Description
Bisoprolol Fumarate Tablets
Healthy Inc is a specialized global supplier and exporter of highly cardioselective beta-blockers. We provide high-purity Bisoprolol Fumarate Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Heart-Specific” agent is a top export to cardiology institutes, hypertension clinics, and government health formularies in Africa, LATAM, and Southeast Asia, recognized for its superior selectivity and role as a cornerstone therapy in chronic heart failure management.
Product Overview
This formulation contains Bisoprolol Fumarate, a synthetic beta-1 selective adrenoceptor blocking agent.
The “Cardio-Specific” Specialist:
- High Selectivity: Bisoprolol exhibits the highest affinity for Beta-1 receptors (heart) compared to Beta-2 receptors (lungs/vessels) among clinically available beta-blockers. This “Cardioselectivity” minimizes side effects like bronchoconstriction and metabolic disturbances, making it safer for patients with mild asthma or diabetes compared to non-selective agents (like Propranolol).
- Mechanism: It reduces the heart rate (negative chronotropy) and the force of contraction (negative inotropy) by blocking catecholamine action. It also suppresses Renin release from the kidneys, further lowering blood pressure.
- Heart Failure Survival: Along with Carvedilol and Metoprolol Succinate, Bisoprolol is one of the few beta-blockers proven (CIBIS Trials) to reduce mortality in stable chronic heart failure.
- 24-Hour Control: With a long elimination half-life (10–12 hours), a single daily dose provides effective blood pressure control for a full 24 hours.
Product Composition & Strength
We supply this product as Film Coated Tablets (distinctively shaped/scored). The low-dose range is critical for the “Start Low, Go Slow” titration required in heart failure.
| Active Ingredient | Strength (Standard) | Shape/Color | Primary Role |
|---|---|---|---|
| Bisoprolol Fumarate USP/BP | 2.5 mg | White (Scored) | Heart Failure Initiation |
| Bisoprolol Fumarate USP/BP | 5 mg | Yellow/Pink (Scored) | Standard Hypertension |
| Bisoprolol Fumarate USP/BP | 10 mg | Orange/White | High Dose Maintenance |
| Excipients | Q.S. | Microcrystalline Cellulose / Hypromellose | Filler / Coating |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 14s, 28s, 30s (Calendar Pack), or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Film Coated Tablet (Oral) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Protect from moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Dose Uniformity: The 2.5 mg tablet contains a very small amount of active drug. We utilize precision geometric blending and high-shear granulation to ensuring excellent content uniformity (RSD < 2%), ensuring no tablet is sub-potent during critical heart failure titration.
- Dissolution: Our formulation is engineered to release the drug consistently independent of pH, ensuring reliable absorption whether taken with food or on an empty stomach.
Therapeutic Indications (Human Use)
Indicated for the management of cardiovascular disorders:
- Hypertension: Monotherapy or in combination with diuretics/ACE inhibitors/calcium channel blockers.
- Chronic Heart Failure (CHF): Treatment of stable chronic heart failure with reduced systolic left ventricular function (in addition to ACE inhibitors, and diuretics).
- Angina Pectoris: Long-term prophylaxis of chest pain episodes.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Hypertension/Angina: Usually 5 mg once daily. May be increased to 10 mg or 20 mg if needed.
- Chronic Heart Failure (Strict Protocol):
- Start: 1.25 mg once daily for 1 week.
- Increase to 2.5 mg, then 3.75 mg, then 5 mg, etc., at intervals of 1–4 weeks based on tolerability.
- Target Maintenance Dose: 10 mg once daily.
- Timing: Taken once daily in the morning, with or without food. Swallow whole; do not chew.
Safety Warnings:
- Abrupt Cessation (Black Box): Do not stop suddenly. This can cause “Rebound Hypertension,” severe angina, or heart attack. Taper the dose over 1–2 weeks.
- Bradycardia: Slows heart rate. If pulse drops below 50-55 bpm, dose reduction is necessary.
- Diabetes: Beta-blockers can mask the symptoms of hypoglycemia (like tremors and palpitations). Diabetics must be warned.
- Bronchospasm: Although cardioselective, use with caution in severe asthma or COPD.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
