglycan cross-linking, physically weakening the cell wall until osmotic pressure causes the bacteria to burst (lyse).
• Third-Generation Gram-Negative Dominance: Unlike first-generation cephalosporins (like Cephalexin), Cefixime exhibits radically enhanced activity against severe Gram-negative pathogens, including Salmonella typhi, Shigella, Neisseria gonorrhoeae, and Haemophilus influenzae.
• Beta-Lactamase Stability: A key clinical advantage of Cefixime is its extreme stability in the presence of beta-lactamase enzymes produced by resistant bacteria. This allows it to effectively destroy pathogens that have evolved to rapidly degrade standard penicillins and earlier cephalosporins.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in moisture-resistant Alu-Alu blister strips to preserve the trihydrate API structure.

*Pack Sizes: 1×5 or 10×10 Alu-Alu Blisters. (Alu-Alu is strongly recommended to protect the trihydrate form from extreme tropical humidity).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Outpatient Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Dedicated Cephalosporin Isolation: Regulatory guidelines strictly prohibit manufacturing cephalosporins in the same facilities as penicillins or general non-antibiotic drugs. Our Cefixime is processed in a 100% isolated manufacturing block featuring independent HVAC units and dedicated machinery to completely eliminate the risk of fatal anaphylactic cross-contamination.
• Optimized Oral Bioavailability: Cefixime Trihydrate has inherently slow absorption characteristics. Our formulation engineers utilize advanced superdisintegrants to ensure immediate capsule rupture, maximizing GI absorption to achieve reliable peak serum concentrations within 2 to 6 hours.

Therapeutic Indications (Human Use)

Indicated for the treatment of severe, susceptible bacterial infections:

• Uncomplicated Gonorrhea: Cervical/urethral infections caused by Neisseria gonorrhoeae (often given as a single 400mg dose).
• Enteric Infections: Typhoid fever and severe shigellosis, particularly when fluoroquinolone resistance is present.
• Urinary Tract Infections (UTIs): Uncomplicated UTIs caused by E. coli and Proteus mirabilis.
• Respiratory Tract Infections: Acute exacerbations of chronic bronchitis, otitis media, and pharyngitis/tonsillitis caused by S. pneumoniae or H. influenzae.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Administration: Taken orally, with or without food. (Taking it with food does not significantly alter total absorption but can minimize gastrointestinal upset).
• Standard Adult Dose: 400 mg daily. This may be administered as a single 400 mg capsule once daily, or as a 200 mg dose every 12 hours (depending on capsule availability/strength).
• Uncomplicated Gonorrhea: A single 400 mg oral dose.
• Renal Impairment: Because Cefixime is excreted primarily unchanged by the kidneys, the dose must be reduced in patients with severe renal impairment (creatinine clearance < 20 mL/min).

Safety Warnings (CRITICAL):

• Penicillin Cross-Reactivity: Cephalosporins share structural similarities with penicillins. Approximately 5% to 10% of patients with a documented Penicillin allergy will experience a hypersensitivity reaction to Cefixime. It is strictly contraindicated in patients who have a history of Penicillin-induced anaphylaxis.
• Pseudomembranous Colitis: Can drastically alter normal gut flora, frequently leading to the overgrowth of Clostridioides difficile. This can cause severe, potentially fatal pseudomembranous colitis (CDAD). If severe diarrhea occurs, the drug must be discontinued.
• Renal Toxicity Caution: While less nephrotoxic than aminoglycosides, caution should be exercised when co-administered with other nephrotoxic drugs or powerful diuretics.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Dedicated Cephalosporin Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.