Caffeine Citrate Solution

Description

Caffeine Citrate Oral / Injectable Solution

Healthy Inc is a specialized global supplier and exporter of advanced neonatology, critical care, and pediatric therapeutics. We provide ultra-high-purity, kinetically stabilized Caffeine Citrate Solution, manufactured in WHO–GMP certified, high-precision sterile facilities. This “Methylxanthine Respiratory Stimulant” is a critical strategic export to NICUs (Neonatal Intensive Care Units), specialized pediatric hospitals, and government health ministries, serving as the globally mandated intervention for the short-term treatment of idiopathic apnea of prematurity in infants.

Product Overview

This formulation operates as a “Neurological Drive Stimulator.” It physically crosses the blood-brain barrier to target the respiratory control centers, ensuring the premature infant maintains a consistent, physical breathing rhythm.

• Mechanism 1 (Adenosine Receptor Antagonism): Caffeine physically blocks Adenosine A1 and A2A receptors. Since adenosine normally inhibits neuronal activity, blocking it physically increases the firing rate of the respiratory neurons.

• Mechanism 2 (Medullary Stimulant): It physically increases the sensitivity of the Medullary Respiratory Center to carbon dioxide ($CO_{2}$), forcing the body to breathe more consistently.

• Mechanism 3 (Diaphragmatic Strength): It physically enhances the contractility of the diaphragm and increases metabolic rate, reducing the physical effort required for a neonate to ventilate the lungs.

Product Composition & Strength

We supply this product as a Sterile, Preservative-Free Aqueous Solution, optimized for both oral administration and intravenous infusion.

Technical & Logistics Specifications

• HS Code: 3004.43.00 (Medicaments containing Alkaloids or their derivatives)

• CAS Number: 69-22-7 (Caffeine Citrate)

• Dosage Form: Sterile Solution (Oral/Injectable)

• Packaging: 3ml / 5ml Clear Glass Vials or Ampoules. Our specialized sterile packaging ensures 24-month stability in controlled environments.

Manufacturing Authority & Compliance

• Aseptic Filling Excellence: Our manufacturing process utilizes Class 100 (ISO 5) Aseptic Filling Lines. Given that this product is for premature neonates with underdeveloped immune systems, 100% sterility is our absolute physical priority.

• Preservative-Free Guarantee: Our solution is 100% free from preservatives (like Benzyl Alcohol), which are physically toxic to newborns, meeting the strictest international NICU safety standards.

• Precision pH Buffering: We utilize Advanced Citrate Buffering to ensure the solution is physically stable and non-irritating to the neonatal gastric mucosa or venous lining.

Primary Indications

• Neonatology: Treatment of Apnea of Prematurity in infants between 28 and 32 weeks of gestational age.

• Critical Care: Facilitating the Extubation (removal from a ventilator) of premature infants by maintaining respiratory drive.

Dosage & Administration

• Loading Dose: Typically 20 mg/kg (1 mL/kg) administered via slow IV infusion or orally.

• Maintenance Dose: Typically 5 mg/kg (0.25 mL/kg) administered once every 24 hours.

• Administration: Can be given physically via an orogastric tube or as a slow IV infusion. Monitoring of serum caffeine levels is physically recommended for long-term use.

Safety Warning: Preservative-Free. Cardiac Warning: Monitor for tachycardia (high heart rate) and cardiac arrhythmias. Metabolic Note: May cause increased urine output or jitteriness. Contraindication: Do not use if known hypersensitivity to xanthine derivatives exists.

Global Export & Contract Manufacturing

Healthy Inc is a premier Neonatology and Critical Care Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-precision sterile liquids. Whether you are a Specialized Children’s Hospital in the Middle East or a B2B Pharma Marketplace partner in Europe, the CIS, or SE Asia, we ensure secure, WHO-GMP compliant delivery.