Description

Carboplatin Injection

Healthy Inc is a specialized global supplier and exporter of advanced platinum-based antineoplastic agents. We provide high-purity Carboplatin Injection (150 mg / 450 mg), sourced from WHO–GMP certified Cytotoxic injectable facilities. This “Second-Generation Platinum” is a top export to oncology centers, chemotherapy daycare units, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the cornerstone therapy for ovarian and lung cancers with a significantly better safety profile than Cisplatin.

Product Overview

This formulation contains Carboplatin, a platinum coordination complex that acts as an alkylating agent.

The “Less Toxic” Specialist:

• Mechanism (DNA Cross-linking): Like Cisplatin, Carboplatin enters the cancer cell and undergoes aquation. It binds to DNA, forming inter-strand and intra-strand cross-links (adducts). This “kinks” the DNA structure, inhibiting replication and transcription, which triggers apoptosis (cell death).
• Safety Advantage: Carboplatin was developed specifically to reduce the severe side effects of Cisplatin. It causes significantly less nephrotoxicity (kidney damage), ototoxicity (hearing loss), and nausea/vomiting, making it suitable for outpatient therapy and elderly patients.
• Dosing Precision (The Calvert Formula): Unlike most chemo drugs dosed by body surface area (BSA), Carboplatin is unique. It is dosed based on the patient’s kidney function (GFR) to achieve a target “Area Under the Curve” (AUC), ensuring maximum efficacy with minimal toxicity.

Product Composition & Strength

We supply this product as a Sterile Liquid Concentrate in glass vials. It is ready to dilute.

*Pack Sizes: Single Vial Box with protective Cytotoxic shrink-wrapping.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Oncology Containment: Manufactured in a dedicated Cytotoxic facility using isolator technology to prevent cross-contamination and protect operators.
• Aluminum-Free Processing: Carboplatin reacts with aluminum to form a precipitate and lose potency. Our manufacturing equipment and needles are strictly aluminum-free to ensure product stability.

Therapeutic Indications (Human Use)

Indicated for the palliative treatment of:

• Ovarian Carcinoma: The global standard of care (often combined with Paclitaxel) for advanced epithelial ovarian cancer.
• Small Cell Lung Cancer (SCLC): Used in combination with Etoposide.
• Head & Neck Cancer: For patients unable to tolerate Cisplatin.
• Advanced Endometrial Cancer: Palliative therapy.

Dosage & Administration

Recommended Dosage (Strictly as per Oncologist):

• Route: Intravenous (IV) Infusion ONLY. (Over 15-60 minutes).
• Dosing (Calvert Formula):Total Dose (mg) = (Target AUC) × (GFR + 25)*Target AUC is usually 4-6 for previously treated patients and 5-7 for untreated patients.
• Dilution: Dilute in 5% Dextrose or 0.9% Sodium Chloride to a concentration of 0.5 mg/ml.
• Precaution: Do not use needles or IV sets containing aluminum parts.

Safety Warnings (CRITICAL):

• Myelosuppression (Dose-Limiting Toxicity): Unlike Cisplatin (kidney), Carboplatin’s main side effect is Thrombocytopenia (low platelets) and Leukopenia. Bone marrow function must be monitored closely.
• Anaphylaxis: Hypersensitivity reactions can occur, usually after several courses of therapy.
• Pregnancy: Category D. Can cause fetal harm.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.