Description
Acenocoumarol Tablets (1 mg / 2 mg / 3 mg / 4 mg)
Healthy Inc is a specialized global supplier and exporter of advanced cardiology, hematology, and targeted cardiovascular therapeutics. We provide ultra-high-purity, kinetically optimized Acenocoumarol Tablets, manufactured in WHO–GMP certified, high-precision specialized oral solid dosage facilities. This “Coumarin-Derivative Anticoagulant” is a critical strategic export to cardiac hospitals, vascular surgery units, and government health ministries, serving as the globally mandated intervention for the prevention and treatment of thromboembolic diseases.
Product Overview
This formulation operates as a “Clot-Prevention Shield.” It interferes with the body’s ability to use Vitamin K, which is a key ingredient needed to create the “glue” that makes blood clot.
Mechanism 1 (Vitamin K Epoxide Reductase Inhibition): Acenocoumarol inhibits the enzyme Vitamin K Epoxide Reductase. This prevents the recycling of Vitamin K, physically stopping the liver from producing functional clotting factors (II, VII, IX, and X).
Mechanism 2 (Short Half-Life Advantage): Unlike Warfarin, Acenocoumarol has a shorter half-life (approx. 8–11 hours). This allows for Faster Stabilization of the INR and quicker recovery of clotting function if the medication needs to be stopped for surgery or due to bleeding.
Mechanism 3 (Thromboembolic Prophylaxis): By maintaining the blood in a slightly “thinner” state, it prevents the formation of dangerous clots in the heart or deep veins that could lead to strokes or pulmonary embolisms.
Product Composition & Strength
We supply this product in multiple strengths to allow for the precise, micro-gram level titration required for safe anticoagulation.
| Active Ingredient | Strength | Primary Clinical Function |
| Acenocoumarol USP/BP/Ph.Eur. | 1 mg / 2 mg | The Titration Unit: Used for fine-tuning the maintenance dose to keep the INR within the target range (usually 2.0–3.0). |
| Acenocoumarol USP/BP/Ph.Eur. | 3 mg / 4 mg | The Loading/Anchor Dose: Used for initial therapy or for patients requiring higher systemic anticoagulation. |
| Excipients | Proprietary Matrix | Bio-Stable System: Engineered to ensure consistent oral absorption and predictable pharmacokinetics. |
Technical & Logistics Specifications
HS Code: 3004.90.69 (Medicaments acting on the blood – Anticoagulants)
CAS Number: 152-72-7 (Acenocoumarol)
Dosage Form: Uncoated or Film-Coated Tablet (Scored for half-dosing)
Packaging: Alu-Alu Blisters. Protects the sensitive API from light and moisture; our moisture-lock packaging ensures 24-month stability in Zone IVb tropical climates.
Manufacturing Authority & Compliance
Micro-Dose Content Uniformity: Since small changes in dose significantly impact bleeding risk, our facility utilizes Validated High-Precision Blending to ensure every tablet contains the exact stated micro-gram dose.
API Purity Excellence: Our manufacturing process focuses on absolute chemical stability, ensuring the Coumarin derivative remains potent and free from impurities, providing the predictable INR response required for chronic patients.
Primary Indications
Cardiology: Prevention of systemic embolism in patients with Atrial Fibrillation (AF) or prosthetic heart valves.
Vascular Medicine: Treatment and prophylaxis of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE).
Post-Operative Care: Prevention of venous thromboembolism following major orthopedic or general surgery.
Dosage & Administration
Standard Adult Dosing: Highly individualized based on INR (International Normalized Ratio) blood tests. Typically starts at 2 mg to 4 mg daily, followed by maintenance doses adjusted to keep INR in the target range.
Administration: Must be taken at the same time every day, preferably in the evening.
Safety Warning: Severe Bleeding Risk. Monitor for any unusual bruising, nosebleeds, or blood in urine/stool. MANDATORY: Regular INR monitoring is required. Pregnancy Caution: Strictly contraindicated in pregnancy due to fetal warfarin syndrome (teratogenicity). Many drugs and foods (rich in Vitamin K, like spinach) interact with this medication.
Global Export & Contract Manufacturing
Healthy Inc is a premier Cardiovascular Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-precision Anticoagulants. Whether you are a Cardiac Specialist Center in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.
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