BENZTHIAZIDE + TRIAMTERENE TABLETS

Description

Benzthiazide & Triamterene Tablets (25 mg / 50 mg)

Healthy Inc is a specialized global supplier and exporter of advanced cardiology, nephrology, and targeted diuretic therapeutics. We provide ultra-high-purity, kinetically balanced Benzthiazide & Triamterene Tablets, manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Thiazide & Potassium-Sparing Diuretic FDC” is a massive-volume strategic export to cardiology hospitals, hypertension clinics, and government health ministries, serving as the globally mandated intervention for Hypertension and Congestive Heart Failure (CHF) with edema.

Product Overview

This formulation operates as a dual-front fluid regulator. It is specifically engineered to maximize the excretion of excess water and sodium while neutralizing the mineral imbalances typically caused by traditional “water pills.”

• Mechanism 1 (The Sodium Flush – Benzthiazide): As a potent Thiazide diuretic, Benzthiazide inhibits the reabsorption of sodium and chloride in the Distal Convoluted Tubule. This physically forces the body to shed excess fluid, reducing blood volume and lowering blood pressure.

• Mechanism 2 (The Potassium Shield – Triamterene): Unlike Thiazides, Triamterene is a Potassium-Sparing agent. It blocks the epithelial sodium channels (ENaC) in the late distal tubule and collecting duct. This prevents the “exchange” process where the body normally dumps Potassium to save Sodium, thereby maintaining stable blood electrolyte levels.

• Mechanism 3 (Synergistic Diuresis): Because these two agents work on different segments of the Nephron, they provide a more comprehensive fluid clearance than either drug used alone, making it highly effective for refractory edema.

Product Composition & Strength

We supply this product as a Precision-Blended, High-Disintegration Tablet, packed in high-barrier Alu-PVC or Alu-Alu blister strips.

Technical & Logistics Specifications

• HS Code: 3004.90.69 (Medicaments containing other active substances – Diuretics)

• CAS Numbers: 91-33-8 (Benzthiazide) / 396-01-0 (Triamterene)

• Dosage Form: Uncoated or Film-Coated Tablet

• Packaging: Alu-PVC or Alu-Alu Blisters. Protects the formulation from light and environmental humidity across Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Content Uniformity Mastery: Our facility utilizes High-Shear Granulation to ensure the specific 1:2 ratio of Benzthiazide to Triamterene is maintained perfectly across every tablet in a million-unit batch.

• API Purity Protocols: We utilize advanced HPLC monitoring to ensure zero presence of related sulfonamide impurities, ensuring maximum safety for long-term hypertensive therapy.

Primary Indications

• Cardiology: Treatment of Hypertension (High Blood Pressure) alone or as adjunct therapy.

• Nephrology: Management of Edema associated with Congestive Heart Failure, Hepatic Cirrhosis, and Nephrotic Syndrome.

• Geriatrics: Preferred diuretic for elderly patients at high risk of electrolyte imbalance.

Dosage & Administration

• Standard Adult Dosing: Usually 1 to 2 tablets daily, taken after meals to enhance absorption and minimize GI upset.

• The “Morning Dose” Recommendation: Best taken in the morning to avoid nocturnal diuresis (frequent nighttime urination) which can disrupt patient sleep.

Safety Warning: Risk of Hyperkalemia (High Potassium). Strictly contraindicated in patients with severe renal impairment, anuria, or those already taking Potassium supplements. Monitor serum electrolytes regularly.

Global Export & Contract Manufacturing

Healthy Inc is a premier Cardiovascular Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for specialized Diuretic FDCs. Whether you are a Public Health Tender Buyer in Africa or a B2B Pharma Marketplace partner in Southeast Asia, we ensure secure, WHO-GMP compliant delivery.